Adenomatous Polyposis-coli
Mesenchymal adenomatous polyposis coli plays critical and diverse roles in regulating lung development
... Adenomatous polyposis coli (Apc) was originally discov- ered as a tumor suppressor gene, and loss of function mu- tation of Apc results in colon cancer ...familial adenomatous polyposis ...
19
A novel pathogenic germline mutation in the adenomatous polyposis coli gene in a Chinese family with familial adenomatous coli
... Familial adenomatous polyposis (FAP) is an autosomal dominant disease manifesting as colorectal cancer in middle-aged ...the adenomatous polyposis coli (APC) gene contribute to both FAP ...
8
Adenomatous polyposis coli regulates radial axonal sorting and myelination in the PNS
... Adenomatous polyposis coli (APC) is a member of the β -catenin destruction complex that mediates the degradation of β -catenin and thereby is involved in the Wnt signaling pathway (Nathke, ...
11
Adenomatous Polyposis Coli (APC) Is Required for Normal Development of Skin and Thymus
... The tumor suppressor gene Apc (adenomatous polyposis coli) is a member of the Wnt signaling pathway that is involved in development and tumorigenesis. Heterozygous knockout mice for Apc have a tumor ...
14
miR 582 5P induces colorectal cancer cell proliferation by targeting adenomatous polyposis coli
... Background: microRNA (miRNAs) dysregulation is widely involved in cancer progression and contributed to sustained cell proliferation by directly targeting multiple targets. Therefore, better understand the underlying ...
7
Molecular analysis of germline and somatic mutation in adenomatous polyposis coli
... (adenomatous polyposis coli) which manifests itself at a much earlier age than non-inherited colorectal ...with adenomatous polyposis ...
301
Adenomatous polyposis coli regulates Drosophila intestinal stem cell proliferation
... Adenomatous polyposis coli (Apc) encodes an evolutionarily conserved protein, which was first identified by positional cloning as one of the genes commonly deleted in the hereditary colon cancer ...
10
Immunopurification of adenomatous polyposis coli (APC) proteins
... The adenomatous polyposis coli (APC) gene is mutated in the germline of individuals with familial adenomatous polyposis (FAP) and in more than 80% of sporadic colo- rectal cancers ...
8
Analysing the mutational status of adenomatous polyposis coli (APC) gene in breast cancer
... Breast tissue samples and matched peripheral blood sam- ples from 89 breast cancer patients who had undergone surgery at China Medical University Hospital (Taichung City, Taiwan) from [r] ...
6
Mutation analysis of the adenomatous polyposis coli gene
... The detection of both germline and somatic APC mutations in four of the FAP associated desmoids, and the detection o f two somatic mutations in a sporadic desmoid suggest[r] ...
313
Early Detection of Adenomatous Polyposis Coli in Gardner's Syndrome
... Since colonoscopy combined with mucosal biopsies is a more direct method of diagnosing early adenomatous hyperplasia or polyposis than is a barium enema, we consider this the preferred p[r] ...
8
A novel pathogenic large germline deletion in adenomatous polyposis coli gene in a Chinese family with familial adenomatous polyposis
... In this Chinese family, diagnosis of FAP has been done according to a review of clinical report, endoscopic and histo-pathological data. However, the presence of specific clinical symptoms (colorectal ...
9
The second international genomic medicine conference (2nd IGMC, 2013): brief report and outcome
... APC: Adenomatous Polyposis Coli; BMC: BioMed Central; CEGMR: Center of Excellence in Genomic Medicine Research; ChIP-Seq: Chromatin Immuno- precipitation Sequencing; CIPM: Centre of Innovation in ...
5
High-frequency deregulated expression of Wnt signaling pathway members in breast carcinomas
... Materials and methods: We immunohistochemically examined various components of Wnt signaling pathway including β -catenin, tumor suppressor proteins, adenomatous polyposis coli (APC)[r] ...
13
The effects of a high carbohydrate and high fat diet and dietary interventions in the molecular tumourigenesis of colorectal cancer
... List of Abbreviations ADAM10- a disintegrin and metalloprotease domain 10 ADAM17- a disintegrin and metalloprotease domain 17 APC- adenomatous polyposis coli BRAF- v-Raf murine sarcoma v[r] ...
67
Analysis of molecular aberrations of Wnt pathway gladiators in colorectal cancer in the Kashmiri population
... The development and progression of colorectal cancer (CRC) is a multi-step process, and the Wnt pathways with its two molecular gladiators adenomatous polyposis coli (APC) and b-catenin plays an ...
12
The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinoma
... APC: adenomatous polyposis coli; BPDE: Benzo[ α ]pyrene diol epoxide; CDK: cyclin-dependent kinase; CHFR: Checkpoint with FHA and ring finger; CRC: colorectal cancer; DACH1: Dachshund homologue 1; ...
9
Colorectal carcinoma in the course of inflammatory bowel diseases
... APC: Adenomatous polyposis coli; CAC: Colitis - associated colorectal cancer; CD: Crohn ’ s disease; CIN: Chromosomal instability; COX-2: Cyclooxygenase 2; CRC: Colorectal cancer; DCC: Deleted in ...
9
Familial Adenomatous Polyposis (FAP) and Other Polyposis Syndromes
... The first advance in the understanding of the molecular nature of FAP occurred after the discovery by Herrera et al. [27] of a mentally retarded male who presented with Gardner’s syndrome. Cytogenetic analysis revealed ...
12
Familial adenomatous polyposis of the colon
... Familial adenomatous polyposis (FAP) is a well-defined autosomal dominant predisposition to the development of polyposis in the colon and rectum at unusually early ...of polyposis have been ...
9