Adenosine deaminase
Clinical study of meningitis in children and role of adenosine deaminase in differentiating tubercular from non-tubercular meningitis
... Background: In diseases where cell mediated immunity plays an important role like in tuberculosis, CSF (Cerebrospinal fluid) adenosine deaminase (ADA) activity is increased. Hence, this testing is done ...
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ADENOSINE DEAMINASE: A TARGET ENZYME IN DIFFERENT PATHOLOGIES – A REVIEW
... tissue. Adenosine deaminase is one of the enzymes participating in inactivation of the adenosine derivatives both in the intra- and intercellular ...of adenosine deaminase is a very ...
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Paradoxical expression of adenosine deaminase in T cells cultured from a patient with adenosine deaminase deficiency and combine immunodeficiency
... with adenosine deaminase (ADA) deficiency expressed ADA activity in the normal range, inconsistent with her severe immunodeficiency, metabolic abnormalities, and with the absence of ADA activity in her B ...
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Adiponectin hormone, adenosine deaminase enzyme and insulin adiponectin hormone, adenosine deaminase enzyme and insulin hormone levels in type 2 diabetic iraqi patients
... mostly by adipocytes and is important regulator of lipid and glucose metabolism. It is established that adiponect in is an insulin-sensitizing hormone with anti-diabetic, anti- inflammatory and anti- atherogenic ...
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Comparative analysis of cerebrospinal fluid adenosine deaminase levels in infective meningitis of different aetiologies
... Acid-fast staining of CSF sediment is the most rapid method for detection of mycobacterium, but this method lacks sensitivity. The use of polymerase chain reaction (PCR) to detect mycobacterium tuberculosis specific DNA ...
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Testicular ischemia in deficiency of adenosine deaminase 2 (DADA2)
... of adenosine deaminase 2 (DADA2) is a re- cently described recessive genetic autoinflammatory dis- ease [1, 2], with variable clinical penetration and severity, even in families with individuals sharing the ...
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Utility of pleural fluid adenosine deaminase in diagnosing tubercular pleural effusion: a prospective observational study in a tertiary care hospital
... Pleural Fluid Analysis including levels of protein, sugar, Adenosine Deaminase (ADA), LDH with cytological and microbiological examination was done in all patients. Using Pleural fluid analysis reports, ...
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Radioimmunochemical quantitation of human adenosine deaminase
... absent adenosine deaminase activity in man is associated with an autosomal recesive form of severe conbined immunodeficiency ...active adenosine deaminase (CRM) in the hemolysate of homozygous ...
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Plasma deoxyadenosine, adenosine, and erythrocyte deoxyATP are elevated at birth in an adenosine deaminase deficient child
... of adenosine, deoxyadenosine, and dATP are similar to those we observed in another older adenosine deaminase-deficient patient and may explain the impaired immune function and lymphopenia seen at ...
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Pleural Fluid Adenosine Deaminase for Diagnosis of Tuberculous Pleural Effusion
... pleuritis: Adenosine Deaminase (ADA), Lysozyme, Interferon gamma, and Polymerase Chain Reaction ...of adenosine to inosine, is found in most ...
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Diagnostic value of pleural fluid interferon-gamma and adenosine deaminase in patients with pleural tuberculosis in Qatar
... Tuberculosis (TB) is the most common cause of pleural effusion in areas with a high incidence of TB. The sensitivity of both direct microscopy and pleural fluid cultures is relatively low, and the diagnosis is mainly ...
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Proteins, lactate dehydrogenase and adenosine deaminase levels in pleural fluid - useful markers for differentiating tuberculosis from lung cancer
... and adenosine deaminase (ADA) level in pleural fluid for the differential diagnosis between tuberculous pleural effusion (TPE) and malignant pleural effusion ...
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Adenosine deaminase deficiency with normal immune function An acidic enzyme mutation
... lymphocyte adenosine deaminase activity and normal immune ...(a) adenosine deaminase activity and immunoreactive protein are undetectable in erythrocytes, ...plasma adenosine and ...
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A role for adenosine deaminase in human monocyte maturation
... of adenosine deaminase (ADA) activity in some patients with severe combined immunodeficiency suggests a possible relationship between the activity of ADA and the aberration of the immune ...
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Adenosine deaminase deficiency: a review
... glycol-conjugated adenosine deaminase (PEG-ADA) is the one therapeutic option that is not definitive in terms of disease correction but allows systemic clearance or ‘detoxification’ of the toxic metabolic ...
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Development of gene therapy: potential in severe combined immunodeficiency due to adenosine deaminase deficiency
... Abstract: The history of stem cell gene therapy is strongly linked to the development of gene therapy for severe combined immunodeficiencies (SCID) and especially adenosine deaminase (ADA)-deficient SCID. ...
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IgG antibody response to polyethylene glycol modified adenosine deaminase in patients with adenosine deaminase deficiency
... Polyethylene glycol (PEG)-modified bovine adenosine deaminase (ADA) is used for replacement therapy of severe combined immunodeficiency disease due to inherited ADA deficiency. We monitored IgG anti-ADA ...
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CSF Adenosine Deaminase (ADA) activity in Patients with Meningitis
... So in suspected meningitis patients, specific treatment for tuberculous or non-tuberculous bacterial or viral etiology is usually begun on the basis of presumptive clinical diagnosis.. M[r] ...
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T lymphocyte ontogeny in adenosine deaminase deficient severe combined immune deficiency after treatment with polyethylene glycol modified adenosine deaminase
... The development of antigen-specific T lymphocyte responses in the PEG-ADA-treated patients is similar to that seen in patients after bone marrow transplantation or in normal ontogeny 22-[r] ...
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Adenosine deaminase messenger RNAs in lymphoblast cell lines derived from leukemic patients and patients with hereditary adenosine deaminase deficiency
... ADA messenger RNAs and their translation products have been characterized in seven human lymphoblast cell lines derived as follows: GM130, GM-131, and GM-2184 from normal adults; GM-3043[r] ...
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