adenovirus vector
Characterization of the Recombinant Adenovirus Vector AdYB-1: Implications for Oncolytic Vector Development
... Recombinant adenovirus vectors. The E1/E3-deleted adenovirus vector AdYB-1 expresses the human transcription factor YB-1 under CMV promoter control as described by Holm et ...deleted vector ...
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Repeat administration of an adenovirus vector encoding cystic fibrosis transmembrane conductance regulator to the nasal epithelium of patients with cystic fibrosis
... an adenovirus vector to airway epithelium of patients with ...repeated adenovirus administra- tion to humans is unknown, and we wished to minimize the risk to participants if an adverse event should ...
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Gene targeting with a replication-defective adenovirus vector.
... with adenovirus insertion at the end of the homology between the donor and the ...of adenovirus DNA is inserted between two copies of the neo region with precise correction (Table 3, footnote k; ...the ...
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Adenovirus Vector Designed for Expression of Toxic Proteins
... binant adenovirus vector systems expressing the transgene from gene cassettes regulated by inducible promoters ...on adenovirus replication, we became aware of an unexpected complexity of our adeno- ...
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Enhancement of Adenovirus Vector Entry into CD70-Positive B-Cell Lines by Using a Bispecific CD70-Adenovirus Fiber Antibody
... the adenovirus-BZLF1 (AdZ) (Fig. 6A) or adenovirus-BRLF1 (AdR) ...6B) vector in the presence or absence of bispecific CD70-fiber ...an adenovirus vector expressing the -galactosidase ...
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Evaluation of biodistribution and safety of adenovirus vector containing MDR1 in mice
... In previous study, the concentration of adenovirus receptor in the liver was high, so as the distribution of adenovirus vector[18]. Some studies on the homing behavior of hemopoietic stem cells ...
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Adenovirus vector-infected cells can escape adenovirus antigen-specific cytotoxic T-lymphocyte killing in vivo.
... Recombinant adenovirus (Ad) vectors have many advan- tages for human gene therapy, but immune responses may present a barrier to their ...the vector genome was wild ...in vector-infected cells ...
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CXCL12 retargeting of an adenovirus vector to cancer cells using a bispecific adapter
... Ad5 vector) to ~ 50% (using sCAR-CXCL12- retargeted Ad vector) at 100 ...Ad vector in the presence of adapter sug- gests cancer specificity for binding of sCAR-CXCL12 with CXCR4-positive cancer ...Ad ...
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Efficient Gene Transfer into Human CD34+ Cells by a Retargeted Adenovirus Vector
... Ad5GFP/F35 vector ef- ficiently transduced cells carrying stem cell-specific markers, the next logical step would be to perform colony assays with presorted GFP-positive and -negative ...
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Characterization of an oncolytic adenovirus vector constructed to target the cMet receptor
... Abstract: The cMet receptor is a homodimer with tyrosine kinase activity. Upon stimulation with its ligand, hepatocyte growth factor (HGF), the receptor mediates wide physiologic actions. The HGF-cMet signaling pathway ...
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Adenovirus vector expressing functional herpes simplex virus ICP0.
... Infection of HeLa cells or 293 cells a human embryo kidney cell line expressing adenovirus 5 Ela and -b functions with the MLP-0 recombinant results in the synthesis of more IE-0 mRNA an[r] ...
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Phylogenetic Analysis and Structural Predictions of Human Adenovirus Penton Proteins as a Basis for Tissue-Specific Adenovirus Vector Design
... other adenovirus species that can be used as new backbones for adenoviral ...human adenovirus (HAdV-B3) (47), and Ruszics et ...adenoviral vector based on a species D virus (HAdV-D19a) ...
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Immunogenicity of adenovirus vector vaccine targeting hepatitis B virus: non clinical safety assessment in non human primates
... cells, adenovirus (Ad) is a promising candi- date vector for gene delivery, and has been widely adopted for many gene therapy strategies developed to date ...
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The potential of a novel Adenovirus vector for vaccination
... is known to play a role in innate immunity (Appledorn et al., 2008) but its Ad PAMP has yet to be identified (Nayak & Herzog, 2010). Signalling through these receptors is known to drive Th1 immunity by the induction ...
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Persistence of recombinant adenovirus in vivo is not dependent on vector DNA replication.
... affect vector production or transgene expression but did prevent cleavage by ...methylated vector in C57BL/6 mice, adenovirus vector DNA was not cleaved by XhoI and therefore did not ...
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Biology of E1-Deleted Adenovirus Vectors in Nonhuman Primate Muscle
... An objective of this study was to test the hypothesis that transduction of skeletal muscle following intramuscular admin- istration of an adenovirus vector would lead to prolonged transgene expression when ...
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Improvement of adenoviral vector-mediated gene transfer to airway epithelia by folate-modified anionic liposomes
... of adenovirus vector and anionic liposomes (AL-Ad5) by the calcium-induced phase change ...naked adenovirus vector, both AL-Ad5 and F-AL-Ad5 could significantly enhance the gene transduction ...
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Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy.
... enumerating adenovirus vector virions by bi- ological assays can be divided roughly into intrinsic properties of the virion and events which occur during the evaluation process itself as described in ...
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Key words
... Recombinant adenovirus vectors (rAdv) characterized by high transduction efficiency are employed to deliver genes to a variety of ...recombinant adenovirus vector not only resulted in a relatively ...
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Inhibitory effects of adenovirus mediated tandem expression of RhoA and RhoC shRNAs in HCT116 cells
... constructed adenovirus vector carrying RhoA and RhoC shRNAs in tandem expression and investigated the inhibitory effects of recombinant adenovirus on the cell proliferation and invasion of colorectal ...
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