adenylyl cyclase
Decreased Gs alpha mRNA levels accompany the fall in Gs and adenylyl cyclase activities in compensated left ventricular hypertrophy In heart failure, only the impairment in adenylyl cyclase activation progresses
... hypertrophy (LVH) and heart failure (HF) animals. Simultaneously, we measured the mRNA level encoding for the Gs alpha subunit. These studies indicate that Gs activity and Gs alpha mRNA are decreased by approximately 30% ...
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Digoxin reduces beta adrenergic contractile response in rabbit hearts Ca(2+) dependent inhibition of adenylyl cyclase activity via Na+/Ca2+ exchange
... neuronal adenylyl cyclase via Ca2+/calmodulin, mobilized Ca2+ directly inhibits adenylyl cyclase in other ...stimulated adenylyl cyclase ...
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Stimulation of electro-olfactogram responses in the main olfactory epithelia by airflow depends on the type 3 adenylyl cyclase
... Cilia of olfactory sensory neurons are the primary sensory organelles for olfaction. The detection of odorants by the main olfactory epithelium (MOE) depends on coupling of odorant receptors to the type 3 adenylyl ...
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The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein
... of adenylyl cyclase; the hormone, and G protein-regulated transmembrane adenylyl cyclases (tmACs) and the bicarbonate, ATP, and calcium- regulated ...
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Overexpression of the type 1 adenylyl cyclase in the forebrain leads to deficits of behavioral inhibition
... The mechanism for the hyperactivity/impulsivity of AC1⫹ mice is not clear. One plausible explanation would be that in- creasing AC1 activity leads to enhanced cAMP signaling and increased synaptic activity. At the ...
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Altered adenylyl cyclase activities and G protein abnormalities in portal hypertensive rabbits
... in adenylyl cyclase/cAMP system in prehepatic portal hypertensive rabbits and correlated these changes to the activity of a ...G-protein-stimulated adenylyl cyclase activities were lower in ...
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Disruption of type 3 adenylyl cyclase expression in the hypothalamus leads to obesity
... to adenylyl cyclase ...stimulates adenylyl cyclase activity in MC4-R-expressing neurons in the ventromedial hypothalamus ...major adenylyl cyclases expressed in the hypothalamus and AC3 ...
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Glucagon stimulable adenylyl cyclase in rat liver Effects of chronic uremia and intermittent glucagon administration
... glucagon-stimulable adenylyl cyclase in rat liver were assessed by determinations of adenylyl cyclase activities, specific iodoglucagon binding, and the activity of the stimulatory regulatory ...
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Role of adenylyl cyclase 6 in the development of lithium-induced nephrogenic diabetes insipidus
... Psychiatric patients treated with lithium (Li + ) may develop nephrogenic diabetes insipidus (NDI). Although the etiology of Li + -induced NDI (Li-NDI) is poorly understood, it occurs partially due to reduced aquaporin-2 ...
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cAMP production by adenylyl cyclase G induces prespore differentiation in Dictyostelium slugs
... maturation. Adenylyl cyclase B (ACB) produces cAMP for maturation, but the cAMP source for prespore induction is ...that adenylyl cyclase G (ACG) protein is upregulated in prespore tissue ...
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Adenylyl cyclase-cyclicAMP signaling in mood disorders: Role of the crucial phosphorylating enzyme protein kinase A
... Abstract: Mood disorders are among the most prevalent and recurrent forms of psychiatric illnesses. In the last decade, there has been increased understanding of the biological basis of mood disorders. In fact, novel ...
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Failure of hCG/LH receptors to stimulate the transmembrane effector adenylyl cyclase in human endometrium
... Studies to evaluate AC sensitivity to hCG were carried out under conditions allowing maximal enzyme activa- tion. Because the capacity of AC to respond to hormonal stimulation is dependent on guanine nucleotide [24,29], ...
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Calcium activated adenylyl cyclase AC8 but not AC1 is required for prolonged behavioral anxiety
... Results: In the present study, we wanted to examine possible molecular mechanisms for behavioral anxiety after repeated exposures. Performing a paradigm of five sessions of the elevated plus-maze (EPM), we show that the ...
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Measles virus modulates human T-cell somatostatin receptors and their coupling to adenylyl cyclase.
... increased adenylyl cyclase activity three- to fourfold from basal values (Table ...(striatum) adenylyl cyclase activity taken as the positive control (Table ...enylyl cyclase activity ...
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Adenylyl cyclase dependent axonal targeting in the olfactory system
... in adenylyl cyclase 3 (adenylate cyclase 3)-deficient ...the cyclase depletion leads to the prevention of neuropilin 1 (Nrp1) expression in olfactory sensory neuron axonal ...cascade, ...
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Modulation of adenylyl cyclase by GABAB receptors in vitro and in vivo
... of adenylyl cyclase activity in two different ...of adenylyl cyclase, th ey also found th a t flu o ro c itra te w as e q u a lly effective in th e p re se n c e a n d a b se n c e of p h o s ...
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5-25-2015 The type 3 adenylyl cyclase is required for the survival and maturation of newly generated granule cells in the olfactory bulb
... The type 3 adenylyl cyclase (AC3) is localized to olfactory cilia in the main olfactory epitheli- um (MOE) and primary cilia in the adult mouse brain. Although AC3 has been strongly impli- cated in odor ...
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Role of adenylyl cyclase S674 in central and forearm vasomotor control
... The purpose of the present study was to identify the role of AC S674 in cardiac and vasomotor control. First, compared with non-variant, individuals with AC S674 expressed decreased baseline cardiac contractility (SV and ...
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Glucagon stimulable adenylyl cyclase in rat liver The impact of streptozotocin induced diabetes mellitus
... of adenylyl cyclase as well as basal, sodium fluoride, 5' guanylylimidodiphosphate [GMP-P(NH)P] and Mn-dependent activities were reduced 50%, glucagon receptor levels but not affinity were reduced 67%, and ...
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Regulation of hormone sensitive calcium influx by the adenylyl cyclase system in renal epithelial cells
... Expression of a mutant regulatory type I subunit for cAMP-dependent protein kinase with reduced affinity for cAMP and treatment with KT-5720, a specific cAMP-dependent protein kinase inh[r] ...
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