Adherens junction
<p>Comparative study of in vitro effects of different nanoparticles at non-cytotoxic concentration on the adherens junction of human vascular endothelial cells</p>
... HUVECs that cover the lumen of blood vessels have been considered as a general model for access the toxicity of NPs. 41 There are two prevailing paradigms on how NPs traverse across endothelial barriers. 42 One is a ...
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Phosphorylation potential of Drosophila E Cadherin intracellular domain is essential for development and adherens junction biosynthetic dynamics regulation
... Phosphorylation of a highly conserved serine cluster in the intracellular domain of E-Cadherin is essential for binding to β - Catenin in vitro. In cultured cells, phosphorylation of specific serine residues within the ...
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The vav oncogene antagonises EGFR signalling and regulates adherens junction dynamics during Drosophila eye development
... cell-cell junction dynamics and adhesion is fundamental for epithelial morphogenesis and reshaping, and various members of the Rho GTPases and their GEF regulators have been implicated in these processes during ...
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Atonal and EGFR signalling orchestrate rok and Drak dependent adherens junction remodelling during ommatidia morphogenesis
... Morphogenesis of epithelial tissues relies on the interplay between cell division, differentiation and regulated changes in cell shape, intercalation and sorting. These processes are often studied individually in ...
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Quantitative cell polarity imaging defines leader to follower transitions during collective migration and the key role of microtubule dependent adherens junction formation
... The directed migration of cell collectives drives the formation of complex organ systems. A characteristic feature of many migrating collectives is a ‘tissue-scale’ polarity, whereby ‘leader’ cells at the edge of the ...
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Pathogenic Hantaviruses Andes Virus and Hantaan Virus Induce Adherens Junction Disassembly by Directing Vascular Endothelial Cadherin Internalization in Human Endothelial Cells
... control adherens junction disassembly (10, 17, 34, 57, ...cell-specific adherens junction protein and the primary determinant of paracellular perme- ability within the vascular endothelium ...
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WIF1 prevents Wnt5A mediated LIMK/CFL phosphorylation and adherens junction disruption in human vascular endothelial cells
... Findings: Here, we investigate the antagonistic effect of the Ryk specific secreted Wnt antagonist Wnt inhibitory factor (WIF)-1 on Wnt5A-mediated activation/inactivation of LIMK/CFL, and adherens junction ...
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Identification of deubiquitylases involved in the regulation of adherens junction components
... Wnt signalling pathway Cancer associated mutations found in the N-‐terminal regulatory region of β-‐catenin The structure of the eukaryotic 26S proteasome [r] ...
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Rho-Associated Coiled-Coil Kinase (ROCK) in Molecular Regulation of Angiogenesis
... AJ: adherens junction; AMPK: adenosine monophosphate-activated protein kinase; Ang II: angiotensin II; AT1R: Ang II type 1 receptor; AT2R: Ang II type 2 receptor; CCM2: cerebral cavernous malformations 2; ...
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Diverse cell junctions with unique molecular composition in tissues of a sponge (Porifera)
... encoding adherens junc- tion and focal adhesion proteins in diverse sponges ...to adherens junction and focal adhe- sions in bilaterians) was detected at cell–cell and cell– ECM adhesions, and was ...
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Characterisation of the signal transduction pathways mediating the hepatocyte growth factor/scatter response in MDCK cells
... via adherens, tight junctions and desmosomes (Ben-Ze'ev, ...of adherens junctions, but tight junctions and desmosomes are retained (Warren and Nelson, ...f adherens junctions correlates with ...
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Blood–brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders
... AJ: Adherens junction; ASD: Autism spectrum disorders; BBB: Blood – brain barrier; BCS: Blood – cerebrospinal; CBL: Cerebellum; CLDN: Claudin; CNS: Central nervous system; GBA: Gut – brain axis study; GI: ...
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HIF2α signaling inhibits adherens junctional disruption in acute lung injury
... With regard to regulation of endothelial barrier function, VE- cadherin, a transmembrane glycoprotein forming homophilic cis and trans dimers essential for the development of inter-EC adhe- rens junctions (AJs), may be ...
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Limited forward trafficking of connexin 43 reduces cell cell coupling in stressed human and mouse myocardium
... ments indicate that delivery to gap junction plaques can occur within minutes (19, 24). With full cycles of turnover occurring several times per day, forward trafficking of de novo channel is a major opportu- nity ...
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Traditional Chinese Medicine and regulatory roles on epithelial–mesenchymal transitions
... AJ: adherens junction; BMDCs: bone marrow‑derived cells; CTC : circulating tumor cells; CSF1: colony stimulating factor 1; COX2: cyclooxygenase2; EPCs: endothelial progenitor cells; EGF: epidermal growth ...
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Label-free mass spectrometry proteome quantification of human embryonic kidney cells following 24 hours of sialic acid overproduction
... of adherens junctions between neighboring cells has been shown to be dependent on the cellular density of growing epithelial cell populations ...in junction stability are thought to arise from al- terations ...
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Macroglobulin complement related encodes a protein required for septate junction organization and paracellular barrier function in Drosophila
... the adherens junction and are characterized ultrastructurally as a series of anastamosing ribbons, where the plasma membranes of adjacent cells are in direct opposition (Farquhar and Palade, ...the ...
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Modelling the structure of a ceRNA theoretical, bipartite microRNA–mRNA interaction network regulating intestinal epithelial cellular pathways using R programming
... We selected approximately 200 protein-coding genes of interest to use in downstream expression profiling on the Nanostring ® platform. Protein-coding genes with overlapping membership in canonical KEGG pathways of ...
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Alteration in the mRNA expression of genes associated with gastrointestinal permeability and ileal TNF-α secretion due to the exposure of silver nanoparticles in Sprague–Dawley rats
... cell junction genes were affected by 10 nm AgNPs. Tight junction (Cldn1, Cldn5, Cldn6, Cldn10 and Pecam1), focal adhesion (Cav1, Cav2, and Itgb2), adherens junction (Pvrl1, Notch1, and ...
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DE Cadherin regulates unconventional Myosin ID and Myosin IC in Drosophila left right asymmetry establishment
... the adherens junction components leads to a sinistral phenotype? In other words, does DE-Cadherin depletion also affect sinistral development or pathway, which is taking over in absence of MyoID? To tackle ...
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