Adipose tissue dysfunction in obesity
Hypertrophic Obesity and Subcutaneous Adipose Tissue Dysfunction
... Adipose tissue can be divided into two major types: white adipose tissue (WAT) and brown adipose tissue (BAT), both of which have different physiological roles ascribed to ...
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Hypoxia and adipose tissue function and dysfunction in obesity
... and Adipose Tissue Function and Dysfunction in ...of obesity has led to a major interest in the biology of white adipose ...The tissue is a major endocrine and signaling organ, ...
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Hypertrophic Obesity and Subcutaneous Adipose Tissue Dysfunction
... Adipose tissue can be divided into two major types: white adipose tissue (WAT) and brown adipose tissue (BAT), both of which have different physiological roles ascribed to ...
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Obesity, estrogens and adipose tissue dysfunction : implications for pulmonary arterial hypertension
... of adipose tissue to expand and store ...for adipose expansion is determined by both genetic and environmental factors and once the adipose tissue expansion limit is reached, ...
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Adipose tissue metabolism in acquired obesity
... the adipose tissue of the obese twins of group 2, with increased amounts of liver fat and with metabolic ...of adipose tissue seem to be linked to the metabolic problems of obesity, the ...
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Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p'-DDE
... metabolic dysfunction, we further evaluated the contribution of the mesenteric vAT impairment, considered determinant in the causal pathway of the MetS and dysmetabolic obesity 3, 4 ...to ...
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Adipose tissue inflammation is a hallmark of obesity and
... for adipose tissue ...in adipose tissue inflammatory responses and decreased adipose tissue insulin signaling accompanied by inappropri- ate adipokine expression, which are ...
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Glucotoxicity, Protein Glycation and Adipose Tissue Dysfunction
... in adipose tissue DPP4 will have a strong impact: it stimulates lipid accumulation and PPARγ expression and it may be involved in remodeling and inflammation of adipose ...between obesity and ...
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Annexins in Adipose Tissue: Novel Players in Obesity
... Abstract: Obesity and the associated comorbidities are a growing health threat ...worldwide. Adipose tissue dysfunction, impaired adipokine activity, and inflammation are central to metabolic ...
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Hypoxia-inducible factor 3A gene expression and methylation in adipose tissue is related to adipose tissue dysfunction
... subcutaneous adipose tissue, paired two-tailed t-tests were ...to obesity, fat distribution and glucose and insulin ...and obesity (lean with BMI < 25 kg/m 2 ...
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Drugs Involved in Dyslipidemia and Obesity Treatment: Focus on Adipose Tissue
... visceral obesity, atherogenic dyslipidemia, arterial hypertension, and insulin ...disease. Obesity and dyslipidemia are main features of metabolic syndrome, and both can present with adipose ...
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The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis
... age-related dysfunction of adipocyte progenitors and metabolism, as elegantly demon- strated in mice expressing a p16INK4a promoter–driven inducible caspase-8 (INK4-ATTAC mice) ...
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The impact of human adipose tissue on metabolic dysfunction in obesity and type 2 diabetes mellitus
... from adipose tissue which may also support to lower CAD and T2DM ...human adipose from subjects in different metabolic states, with and without an LpPLA2 inhibitor may allow the assessment of how ...
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NPC1 in human white adipose tissue and obesity
... Background Obesity is characterized by an excess of white adipose tis- sue (WAT) and marked adipocyte dysfunction that in- crease the risk for insulin resistance, type 2 diabetes mellitus and ...
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Contribution of adipogenesis to healthy adipose tissue expansion in obesity
... pathologic obesity a form of relative lipodystrophy? Studies of mouse and human adipose tissue provide strong evidence that the inability to expand subcutaneous WAT depots (versus vis- ceral WAT ...
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Adipose Tissue, Inflammation (Meta-inflammation) and Obesity Management
... with obesity exhibit an impaired expandability of SAT which may initiate a sequence of pathogenic factors causing impaired AT ...and obesity associated, MC4R: Melanocortin 4 receptor, DGAT2: Diacylglycerol ...
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The Interaction of Obesity and Age and their effect on Adipose Tissue Metabolism in the Mouse
... of obesity caused by leptin deficiency, FA biosynthesis, and mitochondrial biogenesis are activated, but then impaired in the progression of ...mitochondrial dysfunction and increased ROS ...in ...
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Deciphering the cellular interplays underlying obesity induced adipose tissue fibrosis
... https://doi.org/10.1172/JCI129192. Obesity originates from an imbalance between caloric intake and energy expenditure that promotes adipose tissue expansion, which is necessary to buffer nutrient ...
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Adipose tissue remodeling and obesity
... energy-storing tissue, adipose has several unique properties that cannot be seen in any other organ, including an almost unlimited capacity to expand in a non-transformed ...between adipose expansion ...
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Obesity induced inflammatory changes in adipose tissue
... to adipose tissue inflammation in mice with null mutations in these genes might pro- vide insights into the aspects of the inflammatory response that are rele- vant to insulin ...in obesity and ...
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