adipose triglyceride lipase
Original Article The expressions of pigment epithelium-derived factor and adipose triglyceride lipase in human kidney and correlation with renal lipid accumulation
... Adipose triglyceride lipase (ATGL, also called patatin-like phospholipase domain-containing protein 2) is the first identified receptor for PEDF [10], which has been demonstrated to catalyze the ...
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Inhibition of adipose triglyceride lipase (ATGL) by the putative tumor suppressor G0S2 or a small molecule inhibitor attenuates the growth of cancer cells
... binds adipose triglyceride lipase ...inhibits triglyceride catabolism and results in lower cell ...increased triglyceride levels, attenuated cell growth and promoted ...
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Loss of adipose triglyceride lipase is associated with human cancer and induces mouse pulmonary neoplasia
... Although adipose tissue is the most efficient organ to store fat, essentially all other cell types can also deposit FA as ...are adipose triglyceride lipase (ATGL), hormone-sensitive ...
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Adipose triglyceride lipase decrement affects skeletal muscle homeostasis during aging through FAs-PPARα-PGC-1α antioxidant response
... the adipose triglyceride lipase (ATGL) catalyzes the first step of the TAGs lipolysis cascade, ...in adipose tissue and present, to a lesser extent, in testis, cardiac and skeletal muscle ...
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The role of adipose triglyceride lipase in lipid and glucose homeostasis: lessons from transgenic mice
... be adipose-specific, since only minute protein and mRNA expression was detected in other tissues such as skeletal muscle, cardiac muscle, kidney and testis of male mice ...maintained adipose TG levels ...
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Berberine increases adipose triglyceride lipase in 3T3-L1 adipocytes through the AMPK pathway
... adipocytes and plays a crucial role in adipogenesis. HSL and ATGL are rate-limiting enzymes that regulate the lipolysis of TG in adipocytes [3]. They catalyze the hydrolysis of TG and effect different catabolism courses ...
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Triglyceride deposit cardiomyovasculopathy: a rare cardiovascular disorder
... Triglyceride deposit cardiomyovasculopathy (TGCV) is a phenotype primarily reported in patients carrying genetic mutations in PNPLA2 encoding adipose triglyceride lipase (ATGL) which releases ...
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The effects of pigment epithelium-derived factor on atherosclerosis: putative mechanisms of the process
... ATGL: Adipose triglyceride lipase; ATP: Adenosine triphosphate; BNP: Brain natriuretic peptide; CAD: Coronary artery disease; CVD: Cardiovascular disease; EC: Endothelial cell; ECM: Extracellular ...
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Diet change and exercise enhance protein expression of CREB, CRTC 2 and lipolitic enzymes in adipocytes of obese mice
... Triacylglycerol (TAG) is hydrolyzed through the activ- ities of a trio of enzymes: adipose triglyceride lipase (ATGL), hormone sensitive lipase (HSL) and monoacyl- glycerol lipase (MGL) ...
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Exercise training improves intramuscular triglyceride lipolysis sensitivity in high-fat diet induced obese mice
... binds adipose triglyceride lipase (ATGL), which is the rate-limiting enzyme in TG hy- drolysis, and comparative gene identification-58 (CGI- 58, also known as ABHD5), a powerful activator of ATGL; ...
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Dietary supplement of Smilax china L. ethanol extract alleviates the lipid accumulation by activating AMPK pathways in high-fat diet fed mice
... AMPK and sterol regulatory element binding proteins (SREBPs) are known to participate in adipogenesis. AMPK is a serine/threonine protein kinase that func- tions as a metabolic master switch [11]. It is expressed in a ...
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Maternal sodium butyrate supplement elevates the lipolysis in adipose tissue and leads to lipid accumulation in offspring liver of weaning-age rats
... ATGL, adipose triglyceride lipase; CD36, fatty acid transfer proteins; CEBP β , CCAAT-enhancer binding proteins; CON, control; CPT-1A, Carnitine palmitoyltransferase 1A; CYP27A1, sterol ...
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Selective Measurement of Two Lipase Activities in Postheparin Plasma from Normal Subjects and Patients with Hyperlipoproteinemia
... protamine-inactivated lipase activity was markedly reduced, whereas protamine-resistant lipase was below normal in only ...both lipase activities were not reduced in 32 other patients with ...
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Abnormalities in very low, low and high density lipoproteins in hypertriglyceridemia Reversal toward normal with bezafibrate treatment
... ultracentrifugation, were determined. HTG-LDL appears as multiple fractions whereas HTG- HDL is seen predominantly as HDL3. HTG-VLDL is relatively poor in apoproteins and triglycerides but enriched in free and esterified ...
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Antibody mediated targeting of the FGFR1c isoform increases glucose uptake in white and brown adipose tissue in male mice
... white adipose tissue (WAT), brown adipose tissue (BAT), the brain, and liver but reduced it in the quadriceps ...decreased triglyceride (TG) content and increased adipose TG lipase ...
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Genetic basis of lipoprotein disorders
... These include the apolipoproteins, A-I, A-II, A-IV, B, CI, CII, CIII, D, E, and apoa, the lipoprotein processing proteins, lipoprotein lipase LPL,1 hepatic triglyceride lipase HTGL, leci[r] ...
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Triglyceride Storage Disease: A Defect in Activation of Lipolysis in Adipose Tissue
... The basal release of glycerol (Fig. 3, center) and fatty acids (Fig. 3, bottom) from hand and foot of proband is in the same range as release from adult adipose tissue. However, no stimu[r] ...
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JLR-2013-Yao-1058-65.pdf
... of triglyceride-rich lipoprotein clearance, lipo- protein lipase (LPL), in adipose tissue ( 24 ...inhibitor, adipose angiopoietin-like protein 4 (Angptl4) ( 24 ...on triglyceride (TG) ...
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The long term stability of triglyceride molecules in adipose tissue
... Rats weighing about 100 g were fed for 6 weeks a diet containing coconut oil as the sole source of fat.- This was done to determine whether the glyceride pattern of dietary fat would be [r] ...
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Regulation of lipoprotein lipase in primary cultures of isolated human adipocytes
... To study the regulation of adipose tissue lipoprotein lipase (LPL) in human adipocytes, omental adipose tissue was obtained from healthy subjects and digested in collagenase. The isolated adipocytes ...
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