ADP ribosylation
Analysis of ADP-Ribosylation and Protein Sample Preparation by Capillary Electrophoresis
... Compared to protein poly-ADP-ribosylation, mono-ADP-ribosylation remains little explored and recent studies indicate that they have potentially very important roles to play in a number of ...
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ADP Ribosylation Factor 1 Plays an Essential Role in the Replication of a Plant RNA Virus
... Eukaryotic positive-strand RNA viruses replicate using the membrane-bound replicase complexes, which contain multiple viral and host components. Virus infection induces the remodeling of intracellular membranes. ...
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Role of a TRIM72 ADP-ribosylation cycle in myocardial injury and membrane repair
... that ADP-ribosylated TRIM72 levels were higher in ARH1-KO than WT myocardium (Figure ...3D). ADP-ribosylation of TRIM72 was enhanced by I/R injury, but not by ischemia only, suggesting that cardiac ...
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Role for ADP Ribosylation Factor 1 in the Regulation of Hepatitis C Virus Replication
... We hypothesized that ADP-ribosylation factor 1 (Arf1) plays an important role in the biogenesis and maintenance of infectious hepatitis C virus (HCV). Huh7.5 cells, in which HCV replicates and produces ...
11
Hormonal Stimulation of Eucaryotic Cell ADP ribosylation: EFFECT OF THYROTROPIN ON THYROID CELLS
... The effect of thyrotropin (TSH) on the ADP-ribosylation of endogenous thyroid cell acceptor proteins was examined. Cells were “permeabilized” at 4°C in hypotonic medium and then exposed to [ 32 P]- or [ 3 ...
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ARTD10 substrate identification on protein microarrays: regulation of GSK3β by mono-ADP-ribosylation
... mono- ADP-ribosylation of GSK3β in cells due to lack of suitable reagents, but together these findings support the hypoth- esis that mono-ADP-ribosylation by ARTD10 inhibits GSK3β activity not ...
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Cloning and characterization of ADP-ribosylation factor 1b from the olive flounder Paralichthys olivaceus
... The ADP-ribosylation factors (ARFs) can be classified into three groups based on the peptide sequence, protein molecular weight, gene structure, and phylogenetic ...
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Crosstalk between SET7/9-dependent methylation and ARTD1-mediated ADP-ribosylation of histone H1.4
... Covalent histone modifications can alter chromatin structure and thereby define transcriptionally active or inactive chromatin states [29]. Compared with core his- tones, little is known about the modifications and the ...
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ADP Ribosylation Factor 1 Activity Is Required To Recruit AP-1 to the Major Histocompatibility Complex Class I (MHC-I) Cytoplasmic Tail and Disrupt MHC-I Trafficking in HIV-1-Infected Primary T Cells
... HIV-1-infected cells are partially resistant to anti-HIV cytotoxic T lymphocytes (CTLs) due to the effects of the HIV Nef protein on antigen presentation by major histocompatibility complex class I (MHC-I), and evidence ...
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GB virus type C E2 protein inhibits human immunodeficiency virus type 1 Gag assembly by downregulating human ADP- ribosylation factor 1
... GB virus type C (GBV-C) glycoprotein E2 protein disrupts HIV-1 assembly and release by inhibiting Gag plasma membrane targeting, however the mechanism by which the GBV-C E2 inhibits Gag trafficking remains unclear. In ...
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ALTERATIONS OF ADP-RIBOSYLATION AND DNA-BREAKS IN AGING BRAIN CELLS
... poly ADP-ribosylation and DNA breaks with ...poly ADP-ribosylation was observed in the whole brain cell suspension of aged rats, whereas the increase was markedly pronounced (460%) when the ...
5
ADP Ribosylation of NLRP3 by Mycoplasma pneumoniae CARDS Toxin Regulates Inflammasome Activity
... bacterial ADP-ribosylating and vacuolating toxin produced by Mycoplasma pneumoniae and des- ignated community-acquired respiratory distress syndrome (CARDS) toxin (16) interacts with the NLRP3 inflammasome complex ...
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Viral Macro Domains Reverse Protein ADP-Ribosylation
... Here, we show that the HEV macro domain can reverse auto- ADP-ribosylation of several ARTs in vitro. Abrogation of this ac- tivity through mutations in the macro domain dramatically de- creases replication ...
9
Role of PARP and protein poly-ADP-ribosylation process in regulation of cell functions
... більше того, під час естрогеніндукованої транскрипції гену супресії пухлин TFF1 (Trefoil factor 1), PARP-1 не тільки сприяє ви- даленню Н1, але й підвищує вміст HMGB1 (High-mobility group box 1), архітектурного протеїну ...
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Identification of ADP-ribosylation factor as a requirement for g-protein-mediated phospholipase D activation and secretion in HL60 cells
... The residual and variable GTPyS response which is observed in cytosol-depleted cells for both the PLD and secretory responses, is postulated to be as a result of the presen[r] ...
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Polyoma virus minichromosomes: poly ADP-ribosylation of associated chromatin proteins.
... Specific activities of polyADP-rib polymerase of HeLa cell nucleosomes and polyoma RI and mature chromatin Incorporation into histone fractionb Poly ADP-ribosylationa Source of chromatin[r] ...
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ADP-ribosylation factor 1 expression regulates epithelial- mesenchymal transition and predicts poor clinical outcome in triple-negative breast cancer
... ARF1 expression controls the formation of primary tumors and metastases in vivo To investigate the role of ARF1 in tumor formation and metastasis, we generated a human TNBC cell line exp[r] ...
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Time course of nitric oxide synthases, nitrosative stress, and poly(ADP ribosylation) in an ovine sepsis model
... Methods: Twenty-four chronically instrumented sheep were subjected to inhalation of 48 breaths of cotton smoke and instillation of live Pseudomonas aeruginosa into both lungs and were euthanized at 4, 8, 12, 18, and 24 ...
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Poliovirus Proteins Induce Membrane Association of GTPase ADP-Ribosylation Factor
... Transport vesicles may show some morphological similarity to those induced during poliovirus infection; therefore, one of the roles of ARF recruitment by poliovirus proteins may be to st[r] ...
10
Trafficking regulation of proteins in Alzheimer’s disease
... APP: Amyloid beta (A4) precursor protein; ARF6: ADP ribosylation factor 6; BACE1: Beta-site APP-cleaving enzyme 1; CTF: Carboxyl-terminal fragment; DS: Down syndrome; ER: Endoplasmic ret[r] ...
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