ADP-Ribosylation factor 6
Extracellular vesicles: mediators and biomarkers of pathology along CNS barriers
... ARF6: ADP-ribosylation factor 6; ART : antiretroviral therapy; BBB: blood–brain barrier; BCSFB: blood– cerebral-spinal-fluid barrier; BLMB: blood–leptomeningeal barrier; BMEC: brain ...
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Trafficking regulation of proteins in Alzheimer’s disease
... APP: Amyloid beta (A4) precursor protein; ARF6: ADP ribosylation factor 6; BACE1: Beta-site APP-cleaving enzyme 1; CTF: Carboxyl-terminal fragment; DS: Down syndrome; ER: Endoplasmic ret[r] ...
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Long non-coding RNAs: implications in targeted diagnoses, prognosis, and improved therapeutic strategies in human non- and triple-negative breast cancer
... ARF6: ADP-ribosylation factor 6; BC: Breast cancer; BCAR4: Breast cancer antiestrogen resistance 4; BLK: B lymphocyte kinase; BRCA1/2: Breast cancer 1/2; BRK: Breast tumor kinase; CCAT2: Colon ...
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ADP Ribosylation Factor 1 Activity Is Required To Recruit AP-1 to the Major Histocompatibility Complex Class I (MHC-I) Cytoplasmic Tail and Disrupt MHC-I Trafficking in HIV-1-Infected Primary T Cells
... HIV-1-infected cells are partially resistant to anti-HIV cytotoxic T lymphocytes (CTLs) due to the effects of the HIV Nef protein on antigen presentation by major histocompatibility complex class I (MHC-I), and evidence ...
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ADP-ribosylation factor 1 expression regulates epithelial- mesenchymal transition and predicts poor clinical outcome in triple-negative breast cancer
... (BD Bioscience) plus PBS and injected into the fourth mammary fat pads (MFP) of both flank of the anesthetized mice, using a 27mm gauge needle [46]. All animals were numbered and kept separately in a ...
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ADP Ribosylation Factor 1 Plays an Essential Role in the Replication of a Plant RNA Virus
... In this study, we found that p27 interacts with Arf1 and relocalizes this protein to the aggregate structures of ER membranes, where they colocalize (Fig. 1 and 2), suggesting that p27 recruits Arf1 to the viral ...
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Role for ADP Ribosylation Factor 1 in the Regulation of Hepatitis C Virus Replication
... Interesting in this context are observations suggesting that HCV negatively regulates the synthesis and secretion of VLDLs, components shown to be required for the morpho- genesis and secretion of HCV (for a recent ...
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Poliovirus Proteins Induce Membrane Association of GTPase ADP-Ribosylation Factor
... cation. We fractionated translation reaction mixtures by cen- trifugation and analyzed the pellets, containing membranes with associated proteins, and 1/10 of the supernatants by im- munoblotting with an anti-ARF ...
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Cloning and characterization of ADP-ribosylation factor 1b from the olive flounder Paralichthys olivaceus
... To determine the evolutionary relationship of PoARF1b with other ARFs, phylogenetic tree was performed using the Ensembl sequence data using the Neighbor-Joining Method by MEGA (version 6) with bootstrapping 2000 ...
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GB virus type C E2 protein inhibits human immunodeficiency virus type 1 Gag assembly by downregulating human ADP- ribosylation factor 1
... transfected with either VR1012 or IgG-E2 expression constructs into 293T cells. Twenty-four hours post- transfection, the cells were treated with either DMSO or the 26S proteasome inhibitor MG132 (also referred to as ...
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Insights into the genetics of blood pressure in black South African individuals: the Birth to Twenty cohort
... : ADP ribosylation factor like GTPase 6 interacting protein 6; AWI-Gen: African Wits-INDEPTH Partnership for the GENomic study of body composition and cardio- metabolic risk; BMI: Body ...
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Role of PARP and protein poly-ADP-ribosylation process in regulation of cell functions
... полімери ADP-рибози, що утво- рюються в полі(ADP-рибозо)глікогідролазній реакції здатні нековалентно взаємодіяти зі специфічними (ADP-рибозо)-зв’язувальними мотивами акцепторних протеїнів, що ...
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ARTD10 substrate identification on protein microarrays: regulation of GSK3β by mono-ADP-ribosylation
... mono- ADP-ribosylation of GSK3β in cells due to lack of suitable reagents, but together these findings support the hypoth- esis that mono-ADP-ribosylation by ARTD10 inhibits GSK3β activity not ...
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Analysis of ADP-Ribosylation and Protein Sample Preparation by Capillary Electrophoresis
... ARTDs 6–8, 10–12, and 14–16, which are confirmed or putative mARTs; and (3) ARTDs 9 and 13, which lack key NAD + -binding residues and the conserved catalytic glutamate residue, are thought to be ...
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Hormonal Stimulation of Eucaryotic Cell ADP ribosylation: EFFECT OF THYROTROPIN ON THYROID CELLS
... deoxyribonuclease digestion of trichloroacetic acid precipitable thyroid cell radioactivity, revealed primarily 5¢-AMP, consistent with an effect of TSH on mono-ADP ribosylation. Nicotinamide and thymidine ...
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Role of a TRIM72 ADP-ribosylation cycle in myocardial injury and membrane repair
... TRIM72 oligomerization assays. ARH1-deficient and WT mouse hearts were lysed in DPBS and incu- bated for the indicated time at 37°C. The proteins (50 μg) were separated under nonreducing conditions by 4–12% Bis-Tris ...
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Crosstalk between SET7/9-dependent methylation and ARTD1-mediated ADP-ribosylation of histone H1.4
... specific ADP-ribose modifications and their effect on SET7/9 ...identified ADP-ribose acceptor sites in histones (for example, K37 of H3) it is not yet possible to chem- ically synthesize peptides with ...
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Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes
... PARP1 has been detected in the nuclei of a variety of tissue types including the brain, heart, kidney, and testis [121]. PARP2 has been detected in the liver, kidney, spleen, adre- nal gland, stomach, intestinal ...
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Time course of nitric oxide synthases, nitrosative stress, and poly(ADP ribosylation) in an ovine sepsis model
... Methods: Twenty-four chronically instrumented sheep were subjected to inhalation of 48 breaths of cotton smoke and instillation of live Pseudomonas aeruginosa into both lungs and were euthanized at 4, 8, 12, 18, and 24 ...
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Deficient guanine nucleotide regulatory unit activity in cultured fibroblast membranes from patients with pseudohypoparathyroidism type I A cause of impaired synthesis of 3',5' cyclic AMP by intact and broken cells
... P]ADP ribosylation of G-unit peptides, as well as the G-unit activity, determined by the ability of detergent extracts to reconstitute adenylate cyclase activity in G-unit-deficient S49 CYC - membranes, ...
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