ADP-ribosyltransferase
Prevalence and Characterization of a Binary Toxin (Actin Specific ADP Ribosyltransferase) from Clostridium difficile
... In addition to the two large clostridial cytotoxins (TcdA and TcdB), some strains of Clostridium difficile also produce an actin-specific ADP-ribosyltransferase, called binary toxin CDT. We used a PCR ...
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The ADP Ribosyltransferase Domain of the Effector Protein ExoS Inhibits Phagocytosis of Pseudomonas aeruginosa during Pneumonia
... the ADP-ribosyltransferase activity of ExoS, but not the GTPase- activating protein activity, was responsible for bacterial persistence and decreased host survival in this ...the ...
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A Group A Streptococcus ADP Ribosyltransferase Toxin Stimulates a Protective Interleukin 1β Dependent Macrophage Immune Response
... SpyA contributes to bacterial clearance through canonical caspase-1-dependent processing to promote IL-1  activation and by increasing IL-1 transcription. Concurrent with increased re- covery of the ⌬ spyA mutant ...
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Activation of Adenylate Cyclase by Heat Labile Escherichia Coli Enterotoxin: EVIDENCE FOR ADP RIBOSYLTRANSFERASE ACTIVITY SIMILAR TO THAT OF CHOLERAGEN
... chromatograms similar to the reaction products obtained after incubation of choleragen with these substrates and are consistent with the formation of ADP-ribose-l-arginine and ADP- ribose-l-arginine methyl ...
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Dynamic subcellular localization of the mono-ADP-ribosyltransferase ARTD10 and interaction with the ubiquitin receptor p62
... mono- ADP-ribosyltransferase that was identified as an interaction partner of the oncoprotein MYC ...[1]. ADP-ribosylation is a posttranslational modification that controls both intra- and ...
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Broad Spectrum Regulation of Nonreceptor Tyrosine Kinases by the Bacterial ADP Ribosyltransferase EspJ
... and ADP- ...EspJ-induced ADP- ribosylation regulates multiple nonreceptor tyrosine kinases in ...bacterial ADP-ribosyltransferase that targets mammalian ki- nases, controls immune responses ...
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Plasmodium falciparum Sir2: an Unusual Sirtuin with Dual Histone Deacetylase and ADP-Ribosyltransferase Activity
... PfSir2 has ADP-ribosyltransferase in addition to HDAC activity. Most of the sirtuins characterized thus far have either deacetylase or ADP-ribosyltransferase activity but are not sig- ...
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Detection of antibodies inhibiting the ADP ribosyltransferase activity of pertussis toxin in human serum
... For the direct ADPribosyltransferase assay, diluted serum samples were added to pertussis toxin, the mixture was incubated, and the entire contents of the mixture were assayed.. A total [r] ...
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Assay of heat labile enterotoxins by their ADP ribosyltransferase activities
... A comparative study of enterotoxin gene probes and tests for toxin production to detect enterotoxigenic Escherichia coli.. Comparative study of synthetic oligonucleotide and cloned polyn[r] ...
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ADP Ribosylation of NLRP3 by Mycoplasma pneumoniae CARDS Toxin Regulates Inflammasome Activity
... bacterial ADP-ribosylating and vacuolating toxin produced by Mycoplasma pneumoniae and des- ignated community-acquired respiratory distress syndrome (CARDS) toxin (16) interacts with the NLRP3 inflammasome complex ...
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Activation of Escherichia coli heat labile enterotoxins by native and recombinant adenosine diphosphate ribosylation factors, 20 kD guanine nucleotide binding proteins
... The ADP-ribosyltransferase activity of CT is enhanced by 20-kD guanine nucleotide-binding proteins, known as ADP- ribosylation factors or ...its ADP ribosylation of Gs alpha, other proteins, ...
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The low molecular mass GTP binding protein Rho is affected by toxin A from Clostridium difficile
... ribosylation of Rho occurs in a time- and concentration-dependent manner and precedes the toxin A-induced destruction of the actin cytoskeleton. Action of toxin A is not due to proteolytical degradation of Rho or to an ...
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Formation of Prostaglandins during the Aggregation of Human Blood Platelets
... Prostaglandins E 2 and F 2a were formed in response to ADP, L-epinephrine, or collagen by human platelets suspended in plasma containing citrate anticoagulant and stirred at 37°C. The prostaglandins formed by ...
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Structural and Functional Basis for ADP-Ribose and Poly(ADP-Ribose) Binding by Viral Macro Domains
... in ADP-ribosylation or poly(ADP-ribose) polymerization, as well as in ATP-dependent chromatin re- modeling ...including ADP-ribose metabolism and post- translational protein ...
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Thymosin beta 4 treatment improves left ventricular function after myocardial infarction and is related to Up-regulation of chitinase 3-like-1 in mice
... ADP: Adenosine diphosphate; ADPase: Collective name for ADP hydrolyzing enzymes; AK: Adenylate kinase; Akt: Protein kinase B; ATP: Adenosine triphosphate; ATPase: Collective name for ATP[r] ...
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Identification and functional characterisation of a Schistosoma japonicum insulin like peptide
... antibody. ADP binding/hydrolysis ability was observed in both SjILP and SmILP, but not in human insulin, suggesting a parasite-specific role for ILP compared with host ...
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CYTOTOXICITY AND IN SILICO STUDIES OF ANETHOLE IN TRIPLE NEGATIVE BREAST CANCER CELLS
... (poly ADP-ribose polymerase) inhibitors, insulin- like growth factors (IGFs), vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR) and G-protein coupled receptor (GPCR) are some of ...
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ATP-induced Ca2+-signalling mechanisms in the regulation of mesenchymal stem cell migration
... In addition to being a physiological signal, extracellular ATP is known as a danger signal because a large quantity of ATP efflux can cause tissue damage and inflammation. Thus, almost all cell types have equipped with ...
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ELTA: Enzymatic Labeling of Terminal ADP-Ribose
... the ADP-ribose groups present in the PAR chain, these methods may not be useful for quantifying the differences between PAR of different chain ...cellular ADP-ribosylation ...
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The crystal structure of the Y140F mutant of ADP L glycero D manno heptose 6 epimerase bound to ADP beta D mannose suggests a one base mechanism
... Unsurprisingly, the mutant protein shares the same fold as wild-type AGME and is found arranged as a pentamer. There is no clear evidence that Cys78, which was found to be oxidized in the previous structure is oxidized ...
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