Adrenergic agonist
Expression of uncoupling protein in skeletal muscle and white fat of obese mice treated with thermogenic beta 3 adrenergic agonist
... The mitochondrial uncoupling protein (UCP) is usually ex- pressed only in brown adipose tissue (BAT) and a key mole- cule for metabolic thermogenesis. The effects of a highly se- lective b 3-adrenergic ...
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The beta-3 adrenergic agonist (CL-316,243) restores the expression of down-regulated fatty acid oxidation genes in type 2 diabetic mice
... in multiple tissues, or those caused by the administra- tion of the insulin sensitizing beta-3 adrenergic agonist (CL–316, 243). In this study, we aimed to uncover novel changes in metabolic tissues ...
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Enantioselective Quantification of Beta-Adrenergic Agonist: Isoxsuprine Hydrochloride
... Isoxsuprine hydrochloride, a beta-adrenergic agonist is a racemic mixture available in the market. As the drug consist of a single chiral center, two enantiomers were possible for it. The present work ...
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PRODUCT DEVELOPMENT OF OPHTHALMIC ALPHA 2 ADRENERGIC AGONIST SOLUTION
... Alpha-2-adrenergic agonist components include chemical entities, such as compounds, ions, complexes and the like, which are effective to act on or bind to alpha-2-adrenergic receptors and provide a ...
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Activation of heat shock protein (hsp)70 and proto oncogene expression by alpha1 adrenergic agonist in rat aorta with age
... under adrenergic control (4). In- travenous infusion of the adrenergic agonist phenylephrine into rats for 1 h markedly induced the expression of hsp70 mRNA in aorta which was blocked by the a 1 ...
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Effects of Dietary Beta-Adrenergic Agonist, Terbutaline, on Carcass Characteristics and Blood Attributes in Japanese Quails (Coturnix coturnix japonica)
... elevation of plasma FFA concentration following the administration of a beta agonist is an indication of activated adipocyte lipolytic system which may be originated from a hormone-sensitive lipase activity ...
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Quantification of the effects of an alpha-2 adrenergic agonist on reflex properties in spinal cord injury using a system identification technique
... This study was designed to help us understand the mechanisms of action of tizanidine on spasticity in spinal cord injured subjects with incomplete injury, by quantifying the effects of[r] ...
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Effect of β2-adrenergic receptor gene (ADRB2) 3′ untranslated region polymorphisms on inhaled corticosteroid/long-acting β2-adrenergic agonist response
... length polymorphism has been identified in a ‘C’ nucleo- tide-rich region 23 bp downstream from the translation stop codon of ADRB2 in the poly-C repeat region [16]. Results from a case-control study in a multiethnic ...
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β2 adrenergic agonist suppresses eosinophil-induced epithelial-to-mesenchymal transition of bronchial epithelial cells
... RT-PCR analysis showed that procaterol significantly inhibited the decrease in the expression of the epithelial marker E-cadherin and the increase in the expression of the mesenchymal ma[r] ...
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A dose-ranging study of the bronchodilator effects of abediterol (LAS100977), a long-acting β2-adrenergic agonist, in asthma; a Phase II, randomized study
... Conclusions: Abediterol 0.625 – 2.5 μ g provided dose-dependent, clinically and statistically significant bronchodilation versus placebo in patients with asthma, with a peak effect simil[r] ...
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Improved process for the preparation A Long acting β2 adrenergic agonist (LABA) Salmeterol and identification, characterization and control of its potential process impurity
... Salmeterol and its pharmaceutically acceptable salts are long-acting-beta-agonists. Salmeterol xinafoate is a selective β2-adrenoreceptor agonist. It is clinically used as a long-acting inhaled bronchodilator for ...
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Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK M) and serine biosynthetic pathway genes are co ordinately increased during anabolic agent induced skeletal muscle growth
... beta-adrenergic agonist (grey bars; BA) or recombinant growth hormone (black bars; GH) treatment for 1–27 days, compared to a control cohort (white bars; C); Phosphoglycerate Dehydrogenase: Phgdh (A), ...
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Cationic supramolecular hydrogels for overcoming the skin barrier in drug delivery
... Brimonidine tartrate Figure 1, an a2 adrenergic agonist, is commercialized as the carbopol-based gel MirvasoS for topical use in the treatment of rosacea, and it provides vasoconstrictio[r] ...
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Functional characterization of the alpha adrenergic receptor modulating the hydroosmotic effect of vasopressin on the rabbit cortical collecting tubule
... alpha adrenergic agonist, resulted in a significant decrease in Jv and Pf to ...alpha adrenergic antagonist, did not cause any significant change in Jv and Pf, which were ...2 adrenergic ...
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Norepinephrine stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response
... alpha adrenergic antagonist phentolamine and by the alpha 1 adrenergic antagonists prazosin and terazosin; it was not inhibited by propranolol or by the alpha 2 adrenergic antagonist ...beta ...
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Dynamin association with agonist mediated sequestration of beta adrenergic receptor in single cell eukaryote Paramecium
... -selective adrenergic agonist (–)- isoproterenol (Iso), previously shown to enhance phagocytic activity (Wyroba, 1989), evoked a redistribution of β AR analogue from the membranous (P2) to the cytosolic ...
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Pertussis toxin sensitive G proteins influence nitric oxide synthase III activity and protein levels in rat heart
... -adrenergic agonist isoproterenol, but also markedly increased protein abundance and activity of NOS III, measured functionally in isolated hearts and in ...
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Effect of adrenergic blocking or stimulating agents on plasma growth hormone, immunoreactive insulin, and blood free fatty acid levels in man
... insulin. This increase in plasma HGH was inhibited either by the combined administration of isoproterenol, a beta adrenergic-stimulating agent, along with propranolol or by oral glucose loading immediately before ...
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Apparent histological changes of adipocytes after treatment with CL 316,243, a ß-3-adrenergic receptor agonist
... body weight as compared with lean rats treated with saline. Treatment with CL significantly decreased both serum insulin and blood glucose levels in fa/fa rats (Figure 10A and B). Measurement of serum FAs also showed a ...
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Etanercept restores normal insulin signal transduction in β2-adrenergic receptor knockout mice
... Background: Inhibition of TNF α protects the retina against diabetic-like changes in rodent models. The mechanism by which TNF α induces deleterious retinal changes is not known. Previously, we have shown that TNF α can ...
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