adrenergic receptors
The roles of beta-adrenergic receptors in tumorigenesis and the possible use of beta-adrenergic blockers for cancer treatment: possible genetic and cell-signaling mechanisms
... -adrenergic receptors was demonstrated in the cell membranes of breast cancer cells by the significant increase in cyclic adenosine mono- phosphate (cAMP) production induced by different concentrations of ...
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Identification of beta adrenergic receptors in human lymphocytes by ( ) (3H) alprenolol binding
... mononuclear leukocytes. Binding of (-) [3H] alprenolol to these sites demonstrated the kinetics, affinity, and stereospecificity expected of binding to adenylate cyclase-coupled beta-adrenergic receptors. ...
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Neural modulation of salt secretion in teleostopercular epithelium by 2 adrenergic receptors and inositol 1,4,5 trisphosphate
... β-Adrenergic receptors are also present, and isoproterenol rapidly stimulates Cl − secretion, but nonspecific agonists evoke primarily the inhibitory response (Degnan et ...
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Beta adrenergic receptors in lymphocytes and granulocytes from patients with cystic fibrosis
... beta adrenergic receptors, as determined by equilibrium binding of [3H]dihydroalprenolol to granulocyte particulates, was the same in normal (1,462 +/- 249 receptors/cell) and CF (1,621 +/- 221 ...
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In Vitro Desensitization of Beta Adrenergic Receptors in Human Neutrophils ATTENUATION BY CORTICOSTEROIDS
... accumulation in the cells. Two types of receptor alterations were documented. There was a 40% reduction in the number of beta adrenergic receptors (42 vs. 25 fmol/mg protein, P < 0.005) present after ...
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Identification of α Adrenergic Receptors in Human Platelets by [3H]Dihydroergocryptine Binding
... Binding of [ 3 H]dihydroergocryptine to platelet lysates appears to have all the characteristics of binding to a-adrenergic receptors. At 25°C binding reaches equilibrium within 20 min and is reversible ...
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The α1A/C and α1B adrenergic receptors are required for physiological cardiac hypertrophy in the double knockout mouse
... 13. Rokosh, D.G., and Simpson, P.C. 2002. Knockout of the α1A/C-adrenergic receptor subtype: the α 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure. Proc. Natl. Acad. ...
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α1 adrenergic receptors activate Ca2+ permeable cationic channels in prostate cancer epithelial cells
... The prostate gland is a rich source of α1-adrenergic receptors (α1-ARs). α1-AR antagonists are com- monly used in the treatment of benign prostatic hyperplasia symptoms, due to their action on smooth muscle ...
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Noncoordinate regulation of cardiac Gs protein and beta adrenergic receptors by a physiological stimulus, chronic dynamic exercise
... beta-adrenergic receptors and the stimulatory guanine nucleotide-binding protein, ...beta-adrenergic receptors, but the dose of isoproterenol yielding a 50% maximal increase in heart rate was ...
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Pharmacological Characterizations of Adrenergic Receptors in Human Adipocytes
... of adrenergic receptors, beta, alpha-1, and alpha-2, were identified in human adipocytes, isolated from properitoneal adipose tissue, using both the binding of radioactive ligands and the effects of ...
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Positive coupling of beta like adrenergic receptors with adenylate cyclase in the cnidarian Renilla koellikeri
... Although Venturini et al. (1984) failed to detect any change in adenylate cyclase activity of the cnidarian Chlorohydra viridissima following exposure to serotonin and dopamine, adenylate cyclase activity in the ...
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Loss of high affinity cardiac beta adrenergic receptors in dogs with heart failure
... isoproterenol in the presence and absence of 5'-guanylylimidodiphosphate [Gpp(NH)p] demonstrated a striking loss of high affinity binding sites in heart failure (51 +/- 16 to 11 +/- 5%). Beta-Adrenergic ...
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In vivo and in vitro assessment of cardiac β adrenergic receptors in larval zebrafish (Danio rerio)
... - adrenergic receptors (1AR, 2aAR, 2bAR) was determined using semi-quantitative real-time PCR and qualitative in situ ...of adrenergic ligands to determine any heart rate and cardiac output ...
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Exercise induced pulmonary vasoconstriction during combined blockade of nitric oxide synthase and beta adrenergic receptors
... of adrenergic receptors occurs with exercise, and because increased release in NO is hypothesized to occur during exercise, these studies were designed to determine the magnitude of effect and interactions ...
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Direct relationship between mononuclear leukocyte and lung beta adrenergic receptors and apparent reciprocal regulation of extravascular, but not intravascular, alpha and beta adrenergic receptors by the sympathochromaffin system in humans
... beta-adrenergic receptors by the sympathochromaffin system was only demonstrable with adrenergic receptor measurements in the extravascular catecholamine target ...alpha- adrenergic receptor ...
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Original Article Beta-3 adrenergic receptors could be significant factors for overactive bladder-related symptoms
... two adrenergic receptors (ARs) and one muscarinic receptor for this research in OAB patients since the α1-a and α1-d AR subtypes are related to urination, the former mainly located in the prostatic urethra ...
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Cardiac /3-Adrenergic Receptors in Salt-Dependent Genetic Hypertension CATHERINE LIMAS AND CONSTANTINOS J. LIMAS
... 5 - 68 - "• 2| - 23 In this respect, our demonstration of enhanced numbers of cardiac /3-adrenergic receptors and isoproterenol- stimulated adenylate cyclase in salt-loaded DS is of[r] ...
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Beta Adrenergic Receptors of Polymorphonuclear Particulates in Bronchial Asthma
... In further studies we examined the interaction of the agonist (−)-isoproterenol with beta adrenergic receptors in 8 normal subjects and 10 asthmatics not receiving adrenergic medication. We tested ...
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Biphasic Adrenergic Modulation of β Adrenergic Receptors in Man: AGONIST INDUCED EARLY INCREMENT AND LATE DECREMENT IN β ADRENERGIC RECEPTOR NUMBER
... b-Adrenergic receptors in mononuclear leukocyte preparations were assessed with (−)[ 3 H]- dihydroalprenolol binding studies during the infusion of adrenergic agonists into normal human ...
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Rapid desensitization of neonatal rat liver beta adrenergic receptors A role for beta adrenergic receptor kinase
... Exposure of beta-adrenergic receptors (BAR) to agonists often leads to a rapid loss of receptor responsiveness. The proposed mechanisms of such rapid receptor desensitization include receptor ...
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