Adrenocortical Carcinoma
Original Article Tob1 is low-expressed in adrenocortical carcinoma and regulates steroidogenic enzymes expression and cell apoptosis of human adrenal cortical cell
... mal hormonal production [7]. IFN-β possesses anti-tumor effect and has been reported to inhibit cell growth and cortisol secretion in human adrenocortical carcinoma cells [22]. IFN-β also inhibited the ...
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Adrenocortical carcinoma in a 8 years old child: a Case Report
... 9. Zancanella P, Pianovski MA, Oliveira BH, Ferman S, Piovezan GC, Lichtvan LL, et al. Mitotane associated with cisplatin, etoposide and doxorubicin in advanced childhood adrenocortical carcinoma: mitotane ...
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Images: Port site recurrence on followup imaging after adrenalectomy for adrenocortical carcinoma — first indicator of carcinomatosis
... grade, adrenocortical carcinoma, stage pT2 (> 5cm, no extra-adrenal invasion) NX M0, as designated by the American Joint Committee on Cancer ...an adrenocortical malignancy including diffuse ...
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Mitotane in the treatment of childhood adrenocortical carcinoma: a potent endocrine disruptor
... Adrenocortical carcinoma (ACC) during childhood is a rare malignant tumor that frequently results in glucocorticoid and/or androgen excess. When there are signs of microscopic or macroscopic residual ...
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Nonfunctional adrenocortical carcinoma initially presenting as retroperitoneal hemorrhage
... retroperitoneal fatty tissue, the tumor was removed en bloc by partially excising Gerota’s fascia, without leaving any remnants. No invasion into the surrounding organs, lymph node metastasis, or liver metastasis was ...
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Bilateral adrenocortical carcinoma in a patient with multiple endocrine neoplasia type 1 (MEN1) and a novel mutation in the MEN1 gene
... The preoperative hormonal evaluation of the patient is presented in Table 1. She was further submitted to an Overnight Dexamethasone Suppression Test (ODST), which failed to suppress the morning cortisol levels- which ...
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Aldosterone-producing adrenocortical carcinoma with myxoid differentiation in a cat
... aldosterone-producing adrenocortical carcinoma with myxoid ...of adrenocortical carcinomas has been found in other species and can pose a major diagnostic challenge on microscopic ...
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Adrenocortical carcinoma presenting as varicocele and renal vein thrombosis: a case report
... Introduction: Adrenocortical carcinomas are rare aggressive ...large adrenocortical carcinoma that presented as testicular pain, varicocele, and acute kidney injury secondary to renal vein ...
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Nicotinamide nucleotide transhydrogenase as a novel treatment target in adrenocortical carcinoma
... Chortis, Vasileios, Taylor, Angela E., Doig, Craig L., Walsh, Mark David, Meimaridou, Eirini, Jenkinson, Carl, Rodrigues-Blanco, Giovanny, Ronchi, Cristina L., Jafri, Alisha, Metherell, Louise A., Hebenstreit, Daniel, ...
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Diagnostic and prognostic features in adrenocortical carcinoma: a single institution case series and review of the literature
... reticulin/basal membrane network. Any tumor with a disrupted reticulin framework as well as the presence of mitosis >5/50 HPFs, necrosis, or venous invasion meets the algorithm’s criteria and is considered malignant ...
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A case report of a solitary pancreatic metastasis of an adrenocortical carcinoma
... Here we report for the first time a case of a solitary pancreatic metastasis of an adrenocortical carcinoma. ACC is one of the most aggressive endocrine tumors known so far. Resection of recurrent tumor is ...
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Targeting heterogeneity of adrenocortical carcinoma: Evaluation and extension of preclinical tumor models to improve clinical translation
... In recent years it has been recognized that clinical translation of novel therapeutic strategies for patients with adrenocortical carcinoma (ACC) often fails. These disappointing results indicate that the ...
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microRNA-7 as a tumor suppressor and novel therapeutic for adrenocortical carcinoma
... Adrenocortical carcinoma (ACC) has a poor prognosis with significant unmet clinical need due to late diagnosis, high rates of recurrence/metastasis and poor response to conventional ...
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Delayed Diagnosis and False Relapse Due to Paternal Testosterone Use in Adrenocortical Carcinoma
... pediatric adrenocortical carcinoma often depends on prompt diagnosis to begin treatment before metastatic ...metastatic adrenocortical carcinoma was ...
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Survival and prognostic factors for adrenocortical carcinoma: a single institution experience
... The more frequent clinical use of ultrasound and comput- erized tomography have increased the detection of adrenal tumours. Such adrenal incidentalomas are usually benign adenomas. Adrenocortical carcinoma ...
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Chloroquine enhances the efficacy of cisplatin by suppressing autophagy in human adrenocortical carcinoma treatment
... Background: It has been demonstrated that chloroquine (CQ) enhances the efficacy of chemotherapy. However, little is known about whether CQ could enhance the efficacy of cisplatin (DDP) in the treatment of ...
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The impact of patient , disease , and treatment related factors on survival in patients with adrenocortical carcinoma
... 11. Pennanen M, Heiskanen I, Sane T, et al. Helsinki score-a novel model for prediction of metastases in adreno- cortical carcinomas. Hum Pathol 2015;46:404-10. https://doi.org/10.1016/j.humpath.2014.11.015 12. Pinheiro ...
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The challenge of developmental therapeutics for adrenocortical carcinoma
... Adrenocortical carcinoma (ACC) is a rare disease with an estimated incidence of only 0.7 new cases per million per year. Approximately 30-70% of the patients present with advanced disease with very poor ...
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Cushing Syndrome Revealing an Adrenocortical Carcinoma
... Adrenocortical carcinoma is a malignant tumor of the adrenal gland, very rare in pediatric ...of adrenocortical carcinoma which showed neurology symptoms at 1st visit and Cushing syn- drome ...
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Adrenocortical carcinoma masquerading as pheochromocytoma: a histopathologic dilemma
... Adrenocortical carcinoma (ACC) is an aggressive cancer that originates in the cortex of the adrenal gland and generally has a poor ...renal carcinoma, or hepatocellular ...
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