Advanced glycation end-product
Carboxymethyllysine, an Advanced Glycation End-Product, Promotes the Invasion and Migration of Lung Cancer A549 Cells
... Carboxymethyllysine (CML) is an advanced glycation end-product (AGE). CML and other AGEs could be detected in many processed foods including canned meats, nuts or grain products [1]. It is ...
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Imaging receptor for advanced glycation end product expression in mouse model of hind limb ischemia
... RAGE is a 35 kDa polypeptide of the immunoglobulin superfamily that is a multiligand receptor shown to play an important role in vascular disease [2-11]. This receptor is constitutively expressed in low levels on smooth ...
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The Contribution of Advanced Glycation End product (AGE) accumulation to the decline in motor function
... consequences. Advanced Glycation End products (AGE ’ s) may contribute to age-related decline in the function of cells and tissues in normal ...
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Immunohistochemical detection of imidazolone, a novel advanced glycation end product, in kidneys and aortas of diabetic patients
... Incubation of 3-DG with proteins leads to the formation of pyrraline (26) and pentosidine (27), which have been identi- fied in human tissue proteins such as collagen and lens pro- teins. 3-DG has also been suggested to ...
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Effect of pseudophosphorylation and cross-linking by lipid peroxidation and advanced glycation end product precursors on Tau aggregation and filament formation
... Neurofibrillary tangles are major hallmarks of a variety of neurodegenerative diseases, and elucidation of the mechanisms of their formation may provide targets for future therapies. Two main post-translational ...
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Blockade of advanced glycation end product formation attenuates bleomycin-induced pulmonary fibrosis in rats
... [1]. Advanced glycation end products (AGEs), the irreversible products of nonenzymatic glycation of proteins, nucleic acids and lipids, are increased in situations with hypergly- cemia and ...
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Impairment of glyoxalase 1, an advanced glycation end product detoxifying enzyme, induced by inflammation in age related osteoarthritis
... dine have also been reported [8]. AGE formation increases in some pathological conditions, such as diabetes mellitus [9]. Importantly, AGE formation is irreversible, leading to tissue accumulation and ultimately ...
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Longistatin in tick saliva blocks advanced glycation end product receptor activation
... for advanced glycation end products (RAGE) mediates immune cell activation at inflammatory sites and is constitutively and highly expressed in ...
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Advanced glycation end product (AGE) damaged IgG and IgM autoantibodies to IgG AGE in patients with early synovitis
... nine). Subsequently, Amadori rearrangements occur with the formation of ketoamine and finally the advanced glyca- tion end-products (AGEs), which are stable. These AGEs include a large number of chemical ...
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Immunological Detection of a Novel Advanced Glycation End-Product
... our knowledge about the heterogeneous AGEs formed in vivo is limited and many of these products are still largely undefined at the chemical level (17). 3-DG may be formed non-enzymatically from Amadori compounds or ...
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<p>Loratadine Alleviates Advanced Glycation End Product-Induced Activation of NLRP3 Inflammasome in Human Chondrocytes</p>
... 2 Advanced glycation end products (AGEs) are glycated compounds generated from the reaction between reducing sugars and amine residues on proteins or ...
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Modulating impacts of quercetin and/or lactoferrin on diabetic nephropathy and cardiomyopathy induced rats
... of advanced glycation end products (AGEs), connective tissue growth factor (CTGF) and the creation of a proinflammatory ...of advanced glycation end product , connective ...
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Soluble RAGE and atherosclerosis in youth with type 1 diabetes: a 5-year follow-up study
... AGE: advanced glycation end product; RAGE: receptor for AGEs; esRAGE: endogenous secretory RAGE; sRAGE: soluble RAGE; MG‑H1: methylglyoxal‑ derived hydroimidazolone‑1; CML: ...
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Immunization with advanced glycation end products modified low density lipoprotein inhibits atherosclerosis progression in diabetic apoE and LDLR null mice
... AGE-LDL: Advanced glycation end product -modified low-density lipoprotein; AGEs: Advanced glycation end products; Alum: Aluminum hydroxide; APES: ...
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The differentiation of mesenchymal stem cells to vascular cells regulated by the HMGB1/RAGE axis: its application in cell therapy for transplant arteriosclerosis
... In this scenario, we have been exploring ways of improv- ing the efficacy of MSC transplantation with a special focus on the regulation of cell differentiation that would promote endothelial regeneration. The current ...
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The effects of pigment epithelium-derived factor on atherosclerosis: putative mechanisms of the process
... AGE: Advanced glycation end product; AMI: Acute myocardial infarction; AMPK: AMP-activated protein kinase; ATGL: Adipose triglyceride lipase; ATP: Adenosine triphosphate; BNP: Brain ...
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Advanced Glycation End Products: A Molecular Target for Vascular Complications in Diabetes
... Nitric oxide (NO) is the most potent endogenous vasodilator and, by the role of its antiinflammatory, antiproliferation and antithrombotic effects, it is widely recognized as an endogenous antiathero- genic factor ...
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Advanced glycation end products cause epithelial myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE)
... ber of the immunoglobulin superfamily is the best characterized of the AGE receptors (37). Purified RAGE migrates as a single band on SDS-PAGE, but has been shown to appear as a doublet due to posttranslational ...
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A STUDY ON THE ROLE OF DIETARY AGENT MOMORDICA CHARANTIA L ON PROTEIN GLYCATION
... The data of the present study suggest that co- incubation of the M. Charantia L. extract with HSA-fructose mixture intensify the fructose mediated glycation of HSA. The tryptophan fluorescence studies revealed ...
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Clinical biomarkers and molecular basis for optimized treatment of diabetic retinopathy: current status and future prospects
... of advanced glycation end-products, abnormal activation of signaling cascades such as activation of protein kinase C (PKC) pathway, increased hexosamine pathway flux, and peripheral nerve ...
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