advanced rectal cancer
A Phase II Trial of Preoperative Chemoradiotherapy with Oral DPD Inhibitory Fluoropyrimidines in Patients with Advanced Rectal Cancer
... Background: Preoperative chemoradiotherapy (CRT) with 5-FU has been widely used to improve local control of dis- ease and to preserve anal sphincter in the treatment of rectal cancer. UFT and S-1 as oral ...
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Feasibility of purely laparoscopic resection of locally advanced rectal cancer in obese patients
... Between July 2007 and March 2010, 26 patients with lo- cally advanced rectal cancer (T3 or T4) underwent re- section using TLRR. Preoperative staging included endorectal ultrasonography, ...
5
Neoadjuvant chemoradiation for locally advanced rectal cancer: a systematic review of the literature with network meta-analysis
... The present NMA evaluated the eight CRT regimes that are currently used to treat locally advanced rectal cancer, with regard to efficacy (defined as pCR) and toxicity. Fourteen RCTs were included in ...
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Surgical outcome following Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer.
... locally advanced rectal cancer (LARC), lymph node involvement and positive resection margins are common, leading to local recurrence and metastatic ...unresectable rectal cancers, a high risk ...
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Predictive role of microRNA-related genetic polymorphisms in the pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients
... In rectal cancer, a pathologic complete response (pCR) to pre-operative treatment is a favourable prognostic marker, but is reported in a minority of the ...locally advanced rectal ...
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Therapeutic effects of oxaliplatin based neoadjuvant chemotherapy and chemoradiotherapy in patients with locally advanced rectal cancer: a single center, retrospective cohort study
... Therapeutic strategies for locally advanced rectal cancer (LARC) have evolved significantly during the last three decades. In Western countries, neoadjuvant chemoradio- therapy (NACRT) followed by ...
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Circulating serum microRNA-345 correlates with unfavorable pathological response to preoperative chemoradiotherapy in locally advanced rectal cancer
... Preoperative chemoradiotherapy (pre-CRT) has been represented as the standard treatment for locally advanced rectal cancer (LARC), but large variations of tumor radiation response to CRT have been ...
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<p>Systemic inflammation score in locally advanced rectal cancer patients following total mesorectal excision</p>
... in rectal cancer should be evaluated prospectively in other populations and larger cohorts in the ...of rectal cancer recommend either XELOX or FOLFOX as standard of care treatment ...
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The prognostic capacities of CBP and p300 in locally advanced rectal cancer
... with rectal adenocarcinoma via immunohistochemistry, and the findings were compared with clinicopathological para- meters, including patient outcome, to investigate the clinical impacts and functions of both the ...
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Health economic evaluation of watch and wait policy after clinical complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients
... colorectal cancer), professor in radiology (specialized in oncologic diagnostics of the abdominal region), professor in oncology, professor in nuclear medicine, and stoma ...stage rectal cancer ...
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Clinical Trial of Oral Nelfinavir Before and During Radiation Therapy for Advanced Rectal Cancer
... Nelfinavir, a PI3-kinase pathway inhibitor, is a radiosensitizer which increases tumor blood flow in preclinical models. This early-phase study demonstrates the safety of nelfinavir combined with radiation therapy (RT) ...
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Neoadjuvant oxaliplatin and capecitabine combined with bevacizumab plus radiotherapy for locally advanced rectal cancer: results of a single-institute phase II study
... Survival results were also promising in the present study, with a 3-year PFS rate of 88.6% and a 3-year OS rate of 95.3%, indicating effective control over both locoregional and distant diseases. Three explanations may ...
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First report on clinicopathological characteristics, histological response to neoadjuvant therapy and survival outcomes of patients with locally advanced rectal cancer in north est of Morocco
... a complete regression and 242 (82.8%) presented an incomplete regression in which 8 (3.6%), 42 (16.6%), 78(31.2%), 79 (31.6%) were classified Dworak 0, 1, 2, 3 respectively. After neoadjuvant treatment, 43 (17.2%) ...
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Locally advanced rectal cancer; preoperative chemo radiotherapyoutcome and tolerability; center experience
... even lower than those reported in prospective trials using adjuvant therapy (Kulinna, 2004; Allaix et al., 2013; Meredith et al., 2009; Heald et al., 2006; Taylor et al., 2011) TME is a complete, precise, and sharp ...
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Neoadjuvant treatment strategies for locally advanced rectal cancer
... for rectal cancer is surgery although pelvic local recurrence (LR) has historically been a major cause of morbidity and ...low rectal cancers [2], together with the selective use of pelvic ...
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A Review of Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer
... early rectal cancer (T1-T2N0) and over estimation of staging by preoperative clinical imaging [18], which will lead to certain blindness in selecting the treatment ...
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Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer
... in advanced colorectal cancer and on preoperative radiotherapy and multimodality treatment response evaluation in primary rectal cancer indicate that 18F-FDG PET is a significant predictor of ...
68
Locally advanced rectal cancer: management challenges
... an improvement of symptoms and was able to ambulate when discharged from hospital, but two died within 16 months of surgery due to recurrence or metastasis. The third patient was only followed-up for 7 months. Shaikh et ...
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Preoperative chemoradiation with capecitabine, irinotecan and cetuximab in rectal cancer: significance of pre-treatment and post-resection RAS mutations
... In summary, the regimen studied was feasible and met its primary R0 resection endpoint. Using the sensitive technology of NGS, comparing biopsy with resection, we describe for the first time substantial loss and gain of ...
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Future directions in combined modality therapy for rectal cancer: reevaluating the role of total mesorectal excision after chemoradiotherapy
... develop rectal cancer present with locoregionally advanced (T3 or node-positive) ...locoregionally advanced rectal cancer is neoadjuvant concurrent chemoradiotherapy (nCRT), ...
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