African trypanosomes
Insect Stage-Specific Adenylate Cyclases Regulate Social Motility in African Trypanosomes
... T rypanosoma brucei and other African trypanosomes are proto- zoan parasites that cause sleeping sickness in humans and re- lated wasting diseases in wild and domestic animals. Sleeping sick- ness is ...
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Review on Immunity to African Trypanosomes
... with African trypanosomes which provides an insight on how the possible mechanisms by which African trypanosomes can be ...with African trypanosomes, the balance between Th1 ...
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Loop Mediated Isothermal Amplification for Detection of African Trypanosomes
... African trypanosomes are medically and agriculturally im- portant protozoan parasites that cause sleeping sickness in humans and nagana in ...Since African trypanosomosis is fatal if left untreated ...
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De Novo Sphingolipid Synthesis Is Essential for Viability, but Not for Transport of Glycosylphosphatidylinositol-Anchored Proteins, in African Trypanosomes
... however, African trypanosomes are crit- ically dependent on de novo synthesis of ...that trypanosomes also acquire ethanolamine via the SPL pathway, but clearly sphin- goid base synthesis is required ...
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A molecular mechanism for eflornithine resistance in African trypanosomes
... We have found that the loss of a single gene, TbAAT6, is sufficient to render African trypanosomes resistant to the only safe drug, eflornithine, in use against them. The fact that parasites lacking TbAAT6 ...
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The Krebs Cycle Enzyme α-Ketoglutarate Decarboxylase Is an Essential Glycosomal Protein in Bloodstream African Trypanosomes
... Organisms use a wide array of mechanisms to compensate for a seemingly limitless need for biological diversity in the face of rather limited genetic potential. Generation of functionally dis- tinct proteins from a single ...
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Nucleosomes Are Depleted at the VSG Expression Site Transcribed by RNA Polymerase I in African Trypanosomes
... [rDNA]). African trypanosomes have the unique property of using Pol I to also transcribe the variant surface glycoprotein VSG ...allows trypanosomes to escape the host immune system, a mechanism ...
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IMMUNE RESPONSE OF HOSTS AND PROSPECTS OF VACCINE DEVELOPMENT AGAINST AFRICAN TRYPANOSOMES: THE REVIEW
... African trypanosomes are hemoprotozoa that cause disease in humans and ...glycoprotein. African trypanosomes are exposed to the host immune system from the time of infection and the immune ...
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Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes
... of African trypanosomes, which are of great medical and economic importance in ...man African trypanosomiasis or HAT) is caused by two distinct subspecies of the African trypanosomes ...
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Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes
... of African trypanosomes, which are of great medical and economic importance in ...man African trypanosomiasis or HAT) is caused by two distinct subspecies of the African trypanosomes ...
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Review on Immunity to African Trypanosomes
... with African trypanosomes which provides an insight on how the possible mechanisms by which African trypanosomes can be ...with African trypanosomes, the balance between Th1 ...
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Glucose Signaling Is Important for Nutrient Adaptation during Differentiation of Pleomorphic African Trypanosomes
... Bloodstream form parasites rapidly deplete glucose from the environment. Responses to new environments are particularly important to parasitic microbes that inhabit different hosts during their life cycles. As ...
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African trypanosomes
... of African trypanosomes is tied to interactions with their host, at least until they can escape to another host via their tsetse fly ...mechanism, trypanosomes also interact with the host immune ...
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The burden and spatial distribution of bovine African trypanosomes in small holder crop livestock production systems in Tororo District, south eastern Uganda
... of African trypanosomes in crop-livestock production systems in Tororo District, south-eastern Uganda, cattle blood sam- ples were taken and tested for different trypanosomes be- tween September and ...
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Cyclic AMP Regulates Social Behavior in African Trypanosomes
... ABSTRACT The protozoan parasite Trypanosoma brucei engages in surface-induced social behavior, termed social motility, characterized by single cells assembling into multicellular groups that coordinate their movements in ...
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Targeting the Variable Surface of African Trypanosomes with Variant Surface Glycoprotein-Specific, Serum-Stable RNA Aptamers
... African trypanosomes cause sleeping sickness in humans and Nagana in cattle. The parasites multiply in the blood and escape the immune response of the infected host by antigenic variation. Antigenic ...
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Endosomal Localization of the Serum Resistance-Associated Protein in African Trypanosomes Confers Human Infectivity
... As with transferrin, these live cell binding studies also showed flagellar pocket localization of bound Alexa Fluor 594 anti-Ty, indicating that SRA traffics to the cell surface of trypa[r] ...
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The best practice for preparation of samples from FTA®cards for diagnosis of blood borne infections using African trypanosomes as a model system
... if trypanosomes clumped in particular areas of the ...of trypanosomes from FTA card and this could provide an approach for measuring trypanosome populations from FTA ...of trypanosomes present in the ...
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Blood brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease
... ear regression of the hydrolysis curves. To discriminate the activity of papain-like cysteine proteases from other proteases (e.g., serine proteases), samples were incubated with 2 μ M E-64 and the residual activity was ...
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Evidence that low endocytic activity is not directly responsible for human serum resistance in the insect form of African trypanosomes
... Background: In Trypanosoma brucei , the African trypanosome, endocytosis is developmentally regulated and substantially more active in all known mammalian infective stages. In both mammalian and insect stages ...
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