Aging and cell senescence
Anti Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations
... anti- aging genes have accelerated in recent years to delay and prevent programmed cell death linked to the various chronic diseases (Figure ...with cell senescence (mitochondrial apoptosis) ...
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Do tumor suppressive mechanisms contribute to organism aging by inducing stem cell senescence?
... cancer cell maintains proper telomere function and growth potential, and the continuous telomerase expression that is needed for tumor ...each cell division ...
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Null cell senescence and its potential significance to the immunobiology of aging
... null cell compartments of human bone marrow and mouse spleen were arbitrarily divided into three subpopulations based upon the ability of cells to acquire T or B cell membrane markers when incubated with ...
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Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence
... metabolism, cell survival and cell growth [40] (Figure ...the cell, mTOR complex 1 and 2 (mTORC1 and mTORC2, respectively), reviewed in ...in senescence have been limited, and focused on its ...
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Antioxidants inhibit cell senescence and preserve stemness of adipose tissue-derived stem cells by reducing ROS generation during long-term in vitro expansion
... on cell viability and migration, as well as the multidir- ectional differentiation and stemness of ADSCs during the long-term in vitro ...the cell senescence and preserving stemness of ADSCs, ROS, ...
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Multiple therapeutic effect of endothelial progenitor cell regulated by drugs in diabetes and diabetes related disorder
... Cellular aging is caused due to the transport of telomerase reverse transcriptase (TERT) from nucleus to cytoplasm with the increase in the generation of ...cellular senescence associated with the EPCs ...
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T cell senescence and CAR-T cell exhaustion in hematological malignancies
... T cell senescence by enhancing telomerase activity and telomere-length restoration to extend cellular lifespan and prevent telomere-dependent T cell senescence [79, ...T cell pool by ...
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Microglia in the aging brain: relevance to neurodegeneration
... replicative senescence, leading to the substantial changes in cell function and gene ...of cell senescence, occurs in rat microglia overtime in vitro [52], as well as in vivo in rat cerebellum ...
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DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging
... [13]. Senescence per se has long been known to be a mechanism halting the replication of cells that have acquired potentially hazardous genetic mutations [2, ...that cell senescence is crucially ...
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The effects of astragalus polysaccharide on zebrafish cell apoptosis and senescence
... Current studies suggest that development of anti-aging drugs from Chinese medical herbs may be one of the po- ssible interventions [10,35]. AP has a variety of biologi- cal activities and pharmacological functions ...
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Cell-penetrating superoxide dismutase attenuates oxidative stress-induced senescence by regulating the p53-p21<sup>Cip1</sup> pathway and restores osteoblastic differentiation in human dental pulp stem cells
... the cell uptake studies clearly demonstrate that LMWP can deliver SOD1 effectively to the DPSC ...the cell within 30 minutes and remained unchanged until 6 ...determined cell viability by MTT assay ...
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NF κB inhibition delays DNA damage–induced senescence and aging in mice
... to aging-related degen- erative changes, but how damage drives aging is ...accelerated aging caused by a defect in DNA ...with aging and aging-related chronic ...drives aging in ...
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p53 isoforms regulate aging and tumor associated replicative senescence in T lymphocytes
... replicative senescence (15), consistent with their modes of functional interaction with ...cellular senescence in vivo and whether they can be a therapeutic target for functional restoration of senescent or ...
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Aging with ING: a comparative study of different forms of stress induced premature senescence
... Young fibroblasts were exposed to 70 μM of t-butyl-hydroperoxide that was freshly diluted in growth medium. The cells were exposed to this concentration of t-BHP for 1 hour every day for 7-8 days. After 1 hour exposure ...
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Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes
... organismal aging, as well as in age-related diseases, Mikhail Blagosklonny has predicted that rapamycin might extend lifespan, by slowing aging and delaying age-related diseases ...the cell cycle was ...
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Eliminating senescent chondrogenic progenitor cells enhances chondrogenesis under intermittent hydrostatic pressure for the treatment of OA
... CPCs aging had influence on the outcome of joint distraction arthroplasty, we collected cartilage samples from the patients subjected to ankle joint distraction ...CPCs senescence and SASP secretion were ...
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mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases
... Passed phase I initial dose discovery trial [93]; modest efficacy in advanced or metastatic carcinoma in phase II [94] but poorly tolerated in advanced pancreatic neuroendocrine tumour patient phase II study [95]; ...
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miR-125b induces cellular senescence in malignant melanoma
... cellular senescence in a MM cell line Mel-Juso, both in vitro and in a xenotransplantation model in mice in ...Mel-Juso cell line with the miRVec-125b vector previously developed by Voorhoeve et ...
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AUXIN RESPONSE FACTOR1 and AUXIN RESPONSE FACTOR2 regulate senescence and floral organ abscission in Arabidopsis thaliana
... Cells destined to become the abscission zone can be identified prior to separation by their morphology. Abscission zone cells are located at the base of floral organs and are typically smaller and more densely ...
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Senescence associated proteases: the key players in plant senescence
... and cell death responses during stress response in different organs (Hara-Nishimura et ...controlling cell death (Coll et ...the senescence-enhanced protease genes, isolated from maize, Arabidopsis ...
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