AIRE/CE
NF κB2 is required for the establishment of central tolerance through an Aire dependent pathway
... Self tolerance is a fundamental property of the immune system. Thymic negative selection provides a critical mechanism for establishing self tolerance by eliminating the self-reactive T cell repertoire. How autoreactive ...
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AIRE polymorphism, melanoma antigen-specific T cell immunity, and susceptibility to melanoma
... either the TT or the CC genotype of AIRE gene in 100 µl final volume of culture medium. Non-adherent cells were, then, harvested, viable cells counted by 7AAD exclusion, and stained with FITC annexin V kit as well ...
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Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire
... in Aire can act in an autosomal dominant fashion and provide mechanistic insights into this ...in Aire can confer a dominant- negative effect with a disease phenotype altered from that seen in ...
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Estrogen mediated downregulation of AIRE influences sexual dimorphism in autoimmune diseases
... sion in immune cells after puberty in mice is mediated through the estrogen pathway (75–77). These estrogen effects are medi- ated through 2 nuclear receptors, ERα and ERβ, both expressed at various levels in most immune ...
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Novel insight into Chronic Inflammatory Demyelinating Polineuropathy in APECED syndrome: molecular mechanisms and clinical implications in children
... of Aire action ...of Aire, so that decreased P0 expression would be detected in mTECs from Aire deficient ...in Aire-deficient thymus, increased T cell reactivity to P0 was seen in the spleen ...
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Aire controls gene expression in the thymic epithelium with ordered stochasticity
... of Aire-controlled genes may be found in the small clusters of co-regulated genes whose expression is shared by discrete groups of ...that Aire-target selection within a mTEC clone is “bookmarked” across ...
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Association of the AIRE gene with susceptibility to rheumatoid arthritis in a European population: a case control study
... the AIRE protein; hence, other non-synonymous SNPs could con- tribute to the ...of AIRE are lower for the rs878081C risk allele ...the AIRE gene in the thymus, contributing to the maintenance of ...
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Les noms d’humains en aire : essai de classification
... perspective, ce travail sur les NH en -aire aura abouti à quatre résultats : i) la constitution d’un inventaire stable des NH-aire, ii) la révision du classement essentiellement ontologique élaboré ...
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LYN and AIRE mediated tolerance checkpoint defects synergize to trigger organ specific autoimmunity
... In summary, in order to gain insights into the mechanisms of multigenic autoimmune susceptibility, we created a novel model of digenic autoimmune susceptibility and found that a surprising- ly restricted organ-specific ...
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Alteration of intra pancreatic target organ specificity by abrogation of Aire in NOD mice
... from Aire-deficient NOD mice showed reduced expres- sion of several tissue-specific genes, including insulin, as observed in non–autoimmune-prone mouse backgrounds (13, 14, ...in Aire-deficient NOD mice, ...
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The AIRE-230Y Polymorphism Affects AIRE Transcriptional Activity: Potential Influence on AIRE Function in the Thymus
... the AIRE transcription start site including AIRE minimal promoter for single nucleotide polymorphism (SNPs) and identified two SNPs -655R (rs117557896) and -230Y (rs751032) ...on AIRE promoter ...
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AIRE acetylation and deacetylation: effect on protein stability and transactivation activity
... if AIRE is deacetylated in ...that AIRE interacts with endogenous histone deacetylase 1 and histone deacetylase 2 (HDAC1, HDAC2), two targets for epigenetic repression that play an important role in ...
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AIRE deficiency in thymus of 2 patients with Omenn syndrome
... of AIRE expression in thymi of Omenn syndrome and SCID patients may account for the observed lack of tissue-specific antigens, such as insulin, cytochrome P450 1a2, and ...partial AIRE expression in thymus ...
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“Effects on the Phagocytosis Modulation of Roots Extract and Flavonoids from Allexis batangae (Violaceae)” by Nganso Ditchou Yves Oscar, Nkwengoua Tchouboun Zondegoumba Ernestine, Ndogo Eteme Olivier, Soh Desire, Nguefeu Nkenfou Celine, Nyasse Barthelemy, Cameroon.
... phagocytic activity of reticuloendothelial system after treatment of animals with increasing doses of AIRE. The phagocytic index obtained from animal groups ranged between 0.020 ± 0.004 and 0.074 ± 0.006. Compared ...
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Human skin cells support thymus independent T cell development
... www.cgi). AIRE primers were as follows: forward, 5′-GATGACCTG- GAGTCCCTTCT-3′; reverse, ...5′-CTCATCAGAGCTGCATGTCC-3′. AIRE primers were common to the 3 isomers of human ...
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Schaller, Claudia Eva Maria (2010): The Autoimmune Regulator (AIRE) and the Early Wave of Apoptosis in Spermatogenesis. Dissertation, LMU München: Fakultät für Biologie
... that AIRE is involved in the expression of peripheral-tissue antigens (PTA) by mTECs in the ...and Aire-deficient mice, which showed that AIRE indeed promotes transcription of a large number of ...
118
Constitution automatique d'une ressource morphologique : VerbAgent
... compte ce suffixe dans la formation de noms d'agents déverbaux parce qu'il nous a semblé qu'un certain nombre de relations entre un verbe et un nom en -aire pouvaient être pertinentes dans certaines tâches ...
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Autoimmune-mediated thymic atrophy is accelerated but reversible in RelB-deficient mice
... Polymorphisms impacting thymic function may decrease peripheral tolerance and hasten autoimmune disease. The NF- κ B transcription factor subunit, RelB, is essential for the development and differentiation of medullary ...
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Dominant Mutations in the Autoimmune Regulator AIRE Are Associated with Common Organ-Specific Autoimmune Diseases
... 22 more authors 2015 Dominant Mutations in the Autoimmune Regulator AIRE Are Associated with Common Organ-Specific Autoimmune Diseases.. Reuse Unless indicated otherwise, fulltext items [r] ...
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Est-ce l’âge d’arrêter?
... Dans notre cas, il semble raisonnable de deman- der à Jacques ce qu’il aimerait que son médecin fasse. Subirait-il une coloscopie si le TFI était positif? Chez un patient asymptomatique, le dépistage a pour but de ...
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