Airway epithelium
Genes associated with MUC5AC expression in small airway epithelium of human smokers and non-smokers
... small airway epi- thelium core MUC5AC genes have been previously associated with human airway MUC5AC expression, for most, this is the first demonstration that, in the human airways, these genes are ...
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Activation of Influenza A Viruses by Host Proteases from Swine Airway Epithelium
... with the endosomal membrane. HA is synthesized as precursor protein HA0, which must be cleaved by a host cell protease into the HA1 and HA2 subunits to gain its fusion capacity. Cleavage of HA exposes the hydrophobic ...
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Infection of Human Airway Epithelium by Human and Avian Strains of Influenza A Virus
... We describe the characterization of influenza A virus infection of an established in vitro model of human pseudostratified mucociliary airway epithelium (HAE). Sialic acid receptors for both human and avian ...
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Smoking accelerates aging of the small airway epithelium
... small airway epithelial brushes of non- smokers and smokers demonstrated epithelial cells were the major dominant cell population with a small amount of inflammatory ...small airway epithelial subjects ...
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Characterising and assessing the baseline functionality of the airway epithelium in preterm infants
... the airway epithelium have previously been observed when bronchial cells from subjects with cystic fibrosis were infected by bacteria or viruses ...of airway epithelial cells after infection with HRV ...
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The airway epithelium dysfunction in the pathogenesis of asthma: The evidence
... of airway are expression of inflammatory cell infiltration together airway ...the airway epithelium, airway smooth muscle, and endothelium, in both allergic and non-allergic forms of ...
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Inhibition of TGF alpha gene expression by vitamin A in airway epithelium
... The autocrine/paracrine growth mechanism has been impli- cated in the regulation of bronchial epithelial cell prolifera- tion. By inhibiting the expression of the transforming growth factor- a (TGF- a ) gene product, ...
8
SPDEF regulates goblet cell hyperplasia in the airway epithelium
... Clara cells caused their differentiation into goblet cells, decreased CCSP staining may be related to inhibition of Clara cell differenti- ation, rather than to its effect on the Scgb1a1 gene promoter. Alter- natively, ...
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Decreased microbiome diversity in the HIV small airway epithelium
... the pathogenesis of COPD, namely the small airway [7]. The small airway epithelium (SAE) is the first line of defense against toxins such as cigarette smoke and micro- bial pathogens. In COPD, ...
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Mitochondrial CaMKII inhibition in airway epithelium protects against allergic asthma
... Taken together with our earlier model of extramitochondrial CaMKII inhibition in airway epithelium (8), our data suggest subcellular specificity to CaMKII signaling in allergic asthma (57). Untargeted CaM- ...
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Adaptation of Human Parainfluenza Virus to Airway Epithelium Reveals Fusion Properties Required for Growth in Host Tissue
... ABSTRACT Paramyxoviruses, a family of RNA enveloped viruses that includes human parainfluenza virus type 3 (HPIV3), cause the majority of childhood croup, bronchiolitis, and pneumonia worldwide. Infection starts with ...
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Matrilysin expression and function in airway epithelium
... in airway epithelium and induced in alveo- lar type II cells in lungs from patients with cystic fibrosis ...tracheal epithelium was impaired in matrilysin-null ...by airway epithelial cells ...
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Particulate matter and the airway epithelium: the special case of the underground?
... The airway epithelium, as the principal site of PM deposition, is critical to the effects of, and initial response to, ...the airway epithelium, how the effects of underground PM may be ...
10
Myxovirus interaction with the human airway epithelium
... presence of glutamic acid at PB2 627 (avian-like) has been reported to account for the lower replication of avian influenza strains in mammalian cells and has been linked with reduced polymerase activity at lower ...
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Gene transfer into the airway epithelium of animals by targeting the polymeric immunoglobulin receptor
... immunoglobulin receptor. A DNA carrier, consisting of the Fab portion of polyclonal antibodies raised against rat secretory component covalently linked to poly-L-lysine, was used to introduce plasmids containing ...
11
The dopamine D1 receptor is expressed and induces CREB phosphorylation and MUC5AC expression in human airway epithelium
... human airway smooth muscle cells (HASM; cc-2576, Lonza) were grown in DMEM/ F12 culture medium, supplemented with 10% FBS and an antibiotic-antimycotic mix (100 units/ml penicillin G sodium, 100 μg/ml streptomycin ...
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The role of reactive oxygen and nitrogen species in the response of airway epithelium to particulates
... Abbreviations used: DMTU, dimethylthiourea; GM-CSF, granulocyte-macrophage colony stimulating factor; GPTE, guinea pig tracheal epithelial; H202, hydrogen peroxide; HO-, hydr[r] ...
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Intracellular reactive oxygen and nitrogen species as signaling molecules in airway epithelium
... The Role of Reactive Oxygen and Nitrogen Species in Airway Epithelial Gene Expression Author(s): Linda D. Martin, Thomas M. Krunkosky, Judith A. Voynow, Kenneth B. Adler Source: Environmental Health Perspectives, ...
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Functional Genomics of Mucin Secretion in the Airway Epithelium
... We report here a comparative proteomic analysis of mucin granule membranes from normal bronchial epithelial cells and a cystic fibrosis cell line, UNCN3T. We are attempting to elucidate the core molecules associated with ...
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Uptake and transport of B12 conjugated nanoparticles in airway epithelium
... Considering the recent emergence of biotherapeutics, developments in non-invasive delivery options for this class of medicines have been dis- appointing, with the parenteral method remaining the predominant ...
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