airway hyper-responsiveness
Forced Expiratory Flow at 25–75% as a Marker for Airway Hyper Responsiveness in Adult Patients with Asthma-like Symptoms
... bronchial hyper-responsiveness in patients with ...of airway hyper- responsiveness, it has its own limitations (in available and cost of procedure) that restrict its use as a tool for ...
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20-HETE Mediates Ozone-Induced, Neutrophil-Independent Airway Hyper-Responsiveness in Mice
... the exhaled breath condensate than subjects with less sensitive airways following an acute exposure to ozone [16]. In the present study, BAL fluid from mice exposed to ozone (6 ppm, 2 h, T = 0 h) was analyzed for ...
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Effects of Corni fructus on ovalbumin-induced airway inflammation and airway hyper-responsiveness in a mouse model of allergic asthma
... Briefly, the lung tissue was embedded in paraffin, cut into 3-μm-thick sections, and stained with H&E or M-T solution. The tissue was subsequently mounted and cov- erslipped with Dako mounting medium (Dakocytoma- ...
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Multiple exposures to swine barn air induce lung inflammation and airway hyper-responsiveness
... mucus hyper- secretion as a hallmark feature of airway ...reduced airway caliber, occlusion of small airways, reduced FEV1 [40], impaired gas exchange and compromised muco-ciliary clearance ...
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The relationship between inspiratory lung function parameters and airway hyper responsiveness in subjects with mild to moderate COPD
... esophageal reflux, which can induce BHR [25]. Third, some of the subjects had used inhaled corticosteroids (ICS). Withdrawal of ICS, which are known to reduce the maximal degree of airway narrowing, prior to ...
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A study of agastachis herba on ovalbumin-induced asthma in the mouse
... on airway hyper responsiveness, immune cell distributions in bronchoalveolar lavage fluid, ovalbumin‑specific immunoglobulin E in serum, and histopathological changes were ...of airway ...
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Interleukin-32: its role in asthma and potential as a therapeutic agent
... AHR: Airway hyper-responsiveness; AML: Acute myeloid leukemia; AR: Allergic rhinitis; BALF: Bronchoalveolar lavage fluid; BD: Behçet ’ s disease; CCL: CC chemokine ligand; CD: Crohn ’ s disease; ...
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Ingestion of milk containing the Dp2 peptide, a dust mite allergen, protects mice from allergic airway inflammation and hyper-responsiveness
... allergen-specific airway hyper- responsiveness and inflammation is shown in Figure ...of airway hyper-responsiveness in the three ex- perimental groups were measured 18 h after ...
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Anti-angiogenic Nanotherapy Inhibits Airway Remodeling and Hyper-responsiveness of Dust Mite Triggered Asthma in the Brown Norway Rat
... and airway hyper-responsiveness in HDM rats, suggesting for the first time that direct anti-neovascular therapy can contribute significantly to asthma ...
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Airway wall thickness is increased in COPD patients with bronchodilator responsiveness
... greater airway smooth muscle mass were more likely to demonstrate BDR on lung function testing ...CT airway thickness in the BDR groups may represent a greater degree of smooth muscle hypertrophy, which is ...
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Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma?
... in airway hyper-responsiveness are ...bronchial hyper-responsiveness by directly altering the contractile properties of the airway smooth muscle ...
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A Novel in vivo System to Test Bronchodilators
... asthma, airway hyper- responsiveness, and validate a system to test compounds to attenuate this response in an animal ...small airway closure independent of smooth muscle contraction ...in ...
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ASTHMA AND HERBAL DRUGS
... with airway hyper responsiveness that leads to recurrent episodes of wheezing, breathlessness, chest tightness and coughing, particularly at night or in the early ...
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Pharmacokinetics and Bronchopulmonary Disposition of PI3KDelta Inhibitor IC87114 after Intratracheal Administration in a Severe Asthma Model
... The reduction in airway hyper-responsiveness described above correlated with histological changes in the lung parenchyma. Lungs from OVA/LPS- sensitized/challenged mice exhibited widespread ...
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Effects of Nerve Growth Factor shRNA Inhibition on Asthma Phenotypes in a Mouse Model of Asthma
... alleviated airway hyper-responsiveness by preventing muscarinic acetylcholine receptor M3 overexpression and smooth muscle cell hyperplasia in a mouse asthma ...shRNA. Airway resistance (Raw) ...
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Anti-allergic Activity of Stem Bark of Myrica esculenta Buch.‑Ham. (Myricaceae)
... Consistent with these observations, we have found that amounts of plasma extravasation were greatly enhanced in a murine model of allergic airway disease. Interestingly, administration of EtMe inhibited vascular ...
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Aldose reductase deficiency in mice protects from ragweed pollen extract (RWE)-induced allergic asthma
... Background: Childhood hospitalization related to asthma remains at historically high levels, and its incidence is on the rise world-wide. Previously, we have demonstrated that aldose reductase (AR), a regulatory enzyme ...
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A theoretical model of inflammation and mechanotransduction driven asthmatic airway remodelling
... Inflammation, airway hyper-responsiveness and airway remodelling are well-established hallmarks of asthma, but their inter-relationships remain ...the airway wall accounting for local ...
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Mast cell activation enhances airway responsiveness to methacholine in the mouse
... responsiveness to Mch in both types of normal mice (P < 0.0001 by analysis of variance) but not in either genotype of mast cell-deficient mouse. Additionally, anti-IgE pretreatment of genetically mast ...
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Mechanism of rhinovirus induced changes in airway smooth muscle responsiveness
... altered airway epithelial cell function in the pathogenesis of asthma, the ASM itself constitutes an autologously regulated system which, when acti- vated in the sensitized state ...ASM responsiveness and ...
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