airway hyperresponsiveness
Zinc supplementation alters airway inflammation and airway hyperresponsiveness to a common allergen
... Results: Administration of zinc gluconate prior to allergen exposure resulted in significantly decreased neutrophil infiltration and TNFa cytokine release into the airways. This correlated with decreased NF- B activity ...
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Chlamydophila pneumoniae induces a sustained airway hyperresponsiveness and inflammation in mice
... However, no data have so far been obtained in demon- strating a role for C. pneumoniae infection in the pathogen- esis of airway hyperresponsiveness in vivo. In our study we evaluated the effect of acute C. ...
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Clinical implications of airway hyperresponsiveness in COPD
... “airway hyperresponsiveness” is not a MeSH term and is not recognized as an entry term for the MeSH “bronchial hyperreactivity”, which is the MeSH closest to the definition of AHR given ...adenosine, ...
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Respiratory syncytial virus infection results in airway hyperresponsiveness and enhanced airway sensitization to allergen
... with airway hyperresponsiveness as well as enhanced responses to sub- sequent sensitization to ...increased airway responsiveness to inhaled methacholine and pulmonary neutrophilic and eosi- nophilic ...
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Determinants of airway hyperresponsiveness—Balance of tonic and phasic contractility of airway smooth muscles of lobular bronchioles
... Airway hyperresponsiveness (AHR) is a characteris- tic feature of asthma, and generally correlates with severity of ...excessive airway narrowing and how it breaks down is fundamental to solving the ...
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Pulmonary C Fibers Modulate MMP-12 Production via PAR2 and Are Involved in the Long-Term Airway Inflammation and Airway Hyperresponsiveness Induced by Respiratory Syncytial Virus Infection
... persistent airway inflammation and ...of airway inflammation and resistance; however, their role in persistent airway diseases after RSV is ...study. Airway inflammation and airway ...
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Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice
... both airway inflammation and contractility (25, ...for airway contractility with Y16 provide proof of concept for targeting Arhgef12, but given its inhibition of Arhgef1 and Arhgef11 in addition (23), ...
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Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma
... Phosphatase and tensin homologue deleted on chromosome ten (PTEN) is part of a complex signal- ing system that affects a variety of important cell functions. PTEN blocks the action of PI3K by dephosphorylating the ...
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The contribution of L-selectin to airway hyperresponsiveness in chronic allergic airways disease
... of airway inflammation was assessed by examining leukocyte influx into bronchoalveolar lavage ...fluid. Airway remodeling changes were determined via histology and morphometric analysis of lung tissue ...
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Prevention of airway hyperresponsiveness induced by left ventricular dysfunction in rats
... the airway responsiveness to exogenous con- strictor stimuli and suggested an elevation of static lung ...against airway hyperresponsiveness due to pulmonary vascular engorge- ment than on the rather ...
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Is Obesity Associated with an Increased Risk for Airway Hyperresponsiveness and Development of Asthma?
... Although obesity and asthma remain two of the fastest growing and most pervasive public health problems in developing countries, the question remains whether the relationship of asthma to obesity is a real connection ...
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Virus induced airway hyperresponsiveness in guinea pigs is related to a deficiency in nitric oxide
... nitroso-N-acetyl-penicillamine (SNAP, 1 microM) through the lumen of tracheal tubes from infected animals prevented the increase in airway responsiveness to histamine or the cholinoceptor agonist methacholine. The ...
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Cationic protein induced sensory nerve activation: role of substance P in airway hyperresponsiveness and plasma protein extravasation
... extravasation. In vitro, cationic proteins stimulated the release of calcitonin gene-related peptide-like immunoreactivity from perfused slices of the main bronchi. Our results demonstrate that cationic proteins can ...
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An open-label study examining the effect of pharmacological treatment on mannitol- and exercise-induced airway hyperresponsiveness in asthmatic children and adolescents with exercise-induced bronchoconstriction
... Airway hyperresponsiveness (AHR), a characteristic feature of asthma, is an abnormal increase in airflow limitation that follows exposure to a stimulus that would be innocuous in a healthy person ...direct ...
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Prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice
... and airway hyperresponsiveness, defined as an exaggerated contraction of the bronchial smooth muscle (SM) in response to environmental or pharmacological stimuli ...
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Role of C5 in the development of airway inflammation, airway hyperresponsiveness, and ongoing airway response
... of airway inflammation, (b) the maintenance of airway hyperresponsiveness (AHR), and (c) sustainment of an ongoing airway response to allergen ...established airway inflammation did not ...
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Human eosinophil major basic protein induces airway constriction and airway hyperresponsiveness in primates
... responsiveness to inhaled methacholine. Furthermore, MBP and eosinophil peroxidase (EPO) induce a transient bronchoconstriction immediately after instillation that resolves by 1 h postinstillation. In contrast, ...
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Role of Abl in airway hyperresponsiveness and airway remodeling
... region. The abl locus containing a floxed version of the Exon5 of abl and the predicted product of Cre-mediated recombination are also shown. Numbered arrows represent PCR primers. (B) Ethidium bromide-stained agarose ...
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Airway hyperresponsiveness is associated with airway remodeling but not inflammation in aging Cav1-/-mice
... on airway remod- eling after treatment with Cav1 scaffolding domain pep- ...established airway remodeling and AHR ...with airway remodeling is war- ...
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Roles of Bronchopulmonary C-fibers in airway Hyperresponsiveness and airway remodeling induced by house dust mite
... Airway chronic inflammation is an evident character of asthma. Figure 5a showed that HDM exposure sig- nificantly doubled total BALF cells and this response was markedly reduced by PCF degeneration. In con- trast, ...
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