airway responsiveness
Detrimental effects of albuterol on airway responsiveness requires airway inflammation and is independent of β-receptor affinity in murine models of asthma
... Inhalation of allergen is a common trigger of asthma and instigates an immediate release of mediators from mast cells that have the capacity to activate a number of pathways that lead to lung inflammation and AHR [31]. ...
12
Mast cell activation enhances airway responsiveness to methacholine in the mouse
... enhances airway responsiveness to bronchoactive agonists in ...of airway response as the mice were challenged with increasing intravenous doses of methacholine (Mch) or 5- hydroxytryptamine ...
8
Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma
... in airway respon- siveness over the course of the clinical trial that approached those for subjects who were taking inhaled steroids (see Figure 2), suggesting that that IPO13 varia- tion enhances endogenous GC ...
12
Ambient air pollution, lung function, and airway responsiveness in asthmatic children
... Although ambient air pollution has been linked to reduced lung function in healthy children, longitudinal analyses of air pollution effects in asthma are lacking. For instance there are no clinical trials that assessed ...
24
Invasive versus noninvasive measurement of allergic and cholinergic airway responsiveness in mice
... between different magnitudes of AR and reflects the changes with GL and Cdyn during bronchoconstriction at least under the conditions of this study. Moreover, the relation of the cholinergic EF 50 response between ...
10
Toluene diisocyanate increases airway responsiveness to substance P and decreases airway neutral endopeptidase
... the airway hyperresponsiveness caused by toluene diisocyanate (TDI) in guinea ...increase responsiveness to substance P by inhibiting activity of this enzyme, we determined the dose of substance P required ...
6
Prolonged ozone exposure in an allergic airway disease model: Adaptation of airway responsiveness and airway remodeling
... We measured lung function using unrestrained plethys- mography, which in conscious mice represents the extreme of noninvasiveness and is highly convenient; however, it provides respiratory measurements that are so ...
8
Enterovirus D68 infection induces IL-17–dependent neutrophilic airway inflammation and hyperresponsiveness
... induced airway inflammation, expression of cytokines (TNF-a, IL-6, IL-12b, IL-17A, CXCL1, CXCL2, CXCL10, and CCL2), and airway hyperresponsiveness, which were suppressed by anti–IL-17A ...and airway ...
14
A study of agastachis herba on ovalbumin-induced asthma in the mouse
... Korea) was used for the measurement of airway responsiveness. One day after the last OVA challenge through nasal inhalation (day 25), mice were exposed to increasing dose of methacholine using a ultra‑ ...
6
Aldose reductase deficiency in mice protects from ragweed pollen extract (RWE)-induced allergic asthma
... involving airway epithelium, lung fibroblasts and smooth muscles, resident macrophages and dendritic cells and infiltrated leukocytes including eosinophils, neutrophils, and polarized Th2 ...pathology, ...
12
Mechanism of rhinovirus induced changes in airway smooth muscle responsiveness
... altered responsiveness in the proasthmatic atopic sensitized state (34), a phenomenon largely attributed to perturbed receptor/G protein–coupled transmembrane signaling (35, 36), this study addressed the hy- ...
11
A Novel in vivo System to Test Bronchodilators
... While the technique can be adapted for a variety of animal models, the mouse is by far the most commonly used species in asthma research. As described by Bates & Irvin [13], the technique requires that the subject be ...
5
Lung volume dependence of respiratory function in rodent models of diabetes mellitus
... in airway responsiveness [28, 66, 70] or the development of airway hyperre- sponsiveness [16, 17, 71] may be explained by the in- sensitivity of the methods to assess airway function [66], the ...
12
Beta-blockers: friend or foe in asthma?
... was airway responsiveness to inhaled ...histamine responsiveness, lung function, and questionnaires (Mini Asthma Quality Of Life Questionnaire and Asthma Control ...on airway ...
7
Exhaled nitric oxide and airway hyperresponsiveness in workers: a preliminary study in lifeguards
... Forty-eight lifeguards were invited; 44 subjects (32 men, 12 women) agreed to participate (rate of participation: 92%). One subject refused to perform the MBC test while the curves produced by three subjects were ...
9
Original Article Quercetin inhibits airway allergic inflammation through inhibiting the expression of NF-κB activator 1
... market. Airway allergic inflammation is very common in asthma patients, which characterized by excessive eosinophils infiltration, lgE production and enhanced airway resistance due to Th-2 ...the ...
7
Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing
... of airway smooth muscle is the major cause of symptoms in asthma, but the mechanisms that prevent exaggerated contraction are incompletely ...on airway smooth muscle localizes the polyamine catabolizing ...
13
Effects of Corni fructus on ovalbumin-induced airway inflammation and airway hyper-responsiveness in a mouse model of allergic asthma
... Immediately following the assessment of AHR, the mice were killed with an i.p. injection of sodium pentobarbi- tone (100 mg/kg). The trachea was cannulated, and BALF was obtained by washing the airway lumen. ...
12
Antithetic regulation by β adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway β agonist paradox
... on airway contractility are thought to predispose asthmatic patients using β -agonists on a regular basis, and potentially during abrupt withdrawal, to episodes of acute ...
9
Effect of airway acidosis and alkalosis on airway vascular smooth muscle responsiveness to albuterol
... in airway tissue and if the effect is related to the ventilation-associated changes in airway pH as reflected by exhaled breath condensate (EBC) ...albuterol responsiveness associated with re- ...
7