Akt activity
Protein kinase Akt activity in human thyroid tumors
... PI3K/ Akt pathway causes malignant transformation of cells of different origins, including thyroid [3], while inhibiting the cascade with specific inhibitors en- hances the therapeutic effect of anticancer drugs ...
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Withaferin-A suppress AKT induced tumor growth in colorectal cancer cells
... of AKT gene has emerged as a key determinant of the aggressiveness of colorectal cancer (CRC); hence, research has focused on targeting AKT signaling for the treatment of advanced stages of ...
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Heiß, Anika (2010): Die neuroprotektive Wirkung von Opioiden wird durch die Proteinkinase B / AKT vermittelt. Dissertation, LMU München: Tierärztliche Fakultät
... stimulate AKT activity and to evaluate the physiological consequences of this ...in AKT activity, as measured by means of an activation-specific antibody recognizing ...DOR-mediated AKT ...
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Acute modulation of endothelial Akt/PKB activity alters nitric oxide–dependent vasomotor activity in vivo
... that Akt functions as a physiological regulator of NO produc- tion in the vessel ...that Akt is a regulator of eNOS in the intact animal suggests that impairment of endothelial cell function and NO ...
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Differential responses to doxorubicin induced phosphorylation and activation of Akt in human breast cancer cells
... active Akt, or an increased activity of the human epidermal growth factor receptor-2 (HER2)/PI3-K/Akt or Ras/PI3-K/Akt pathway, leads to multidrug or radiation resistance in human breast ...
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Non-thermal plasma induces AKT degradation through turn-on the MUL1 E3 ligase in head and neck cancer
... total AKT levels were decreased by NTP treatment (Figure ...NTP-induced AKT degradation was medicated by MUL1, we evaluated the NTP-induced binding between AKT and MUL1 using a proximity ligation ...
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4 Hydroxynonenal induces apoptosis in human osteoarthritic chondrocytes: the protective role of glutathione S transferase
... examined Akt activity as well as Fas/ CD95 and p53 protein expression in chondrocytes after differ- ent incubation ...of Akt (Figure 6). Total Akt was ...-ICDH activity (Figure 7b), ...
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Akt Inhibitor Akt-IV Blocks Virus Replication through an Akt-Independent Mechanism
... PI3k/Akt activity for efficient ...PI3k activity nor the inhibition of Akt activity decreases VSV gene expression or virus progeny ...the activity of this pathway plays a minimal ...
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Activation of SGK1 in endometrial epithelial cells in response to PI3K/AKT inhibition impairs embryo implantation
... if AKT inhibition enhances SGK1 activity in uterine luminal epithelial cells in vivo , the uterine infundibulum of non-pregnant mice was cannulated and the AKT inhibitor III or V (20 μM), dissolved ...
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Role of Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1α in AKT/PKB-Mediated Inhibition of Hepatitis B Virus Biosynthesis
... and AKT modulate LRH1-dependent HBV tran- scription and replication in human embryonic kidney 293T ...and AKT in the regula- tion of HBV biosynthesis in nonhepatoma cells, viral RNA and DNA synthesis was ...
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Mitogen-Activated Protein Kinase-Interacting Kinase Regulates mTOR/AKT Signaling and Controls the Serine/Arginine-Rich Protein Kinase-Responsive Type 1 Internal Ribosome Entry Site-Mediated Translation and Viral Oncolysis
... of AKT signaling, such as overactive SRPK in the present ...aberrant AKT activity is lethal in cancer cells (34). Although the MNK-AKT-SRPK connection has been the pri- mary focus of the ...
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Zerumbone suppresses IKKα, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells
... [17,18]. Akt, a serine/threonine kinase, mediates many PI3K- regulated biological responses including glucose uptake, protein synthesis, and inhibition of apoptosis ...of Akt, especially constitutively ...
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Zuo Jin Wan reverses P gp mediated drug resistance by inhibiting activation of the PI3K/Akt/NF κB pathway
... and AKT into close proximity ...that Akt phosphorylation can induce drug- resistance in several kinds of tumors, such as ovarian cancer [7], breast cancer [8], and hepatocellular carcin- omas ...
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mTOR: a pharmacologic target for autophagy regulation
... PI3K/ AKT signaling axis. Activated AKT directly phosphorylates and thereby inhibits TSC1/2, a GTPase-activating protein (GAP) for the Ras homolog enriched in brain (Rheb) GTPase ...The AKT-dependent ...
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UNBS5162 inhibits proliferation of human retinoblastoma cells by promoting cell apoptosis
... antihuman Akt, p-Akt, mTOR, p-mTOR (Cell Signaling Technology, Danvers, MA, USA), rabbit antihuman p70, Bcl2, Bax, caspase 3 p17, mouse anti- human cyclin D 1 , and GAPDH (ProteinTech Wuhan, ...
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Phosphorylation of AKT: a Mutational Analysis.
... Oncogenic activity was determined by enumerating foci of transformed cells on CEF ...of AKT-mediated signaling, cultures in which each cell expressed the transfected construct were harvested, and cell ...
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Brittney Allyn Honors Thesis Final Approved.pdf
... of AKT, an intracellular target of the G pathway[6]. AKT phosphorylation is a downstream effect of GPCR signaling and has been shown to be part of a pro-survival pathway[11]; therefore, if decreased GPSM3 ...
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SMARCE1 regulates metastatic potential of breast cancer cells through the HIF1A/PTK2 pathway
... and AKT phosphorylation are downstream events of PTK2 activation in detached cells, we examined the effect of PTK2 inhibition by PF562271 on activation of these ...
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Red Beetroot and Betalains as Cancer Chemopreventative Agents
... suppressive activity have been shown for several xenotransplanted cell ...and Akt was observed, while cyclin B1, cyclin E, cdk2, p-erk, and c-jun activities were ...
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Molecular binary classification of NSCLC: miR-375 is a potential biomarker to differentiate SQCC from ADCC in Indian NSCLC patients
... sensitivity and specificity in the DFA when miR-205 or miR196b is associated with miR-375. The higher accur- acy of miR-375 dragged the outcome towards higher sensitivity and specificity since miR-205 and miR-196b showed ...
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