AKT/mTOR pathway
The PI3K-AKT-mTOR pathway activates recovery from general anesthesia
... PI3K-AKT-mTOR pathway in recovery from general ...PI3K-AKT-mTOR pathway were measured by RT-qPCR and Western ...PI3K-AKT-mTOR pathway, while p-AKT, ...
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The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events
... Accumulating evidence suggests that neurons prone to degeneration in Alzheimer's Disease (AD) exhibit evidence of re-entry into an aberrant mitotic cell cycle. Our laboratory recently demonstrated that, in a genomic ...
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LGR6 promotes the progression of gastric cancer through PI3K/AKT/mTOR pathway
... proapoptotic proteins Bax and Caspase-3 were upregulated by sh-LGR6; the expression of antiapoptotic protein Bcl2 was downregulated by sh-LGR6. This indicated that LGR6 is an antiapoptosis protein which controls the ...
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Triple negative breast cancer: shedding light onto the role of pi3k/akt/mtor pathway
... and mTOR, for targeted treatments in ...PI3K/AKT/mTOR pathway, frequently de-regulated in TNBC, are acquiring a growing interest and several inhibitors are in preclinical development or ...
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PI3K/AKT/mTOR pathway promotes progestin resistance in endometrial cancer cells by inhibition of autophagy
... 3-kinase; aKT, protein kinase B; mTOr, mechanistic target of rapamycin; MTT, 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide; OD, optical density; ctrl, control; h, hours; paKT, ...
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Advanced glycation endproducts trigger autophagy in cadiomyocyte Via RAGE/PI3K/AKT/mTOR pathway
... PI3K/Akt/mTOR pathway via RAGE Western blot assay shows that the AGEs treatment stimu- lated the RAGE expression, however, inhibited the PI3K/ Akt/mTOR pathway in cultured ...
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The expression of the PI3K/AKT/mTOR pathway in gastric cancer and its role in gastric cancer prognosis
... PI3K/ AKT/mTOR ...PI3K/AKT/mTOR pathway inhibitors requires further ...the mTOR inhibitor could activate PI3K/AKT and MAPK pathways through negative feedback, attenuating ...
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Molecularly targeting the PI3K-Akt-mTOR pathway can sensitize cancer cells to radiotherapy and chemotherapy
... Great advances have been also made in the development of molecularly targeted therapies targeting the kinases of the PI3K-Akt-mTOR network. The most common strategy is to inhibit the activities of the ...
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Angelica Sinensis promotes myotube hypertrophy through the PI3K/Akt/mTOR pathway
... China has a long history of using natural products as ergogenic aids to enhance athletic performance. The dried root of Angelica Sinensis (AS) is widely used in traditional Chinese medicine to “nourish one’s vitality and ...
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Antiglioma effects of cytarabine on leptomeningeal metastasis of high-grade glioma by targeting the PI3K/Akt/mTOR pathway
... Abstract: Leptomeningeal metastasis (LM) of high-grade glioma is a highly lethal disease requiring new effective therapeutic measures. For both de novo or relapsed glioma with LM, intrathecal cytarabine chemotherapy is ...
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Alpha-synuclein contributes to malignant progression of human meningioma via the Akt/mTOR pathway
... the Akt/mTOR pathway is involved in the development and progression of meningioma [3, ...of mTOR signaling was reported to impair menin- gioma growth in mouse models ...of Akt ...
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Elevated TRIP13 drives the AKT/mTOR pathway to induce the progression of hepatocellular carcinoma via interacting with ACTN4
... the AKT/mTOR pathway, mass spectrometry (MS) was performed to find potential TRIP13-binding proteins in two HCC cell ...and AKT signaling [12, 13] ...examining ...
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Impact of PI3K/AKT/mTOR pathway activation on the prognosis of patients with head and neck squamous cell carcinomas
... signaling pathway has emerged as the most frequently mutated mitogenic pathway in HNSCC (31%) with multiple actionable targets, representing an excellent opportunity to develop more personalized therapeutic ...
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<p>UNBS5162 and amonafide inhibits tumor progression in human melanoma by the AKT/mTOR pathway</p>
... the AKT/mTOR pathway in melanoma progression remains ...signaling pathway and, thus, inhibit tumor ...the AKT/mTOR pathway, we measured the expression of related genes in ...
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Synaptopodin-2 plays an important role in the metastasis of breast cancer via PI3K/Akt/mTOR pathway
... PI3K/AKT/mTOR pathway plays an important role in cancer cell ...PI3K/ AKT/mTOR signaling pathway, we used Western ...PI3K, AKT, and mTOR (Figure 6A and B), which ...
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Targeting the PI3K/Akt/mTOR Pathway – Beyond Rapalogs
... PI3K pathway due to its influence on cellular metabolism and insulin/glucose regulation, NVP-BKM120 is the only inhibitor in clinical trials that has encountered clinically relevant elevations in plasma ...
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Downregulation of DEPTOR inhibits the proliferation, migration, and survival of osteosarcoma through PI3K/Akt/mTOR pathway
... anti- mTOR monoclonal antibodies (1:1,000; Cell Signaling Technology), rabbit anti-p-mTOR monoclonal antibodies (Ser2488, 1:1,000; Cell Signaling Technology), rabbit anti- eIF-4E-binding protein ...
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Fucosyltransferase VII promotes proliferation via the EGFR/AKT/mTOR pathway in A549 cells
... cell surface and results in cancer metastasis and angiogenesis. However, the molecular biological mechanisms of FUT7 elevation in neoplastic cells are still largely unknown. In this study, we examined the impact of FUT7 ...
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Prucalopride inhibits the glioma cells proliferation and induces autophagy via AKT-mTOR pathway
... was reported that autophagy mediated of suppressing gli- oma cells proliferation via involvement of this signaling [39]. Yu-Chen et al. revealed that autophagy formation was participated in the glioma cells growth ...
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The PI3K/Akt/mTOR pathway in ovarian cancer: therapeutic opportunities and challenges
... Conventional endpoints such as the response assessed according to the Response Evaluation Criteria in Solid Tumors (RECIST) may not be appropriate for evaluating the activity of inhibitors of the PI3K pathway, ...
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