AKT/mTOR signaling
NKAP functions as an oncogene and its expression is induced by CoCl<sub>2</sub> treatment in breast cancer via AKT/mTOR signaling pathway
... we knocked down the expression of NKAP in breast cancer cells. The results showed that NKAP knockdown significantly inhibited the proliferation and clonality of MCF-7 cells and induced its apoptosis through ...
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Original Article The exosome-mediated PI3k/Akt/mTOR signaling pathway in cervical cancer
... PI3k/ Akt/mTOR signaling pathway is associated with the tumorigenesis and malignancy of cervical ...PI3K/ Akt/mTOR signaling pathway are also hot drug design targets, and the ...
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Original Article EBV-LMP1 regulating AKT/mTOR signaling pathway and WWOX in nasopharyngeal carcinoma
... AKT/mTOR signaling pathway was the very important pathway inside the cell in the tumor process, and played an extremely considerable biological functions including proliferation, gr- owth, survival, ...
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Oncogenic NanogP8 expression regulates cell proliferation and migration through the Akt/mTOR signaling pathway in human gastric cancer – SGC-7901cell line
... activated Akt, a key mediator of survival signals, and without affecting total Akt protein ...the AKT/mTOR pathway and further maintained gastric cell ...by Akt/mTOR ...
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SIL1 functions as an oncogene in glioma by AKT/mTOR signaling pathway
... of AKT/ mTOR signaling pathway, including decreased phosphorylation of AKT and mTOR without affect- ing protein expression, as well as decreased expression of the downstream effector ...
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Targeting the PI3K/Akt/mTOR Signaling Pathway: Applications of Nanotechnology
... (9). mTOR is involved in a pathway, known as PI3K/Akt/mTOR signaling pathway that regulates cellular growth behaviors which has the potential to lead to ...that mTOR does its function ...
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Low-frequency ultrasound enhances chemotherapy sensitivity and induces autophagy in PTX-resistant PC-3 cells via the endoplasmic reticulum stress-mediated PI3K/Akt/mTOR signaling pathway
... results demonstrated that the PI3K/AKT/mTOR pathway is inhibited when low-frequency ultrasound treatment was applied to induce ERs. Meanwhile, the combined use of low- frequency ultrasonic and PTX leads to ...
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PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma
... of Akt and mTOR by perfosine and temsirolimus inhibited murine glioblastoma growth no matter PTEN status, a phase I/II trial in recurrent high-grade gliomais ongoing (NCT01051557) [75, ...block Akt ...
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Quantitative Analysis of the Akt/mTOR Signaling Network
... mTORC1 signaling can also be related to cellular ...dysregulated signaling network that apparently extends the range of maximal mTORC1 signaling in our system, whereas Rheb depletion perturbs the ...
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Autophagy Promotes Replication of Influenza A Virus In Vitro
... ABSTRACT Influenza A virus (IAV) infection could induce autophagosome accumu- lation. However, the impact of the autophagy machinery on IAV infection remains controversial. Here, we showed that induction of cellular ...
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Original Article On the in vitro anti-myeloma effect and mechanism of Andrographolide through PI3K/AKT/mTOR and AMPK/mTOR dual signaling pathways
... dual signaling pathways were ...IGF-IR/PI3K/AKT/mTOR signaling pathway, but the administration of IGF-I can reverse the anti-myeloma effect of ...
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Essig, Katharina (2019): A global definition of Roquin-mediated regulation of mRNA expression and translation uncovers its impact on PI3K-mTOR signaling and T cell differentiation. Dissertation, LMU München: Medizinische Fakultät
... cells, mTOR integrates a variety of environmental cues such as growth factors, nutrients, cytokines, co-stimulation, and TCR signals to translate them into distinct T cell fate decisions (Chapman and Chi, 2015; ...
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EEF1D overexpression promotes osteosarcoma cell proliferation by facilitating Akt-mTOR and Akt-bad signaling
... and Akt-Bad are important intracellular signaling pathways, and are known to be closely associ- ated with the progression of tumors, including osteosar- ...as Akt/mammalian target of rapamycin (PI3K/ ...
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Inhibition of PI3K/AKT/mTOR axis disrupts oxidative stress- mediated survival of melanoma cells
... PI3K/AKT/mTOR signaling, which controls cell growth through protein synthesis ...This signaling is often hyperactive in cancer, including melanoma, and targeting this pathway to reduce cancer ...
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Dual Targeting of mTOR Activity with Torin2 Potentiates Anticancer Effects of Cisplatin in Epithelial Ovarian Cancer
... of mTOR has not been fully elucidated in Middle Eastern ...of mTOR complexes (mTORC1 and mTORC2) in a cohort of 156 EOC from Saudi Arabia by immunohistochemistry in a tissue mi- croarray ...both mTOR ...
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Tumor-intrinsic signaling pathways: key roles in the regulation of the immunosuppressive tumor microenvironment
... the AKT-mTOR signaling pathway promotes immune escape by driving the expression of PD-L1, which was confirmed in syngeneic and genetically engineered mouse models of lung cancer where combination ...
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Original Article MiR-29a is down-regulated and inhibits cell proliferation in osteosarcoma: a meta analysis
... In conclusion, we identified 17 differently ex- pressed miRNAs in OS by analyzing public data- bases. Bioinformatics analysis showed differ- entially expressed miRNAs were involved in regulating cell adhesion, cell ...
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PTEN opathies: from biological insights to evidence based precision medicine
... (PI3K) signaling cascade, thereby dampening downstream protein kinase B (PKB/AKT) signaling (7, ...of AKT with subsequent downstream cascades resulting in, ...Notably, AKT represents ...
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N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells
... of mTOR, Phospho-mTOR (Ser2448), Phospho-mTOR (Ser2481), S6K1, Phospho-S6K1 (Thr389), Phospho-S6 Ribosomal Protein (Ser235/236), 4E-BP1, Phospho-4E-BP1 (Ser65), Phospho-Akt (Ser473), ...
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The Effect of 12 Weeks Aerobic Training on Expression of AKT1 and mTORc1 genes in the Left Ventricle of Type 2 Diabetic Rats
... important signaling pathway for left ventricular hypertrophy is the Akt / mTOR pathway, so that measuring the expression of the Akt and mTOR genes together with structural changes in ...
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