Akt/NF-κB
Original Article CXCR4 was involved in andrographolide inhibits atherosclerosis by inactivating the PI3K/AKT/NF-κB signaling pathway
... Abstract: Atherosclerosis is one of the major diseases that seriously impacts human health, which has been con- ceived as a complex process. In this study, we sought to explore the role and the underlying mechanism of ...
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Bovine ephemeral fever virus triggers autophagy enhancing virus replication via upregulation of the Src/JNK/AP1 and PI3K/Akt/NF-κB pathways and suppression of the PI3K/Akt/mTOR pathway
... Bovine ephemeral fever virus (BEFV), an arthro- pod borne virus, is a member of Rhabdoviridae. The bullet-shaped virion consists of a single stranded, neg- ative-sense RNA genome with a lipid envelope and five structural ...
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Aggf1 attenuates neuroinflammation and BBB disruption via PI3K/Akt/NF-κB pathway after subarachnoid hemorrhage in rats
... downstream NF-κB p65, which was associated with upregulation of endothelial junction proteins levels and downregulation of pro-inflammatory cytokines levels in the ...
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Secretory leukocyte protease inhibitor suppresses HPV E6-expressing HNSCC progression by mediating NF-κB and Akt pathways
... tory NF-κB-dependent cytokines and the genes TNF- α, IL-1β, IL-6, IL-8 and c-myc [19, ...of NF-κB signaling pathway promoted the transcription of down- stream ...activated NF-κB ...
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Original Article UHMWPE wear particles and dendritic cells promote osteoclastogenesis of RAW264.7 cells through RANK-activated NF-κB/MAPK/AKT pathways
... p38MAPK, AKT and IKKβ/NF-κB signaling pathways and upregulation of osteo- clastogenic ...and AKT (PF184, SB203580, and Perifosine, respective- ly) substantially inhibited UHMWPE particles and ...
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Original Article Endogenous SARI exerts oncogenic functions in human K562 leukemia cells by targeting the PI3K/Akt/mTOR and NF-κB signaling pathways
... The NF-κB signaling is also one of the well-known pathways that are implicated in cancer progression and angiogenesis ...[29]. NF-κB is an important regulator functions downstream of the ...
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NF κB is activated in response to temozolomide in an AKT dependent manner and confers protection against the growth suppressive effect of the drug
... in AKT- dependent activation of NF-κB in TMZ-treated cells, our results show that this molecular event has a pro- survival function in tumor cells presenting constitutive activation of the MAPK ...
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Tick sialostatins L and L2 differentially influence dendritic cell responses to Borrelia spirochetes
... The effect of sialostatin L2 on the signalling pathways activated by LTA and Borrelia burgdorferi in dendritic cells Induction of proinflammatory mediators by B. burgdor- feri is mediated by multiple signalling pathways ...
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SRC-3 Has a Role in Cancer Other Than as a Nuclear Receptor Coactivator
... Accumulating evidence indicates that the role of SRC-3 in cancer is more than as a nuclear receptor coactivator. Clinical investigations showed that SRC-3 is not only associated with hormone-dependent can- cers. In the ...
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Original Article shRNA-mediated silencing of PKHD1 gene promotes proliferation, migration and invasion of human intrahepatic cholangiocarcinoma HuCCT-1 cells
... [43]. NF-κB, a transcription factor of Akt, is involved in the cell proliferation and apopto- sis induced by multiple growth factors and cyto- kines [40], and NF-κB expression has been ...
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Atractylenolide I modulates ovarian cancer cell mediated immunosuppression by blocking MD 2/TLR4 complex mediated MyD88/NF κB signaling in vitro
... AO-1 could down-regulate expression of IL-6, TGF-β1, IL-17A and VEGF (Fig. 3a–d) but not IL-4 and IL-10 by SKOV3 cells (Fig. 3e, f), and reduce frequencies of Treg cells following exposure of lymphocytes to the superna- ...
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Original Article Differences in gene expression profiles and signaling pathways in rhabdomyolysis-induced acute kidney injury
... Abstract: Purpose: Rhabdomyolysis is a threatening syndrome because it causes the breakdown of skeletal muscle. Muscle destruction leads to the release of myoglobin, intracellular proteins, and electrolytes into the ...
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Decreased SATB1 expression promotes AML cell proliferation through NF-κB activation
... To investigate the mechanisms underlying the enhanced proliferation of HL-60 SATB1-shRNA cells, we analyzed the global gene expression profiles of HL-60 SATB1- shRNA cells and HL-60-CTR cells. Genes were identi- fied as ...
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NF κB: a key role in inflammatory diseases
... the NF- κB/Rel signaling pathway show that NF-κB plays a role in Th1-dependent delayed-type hypersensitivity responses ...(21). NF-κB activation increases expression of the ...
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IKK/NF-κB signaling contributes to glioblastoma stem cell maintenance
... that NF-κB is not highly active in normal brain tissue, we first compared the growth of normal neural stem cells and astrocytes to that of patient-derived GBM explant ...by NF-κB inhibition ...
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IKK/NF κB signaling: balancing life and death – a new approach to cancer therapy
... of NF-kB is promotion of cell survival through induction of target genes, whose products inhibit components of the apoptotic machinery in normal and cancerous ...cells. NF-kB can also prevent programmed ...
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Control of oncogenesis and cancer therapy resistance by the transcription factor NF κB
... of NF- κ B in cells induced to express an oncogenic form of Ras or in some cancer cell lines led to an apoptotic response (27) raised the possibility that inhibitors of NF-κB may function as ...
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Original Article Ruscogenin exerts beneficial effects on monocrotaline-induced pulmonary hypertension by inhibiting NF-κB expression
... the NF-κB signaling path- way ...of NF-κB p65, which indicates that ruscogenin may be used as a potential therapeutic agent for acute lung injury (ALI) or sepsis ...
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NF-κB/RelA-PKM2 mediates inhibition of glycolysis by fenofibrate in glioblastoma cells
... of NF-κB/RelA and also disrupted its association with hypoxia inducible factor1 alpha (HIF1α), which is required for the binding of NF-κB/ RelA to the PKM promoter and PKM2 ...
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The Chinese medicine Sini San inhibits HBx induced migration and invasiveness of human hepatocellular carcinoma cells
... HepG2-HBx cells were treated with 100–800 μg/ml SNS. Nuclear extracts were prepared as described pre- viously [35]. In brief, cells were stimulated, harvested by centrifugation, washed twice with cold PBS, and nu- clear ...
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