Aldehyde dehydrogenase 2 (ALDH2)
Aldehyde Dehydrogenase 2 (ALDH2) Polymorphism and the Risk of Alcoholic Liver Cirrhosis among East Asians: A Meta Analysis
... between ALDH2 polymorphism and the risk of alcoholism and alcohol-induced medical diseases in ...human ALDH2 gene in the pathogenesis of alcohol dependence as well as alcohol-induced medical illnesses in ...
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Mitochondrial aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin
... drial aldehyde dehydrogenase-2 (ALDH2) is the enzyme princi- pally responsible for GTN bioactivation, leading to the release of ...of ALDH2 contributes to GTN tolerance (6). Also, ...
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Inhibition of Aldehyde Dehydrogenase 2 by Oxidative Stress Is Associated with Cardiac Dysfunction in Diabetic Rats
... understood. Aldehyde dehydrogenase 2 (ALDH2) has been considered a key cardioprotective enzyme susceptible to oxidative ...influence ALDH2 activity, and ALDH2 inhibition would ...
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Alcohol Consumption, Aldehyde Dehydrogenase 2 Gene Polymorphisms, and Cardiovascular Health in Korea
... sumption. Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme in alcohol metabolism that degrades acetaldehyde to nontoxic acetic ...the ALDH2 gene, which is commonly polymorphic in East ...
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Aldehyde dehydrogenase 2 inhibits inflammatory response and regulates atherosclerotic plaque
... that aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism, which eliminates ALDH2 activity down to 1%-6%, is a susceptibility gene for coronary ...GFP, ALDH2-overexpression and ...
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Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese
... hyde dehydrogenase 2 (ALDH2) [4]. ALDH2 is an enzyme not only for alcohol metabolism but also for catalyzing the oxidation of an aldehyde that is a lipid peroxidation prod- uct, such as ...
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Aldehyde Dehydrogenase-2 Deficiency Aggravates Cardiac Dysfunction Elicited by Endoplasmic Reticulum Stress Induction
... of ALDH2 after ER stress induction was ...by ALDH2 knock- down (Figure 3E). ALDH2 overexpres- sion and treatment of NAC mitigated p47 phox subunit upregulation induced by tunicamycin (Figure ...by ...
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Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung
... phenotypes. Aldh2*2 Tg mice have smaller body size compared to Aldh2 −/− mice due to reduced muscle and fat ...the Aldh2*2 Tg mice are not caused by the simple lack of Aldh2 ...
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Aldehyde dehydrogenase 2 activation and coevolution of its εPKC-mediated phosphorylation sites
... enhance ALDH2 activity is by post- translational phosphorylation of the ...increases ALDH2 activity in the heart by ~40%, thus protecting the heart from ische- mic injury [31, 32]; phosphorylation of ...
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Effects of ADH1C, ALDH2, and CYP2A6 Polymorphisms on Individual Risk of Tobacco Related Lung Cancer in Male Japanese Smokers
... Vol. 2, ...alcohol dehydrogenase 1C (ADH1C) and aldehyde dehydrogenase 2 (ALDH2)] in 1039 male Japanese smokers (573 lung cancer patients and 466 healthy control subjects) who ...
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The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy
... Lagranha et al. found that adult female rats are pro- tected against ex vivo I/R injury in the presence of E2 as they had smaller infarct size and increased cardiac con- tractility compared to female rats without gonadal ...
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Clinical significance of ALDH2 rs671 polymorphism in esophageal cancer: evidence from 31 case-control studies
... “aldehyde dehydrogenase-2”; “polymorphism”; and “esophagus”; “oesophagus”; and “carcinoma or cancer or neoplasm or tumour or ...the ALDH2 polymorphism and EC risk; 2) the use of a ...
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Original Article Simple and reliable genotyping of ALDH2 rs671 in the patients with acute alcoholism intoxication using Tetra-Primer ARMS PCR
... Abstract: Aldehyde dehydrogenase-2 (ALDH2) is the second enzyme of the major oxidative pathway of alcohol me- tabolism, and is critical for the effective breakdown of alcohol common single ...
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Interactive effects of a common γ-glutamyltransferase 1 variant and low high-density lipoprotein-cholesterol on diabetic macro- and micro-angiopathy
... enzyme; ALDH2: Aldehyde dehydrogenase 2; ALT: Alanine aminotransferase; Apo: Apolipoprotein; ARB: Angiotensin II receptor blocker; AST: Aspartate aminotransferase; AUC: Area under the curve; ...
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Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross tolerance
... mitochondrial aldehyde dehydrogenase (ALDH-2) plays a central role in the process of nitroglycerin (glyceryl trinitrate, GTN) biotransformation in vivo and that its inhibi- tion accounts for ...
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Mechanistic studies on sheep liver aldehyde dehydrogenases : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Chemistry at Massey University, New Zealand
... shown by the fact that the same enzyme may act as an e st erase ( Se c t ion 5 ) , c at alyz ing the hydro lys is of e st ers . The two react ions have been shown to o c cur at the same s it e on the enzyme (Fe ldman and ...
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Comparative genomics of aldehyde dehydrogenase 5a1 (succinate semialdehyde dehydrogenase) and accumulation of gamma-hydroxybutyrate associated with its deficiency
... An inability to metabolise SSA to succinate raises the possibility that neurotoxic aldehydes might accumulate in tissues of affected individuals. Earlier work demonstrated that SSA accumulates in ALDH5A1-deficient mouse ...
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The Aldehyde Dehydrogenase Gene Superfamily Resource Center
... objective is to provide a succinct data analysis for each accession’s sequence and begins with a tabular summary of the accession identifier’s source infor- mation. Using the identifier’s sequence, a graphical ...
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Update on the aldehyde dehydrogenase gene (ALDH) superfamily
... Table 2 summarises these ALDH orthologues, their chromosomal locations and the associated NCBI Entrez gene identification (ID) number for each of the 11 ...‘aldehyde dehydrogenase 1A1-like ...
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Biosynthesis, regulation, and engineering of microbially produced branched biofuels
... Biosynthesis of terminally branched long‑chain fatty acids The biosynthetic pathway of terminally branched LCFAs in B. subtilis is well characterized [47–49] as shown in Fig. 2. This pathway used branched-chain ...
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