Aldose reductase inhibitor
Aldose Reductase Inhibitor Ameliorates Renal Vascular Endothelial Growth Factor Expression in Streptozotocin Induced Diabetic Rats
... Fig. 2. Comparison of glomerular matrix indices (GMI). Although calculated glomerular volumes did not differ among the experimental groups, the glomerular mesangium significantly expanded in untreated diabetic rats ...
7
Administration of an aldose reductase inhibitor induces a decrease of collagen fluorescence in diabetic rats
... an aldose reductase inhibitor known to lower tissue fructose concentration, to experimental diabetic rats led to a decrease in the fluorescence related to ...
5
A defect in sodium dependent amino acid uptake in diabetic rabbit peripheral nerve Correction by an aldose reductase inhibitor or myo inositol administration
... an aldose reductase inhibitor prevented reductions in both nerve myo-inositol content and endoneurial sodium-dependent 2-aminoisobutyric acid ...
10
Glucose induced microvascular functional changes in nondiabetic rats are stereospecific and are prevented by an aldose reductase inhibitor
... 1 is consistent with evidence from numerous studies indicating that vascular functional changes increases in albumin permeation, blood flow, glomerular filtration rate, and urinary album[r] ...
7
Preventive effect of long term aldose reductase inhibition (ponalrestat) on nerve conduction and sural nerve structure in the spontaneously diabetic Bio Breeding rat
... development of functional and structural neuropathy in the insulin-deficient diabetic Bio- Breeding rat (BB-rat), hyperglycemic rats were begun on the aldose reductase inhibitor (ARI) ponalrestat 25 ...
12
INHIBITORY ACTIVITIES OF ALKALOID FROM COCCINIA GRANDIS AGAINST ALDOSE REDUCTASE AND GENERATION OF ADVANCED GLYCATION ENDPRODUCTSHowlader Saurav*, Rajbongshi Lata, Hossain FarhadDOWNLOAD/VIEW
... aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and ...
7
Identification of a rhodanine derivative BML-260 as a potent stimulator of UCP1 expression
... BML-260 belongs to the rhodanine derivative family, and is originally synthesized to inhibit JSP-1 as a potential treatment to inflammatory and proliferative disorders [22]. Rhodanine is a 5-membered heterocyclic organic ...
14
Effects of glucose on sorbitol pathway activation, cellular redox, and metabolism of myo inositol, phosphoinositide, and diacylglycerol in cultured human retinal pigment epithelial cells
... high aldose reductase expressing retinal pigment epithelial cells, glucose-induced, aldose reductase inhibitor-sensitive CDP- diglyceride accumulation and inhibition of ...
8
The linked roles of nitric oxide, aldose reductase and, (Na+,K+) ATPase in the slowing of nerve conduction in the streptozotocin diabetic rat
... competitive inhibitor of nitric oxide synthase reversed the increased nerve conduction velocity afforded by aldose reductase inhibitor treatment in the acutely diabetic rat without affecting ...
8
Polyol pathway and modulation of ischemia-reperfusion injury in Type 2 diabetic BBZ rat hearts
... LVDP changes in untreated 48 weeks diabetic rat hearts were also impaired under baseline and reperfusion (Fig- ure 4D, E respectively) in comparison with non-diabetic rat hearts. Treatment of the diabetic rat hearts with ...
11
New insights into the catalytic mechanism of aldose reductase : a QM/MM study
... Aldose reductase (AR) (EC ...1,2 Aldose reductase has been identified as the first enzyme involved in the polyol pathway of glucose metabolism that converts glucose to fructose via ...
11
Identification, characterization of two NADPH-dependent erythrose reductases in the yeast Yarrowia lipolytica and improvement of erythritol productivity using metabolic engineering
... erythrose reductase(s). In the earlier report, an erythrose reductase gene (YALI0F18590g) from erythritol-producing yeast ...erythrose reductase gene(s) might exist in the genome of ...erythrose ...
12
Aldose reductase functions as a detoxification system for lipid peroxidation products in vasculitis
... Giant cell arteritis (GCA) is a systemic vasculitis preferentially affecting large and medium- sized arteries. Inflammatory infiltrates in the arterial wall induce luminal occlusion with subsequent ischemia and ...
8
Alcohol Extract of Wattakaka volubilis (L.F) Stapf Root Inhibits Aldose Reductase to Prevent Diabetes Associated Cataract Formation in Rats
... AR: Aldose Reductase; ARIs: Aldose Reductase Inhib- itors; b.w: Body weight; CPCSEA: Committee for the Purpose of Control on Experiments in Animals; d: Day; dL: Deciliter; DM: Diabetes ...
7
Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice
... encoding aldose reductase (AR), an enzyme that mediates the generation of toxic products from glucose, is expressed at low levels in murine compared with human ...
11
Inhibitory activity of leaf extract of Tinospora cordifolia and magnoflorine on aldose reductase for control of diabetes
... Primary compounds present in the active fraction of T. cordifolia Alkaloidal fraction of Tinospora cordifolia leaves were isolated by fractionation through column and TLC and characterized through high-performance liquid ...
7
Sorbitol, osmoregulation, and the complications of diabetes
... In view of the evidence that aldose reductase and sorbitol help regulate the volume and intracellular milieu of renal medullary cells after changes in external osmolality, it is worth co[r] ...
7
Journal of Applied Pharmaceutical Science
... Chlorogenic acid (5-O-caffeoylquinic acid), a phenolic compound found ubiquitously in plants, is an antioxidant and metal chelator (Kono et al., 1998). It has been reported that the intake of this compound in diabetic ...
8
EVALUATION OF α AMYLASE, α GLUCOSIDASE AND ALDOSE REDUCTASE INHIBITORS IN ETHYL ACETATE EXTRACTS OF ENDOPHYTIC FUNGI ISOLATED FROM ANTI DIABETIC MEDICINAL PLANTS
... Preparation of rat lens aldose reductase (ALR2) Crude aldose reductase was prepared from 2-3 month old WNIN male rate lens by dissecting its eye balls. The dissected lenses were homogenized ...
8
Glucose and collagen regulate human platelet activity through aldose reductase induction of thromboxane
... Western blotting. Platelets were homogenized in the lysis buffer (25 mmol/l Tris HCl, pH 7.6, 150 mmol/l NaCl, 1% NP-40, 1% sodium deoxycholate, 0.1% SDS), with the addition of 0.1% protease inhibitor and 0.1% ...
16