Alpha-Actinin
Alpha-actinin-3 R577X Polymorphism Profile of Turkish Professional Hip-Hop and Latin Dancers
... Actins are small globular filaments functioning in cell processes like muscle contraction, and stabilized to the sarcomeric Z- discs by actin binding proteins (actinins). One of the important gene coding for actin ...
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The role of alpha-actinin-4 in human kidney disease
... Mutations in the Alpha-actinin-4 gene (ACTN4) cause a rare form of familial focal segmental glomerulosclerosis in humans. Individuals with kidney disease-associated ACTN4 mutations tend to have mild to ...
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Alpha-Actinin-3 (ACTN3) R/X Gene Polymorphism and Physical Performance of Multi-Ethnic Malaysian Population
... The alpha-actinin-3 (ACTN3) R/X gene polymorphism (rs1815739) is one of the genetic variants that has been most widely studied for human physical performance ...
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Relationship between anti dsDNA, anti nucleosome and anti alpha actinin antibodies and markers of renal disease in patients with lupus nephritis: a prospective longitudinal study
... The data were analysed in GraphPad Prism (GraphPad Soft- ware Inc., San Diego, CA, USA) and using the 'xt' commands for longitudinal data in Stata 9.2 (StataCorp LP, College Sta- tion, TX, USA). The aim of the analysis ...
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Actin-binding protein alpha-actinin 4 (ACTN4) is a transcriptional co-activator of RelA/p65 sub-unit of NF-kB.
... Thus, we speculate that the nuclear role of ACTN4 in regulation of transcription factor activity differs from its function in the cytoplasm and does not depend on the actin binding... MA[r] ...
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alpha-Actinin interacts with rapsyn in agrin-stimulated AChR clustering
... Anti-α-actinin antibody was from Upstate (Charlottes- ville, VA); and fluorescein-conjugated cholera toxin B sub- unit (FITC-CTX) was from Sigma (St. Louis, MO). Rabbit anti-rapsyn antibody was generated using ...
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Alpha actinin binding antibodies in relation to systemic lupus erythematosus and lupus nephritis
... serve as a diagnostically valuable parameter for SLE. How- ever, in a randomised ANA-positive group, the anti-α-actinin Ab was more prevalent in non-SLE patients than in SLE patients. The 20% prevalence of these ...
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Alpha-actinin binding kinetics modulate cellular dynamics and force generation
... Contributed by Martin R. Pollak, March 25, 2015 (sent for review January 14, 2015) The actin cytoskeleton is a key element of cell structure and movement whose properties are determined by a host of accessory proteins. ...
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alpha-Actinin Immunofluorescent Localization.pdf
... When the ol-actinin and the tropomyosin antibodies are applied sequentially to cells in appropriate dilutions, they produce a staining pattern without any stria- t[r] ...
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Frequency analysis of the ACTN3 gene polymorphism in children with isolated or combined orthodontic pathology with allergic rhinitis
... the alpha-actinin-3 ...coding alpha-actinin-3 protein synthesis in children with distal bite may indicate the role of muscle strength and their pressure on the dentition in the process of ...
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Original Article Expression patterns of podocyte-associated mRNAs in patients with proliferative or non-proliferative glomerulopathies
... and alpha-actinin-4 were measured in the kidney tissue and urinary cells by real-time polymerase chain ...and alpha-actinin-4 compared with baseline ...group, alpha-actinin-4 ...
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Multipotency and cardiomyogenic potential of human adipose-derived stem cells from epicardium, pericardium, and omentum
... confirm this observation, revealing the stem cell specific phenotype of the BJ fibroblasts and their osteogenic po- tential. Thus, MSCs and fibroblasts are hypothesized to be just different states in a single cellular ...
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Coexistence of congenital left ventricular aneurysm and prominent left ventricular trabeculation in a patient with LDB3 mutation: a case report
... ACTA1: Alpha-actin 1; ACTN2: Alpha-actinin-2; ANA: Antinuclear antibody; ARVC: Arrhythmogenic right ventricular cardiomyopathy; ASO: Antistreptolysin O; AST: Aspartate aminotransferase; C: ...
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Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including α-actinin 4
... To identify O-GlcNAcylated proteins, we employed two-dimensional electrophoresis and immunoblotting using the CTD110.6 anti-O-GlcNAc antibody. Total proteins of diabetic GK rat kidney or nondiabetic Wistar rat kidney ...
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Analysis of the proteome of human airway epithelial secretions
... Among the 55 proteins that were identified in the high molecular weight fraction of hAECS from in vitro cul- tures of primary NHBE cells collected under physiologi- cal conditions, 43 (78.2%) were unique to this study ...
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Molecular interactions of the mammalian intermediate filament protein synemin with cytoskeletal proteins present in adhesion sites
... al., 2006). Studies by Mizuno et al. (2001) demonstrated that the human synemin rod domain binds to α-dystrobrevin, a component of the dystrophin-associated protein complex that interacts directly with dystrophin (Mizuno ...
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Original Article Differentiation of brown adipose-derived stem cells into cardiomyocyte-like cells is regulated by a combination of low 5-azacytidine concentration and bone morphogenetic protein 4
... α-sarcomeric actinin (dilution 1:400, sigma), cTnI (dilution 1:400, Abcam, Britain), SERCA2α (dilution 1:200, Santa Cruz Biote- chnology, USA), and Cx43 (dilution 1:300, Sigma) at 4°C for 24 ...
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Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin
... Focal segmental glomerulosclerosis (FSGS) is the most common primary glomerular diagnosis resulting in end-stage renal disease. Defects in several podocyte proteins have been implicated in the etiology of FSGS, including ...
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Structural and biochemical characterisation of utrophin and dystrophin spectrin repeat domains : submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Biochemistry, Massey University, Palmerston North, NZ
... Despite multiple structures of spectrin repeats in the Protein Data Bank from α-actinin, spectrin and plectin these are the first structures determined for any of the spectrin repeats fr[r] ...
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Synaptopodin regulates the actin bundling activity of α actinin in an isoform specific manner
... mouse kidney, Synpo-long colocalized with α-actinin-4 in podocytes (Figure 4A). Similarly, in differentiated cultured podocytes, synap- topodin colocalized with α-actinin in a dotted pattern along stress ...
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