alpha-ketoglutarate
Effects of alpha-ketoglutarate on lifespan and functional aging of Drosophila melanogaster flies
... an alpha-ketoglutarate-supplemented diet on lifespan and functional senescence were evaluated in the Canton S strain of Drosophila ...dietary alpha- ketoglutarate (AKG) are dose- and ...
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Effect of Alpha-Ketoglutarate on Growth and Metabolism of Cells Cultured on Three-Dimensional Cryogel Matrix
... Alpha- ketoglutarate (α-KG) is a well-known intermediate of Kreb’s cycle and thus one of the important candidates in the role of cellular metabolism. The aim was to investigate the effect of α-KG on the ...
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Effects of combined maternal administration with alpha-ketoglutarate (AKG) and β-hydroxy-β-methylbutyrate (HMB) on prenatal programming of skeletal properties in the offspring
... with alpha-ketoglutarate and β -hydroxy- β -methylbutyrate induces additive long-term effects on skeletal system properties in the ...of alpha-ketoglutarate and ...
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Inactivation of beef brain alpha ketoglutarate dehydrogenase complex by valproic acid and valproic acid metabolites Possible mechanism of anticonvulsant and toxic actions
... The anticonvulsant valproic acid (VPA, 2-n-propylpentanoic acid) causes inhibition of the citric acid cycle and elevations of central nervous system (CNS) gamma-aminobutyric acid (GABA) levels, which correlates with ...
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Acute L-arginine alpha ketoglutarate supplementation fails to improve muscular performance in resistance trained and untrained men
... acute ingestion of AAKG. This may suggest that a specific loading period may be necessary for the prospective ergo- genic effects of arginine-based supplements to be realized. Specifically, Santos et al. [21] observed a ...
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The effect of Nigella Sativa extract on Alpha-ketoglutarate activity and histopathologic changes on Rat liver induced by Monosodium glutamate
... into alpha KGDH in the body leads to increase alpha KGDH ...in alpha KGDH could pro- duce reactive oxygen species that lead to oxidative stress “imbalances in the equilibrium between pro-oxi- ...
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Mutations in human lipoyltransferase gene LIPT1cause a Leigh disease with secondary deficiency for pyruvate and alpha-ketoglutarate dehydrogenase
... phenotype of the diseases that involve lipoic acid de novo biosynthesis show numerous additional dysfunc- tions that are related to the [Fe-S] cluster pathway. These additional dysfunctions [5,19] affect succinate ...
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A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process
... α- ketoglutarate and pyruvate were too low to measure in these experiments, glutamine (a proxy for KGDH sub- strate) showed scaled intensity levels 25% higher in treated cells, corroborating KGDH ...
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Glutaminase 1 regulates the release of extracellular vesicles during neuroinflammation through key metabolic intermediate alpha-ketoglutarate
... Glutamine is the most abundant amino acid in the plasma, and the metabolism of glutamine involves hy- drolysis to glutamate by mitochondrial enzyme glutamin- ase 1 (GLS1). Subsequently, glutamate can be excreted or can ...
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Diversity of flux distribution in central carbon metabolism of S. cerevisiae strains from diverse environments
... We also found correlations between blocks that had two main origins. In first case, these correlations were compulsory due to the model structure. For example, there was an expected negative correlation between the ...
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Evidence that 2-hydroxyglutarate is not readily metabolized in colorectal carcinoma cells
... C-labeled alpha-ketoglutarate, which would then be metabolized by other pathways such as the TCA ...as alpha-ketoglutarate, the findings were consistent with the metabolomic data described ...
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Nanobiomechanical Properties of Microtubules
... work, alpha-alpha, alpha-beta, beta- alpha and beta-beta dimers have been studied to find their structures using HADDOCK (High ambiguity driven docking approach) ...
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Mitochondrial Alteration: A Major Player in Carcinogenesis
... For example: IDH mutations causes the formation of oncometabolite 2-hydroxyglutarate (2-HG) instead of α-ketoglutarate (αKG). The PI3K, mTOR, p53, MYC and HIF1 parti[r] ...
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Glutamine Metabolism Is Essential for Human Cytomegalovirus Infection
... We show that during the course of HCMV infection, the level of glutamine consumption increases, and the infected cells become dependent upon glutamine for ATP production and viral production. HCMV begins to induce the ...
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Analysis of the proteome of human airway epithelial secretions
... Among the 55 proteins that were identified in the high molecular weight fraction of hAECS from in vitro cul- tures of primary NHBE cells collected under physiologi- cal conditions, 43 (78.2%) were unique to this study ...
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α Ketoglutarate regulates acid base balance through an intrarenal paracrine mechanism
... α-Ketoglutarate (αKG) is an intermediate of the citric acid (TCA) cycle, an important anaplerotic substrate and a cofactor in a variety of enzymatic reactions. In addition to its direct effects on meta- bolic ...
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Monosodium glutamate-induced oxidative kidney damage and possible mechanisms: a mini-review
... α -Ketoglutarate dehydrogenase: an ROS generator A recent study has shown that increased activity of α- KGDH is related to the glutamate-stimulated ROS production in rat kidneys [5]. According to this study, ...
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Exploring d-xylose oxidation in Saccharomyces cerevisiae through the Weimberg pathway
... None of the recombinant strains designed in the pre- sent study could sustain growth on d-xylose alone and only d-xylonate formation was detected. Although all genes were transcribed, it remained unclear whether the ...
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Original Article Inhibitory effects of dimethyl α-ketoglutarate in hepatic stellate cell activation
... Whole-cell lysates were made in chilled RIPA buffer (Beyotime, China) of 50 mM Tris (pH 7.4), 150 mM NaCl, 1% sodium deoxycholate, 1% Triton X-100, 0.1% SDS and protease inhibitor cocktail with 1 mM phenylmethanesulfonyl ...
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Glutamate and asparagine cataplerosis underlie glutamine addiction in melanoma
... The above results pointed to the importance of two input/output reactions on either side of the TCA cycle for glutamine metabolism. The conversion of glutamate to α-ketoglutarate is an anaplerotic reaction, and, ...
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