alpha v beta 3 integrin
Glioblastoma expression of vitronectin and the alpha v beta 3 integrin Adhesion mechanism for transformed glial cells
... The alpha v beta 3 integrin was the only vitronectin receptor identified in glioblastoma tumors in situ, and was also not expressed on low grade astroglial-derived tumors, ...
10
Involvement of ROS alpha v beta 3 integrin FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia
... dimeric integrin molecules mediate various complex processes including angiogenesis in a cell type- and context-dependent manner ...β3 integrin is mainly associated with tumor metastasis, and the αvβ3 ...
11
Alpha-enolase (ENO1) controls alpha v/beta 3 integrin expression and regulates pancreatic cancer adhesion, invasion, and metastasis
... Annexin V; APC: Allophycocyanin; ARPC4: Actin related protein 2/3 complex subunit 4 isoform a; ATP: Adenosine triphosphate; BCAR1: Breast cancer anti-estrogen resistance 1; CAPZA2: Capping protein actin ...
13
Upregulation of integrins alpha v beta 3 and alpha v beta 5 on human monocytes and T lymphocytes facilitates adenovirus-mediated gene delivery.
... a v b 3 and a v b 5 can be differentially induced on human monocytes by the hematopoietic growth factors granulocyte-macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating ...
7
Overexpression of platelet type 12 lipoxygenase promotes tumor cell survival by enhancing alpha(v)beta(3) and alpha(v)beta(5) integrin expression
... The ability of tumors to invade beyond hemostatic boundaries and form metastatic colonies requires the complex interplay of various cell surface-associated components regulating the proteolytic disruption of the ECM and ...
10
Integrin α<sub>v</sub>β<sub>3</sub>-targeted gold nanoshells augment tumor vasculature-specific imaging and therapy
... cancers, integrin α v β 3 is a crucial cell adhesion and signaling molecule that promotes the proliferation, survival, drug-resistant properties, and metastatic potential of cancer ...of ...
11
Human melanoma cells derived from lymphatic metastases use integrin alpha v beta 3 to adhere to lymph node vitronectin
... to integrin alpha v beta ...of alpha v beta 3 on the metastatic cells as compared to the parent ...the alpha v beta 3 receptor plays a ...
9
A concise review of magnetic resonance molecular imaging of tumor angiogenesis by targeting integrin αvβ3 with magnetic probes
... for integrin α v β 3 was dem- onstrated by incubating proliferating human umbilical vein endothelial cells (HUVECs, integrin α v β 3-positive) with rHDL-RGD or control (scramble ...
11
Expression of alpha v beta 5 integrin is necessary for efficient adenovirus-mediated gene transfer in the human airway.
... cells were fixed with 0.5% glutaraldehyde in phosphate-buffered saline (PBS; pH 7.4) and stained in 5-bromo-4-chloro-3-indolyl- b - D -galactopyranoside (X-Gal) solution. Infectivity was calculated as the ...
12
α<sub>v</sub>β<sub>3</sub> integrin-targeted micellar mertansine prodrug effectively inhibits triple-negative breast cancer in vivo
... 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT; Sigma-Aldrich Co., St Louis, MO, USA), 4 ′ 6-diamidino-2-phenylindole dihydrochloride (DAPI; Sigma- Aldrich Co.), 1,1 ′ -dioctadecyltetramethyl ...
9
Involvement of integrin alpha V gene expression in human melanoma tumorigenicity
... of alpha v integrins on the tumorigenicity of human ...lack alpha v gene expression and thus fail to express integrin alpha v beta 3 (M21-L ...identical ...
6
Vitronectin enhances internalization of crocidolite asbestos by rabbit pleural mesothelial cells via the integrin alpha v beta 5
... Because incubation of asbestos fibers with serum increases their association with cells, we asked whether a protein coat on asbestos increased internalization of fibers via specific cellular receptors. Coating ...
16
Insulin like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo
... for a total of 7 to 9 d, at which time the embryos were killed. Tumors that formed at the primary site were excised, trimmed free of sur- rounding CAM tissue, and weights were determined. Pulmonary me- tastasis was ...
10
Nanotetrac targets integrin αvβ3 on tumor cells to disorder cell defense pathways and block angiogenesis
... α v β 3, as antibody to the integrin may, but selectively manipulates the functions of the integrin, so that apoptosis is fostered and antiapoptosis defenses are ...
6
Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin
... In this report we provide evidence that integrin av/33 is highly expressed on angiogenic vessels associated with biopsies of malignant human breast carcinoma, suggesting that integrin av[r] ...
9
Integrin Alpha V Beta 3 Matrix Metalloproteinase 2 (MMP 2), Cross Talk
... breast cancer cases of different stages from the institutional hospital catchment area. Patients were offered treatment according to the stage of the disease, either surgery followed by chemotherapy and ± Radiotherapy or ...
10
Exploration of peptide T7 and its derivative as integrin αvβ3-targeted imaging agents
... α v β 3 expression on the surface of eleven different cell lines was performed by FCM using antibody (ab93513; Abcam), which was monocloned based on the RGD recognizing mode (as per Abcam’s product ...
9
Identification of surface proteins mediating adherence of CD11/CD18 deficient lymphoblastoid cells to cultured human endothelium
... the alpha 4 polypeptide (CD49d) and the beta 1 polypeptide (CD29) of the lymphocyte VLA-4 integrin receptor (CD49d/CD29), and to vascular cell adhesion molecule-1 (VCAM-1) on the endothelial cell ...
5
Clinicopathological and prognostic values of fibronectin and integrin αvβ3 expression in primary osteosarcoma
... α v β 3 in osteosarcoma and clinicopathological characteristics The osteosarcoma patients’ clinicopathological charac- teristics are summarized in the Additional file 1: Table ...(Table 3) and ...
12
Estimates for the commutators of operator \(V^{\alpha }\nabla ( \Delta +V)^{ \beta }\)
... operator have appeared (see [1–5]). In recent years, some researchers have studied the boundedness of the commutators generated by the operators associated with L and the BMO type space (see [6–9]). In this paper, we ...
18