alveolar epithelial type II cell
Alveolar epithelial type II cell: defender of the alveolus revisited
... AE2 cell hyperplasia induced in rats in vivo by instillation of recombinant KGF protein or by transfer of the gene encoding KGF did not result in fibrosis ...AE2 cell apoptosis was shown to result in ...
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Double impact of cigarette smoke and mechanical ventilation on the alveolar epithelial type II cell
... BAL cell counts were significantly ele- ...of alveolar epithelial inflamma- tion with the combined intervention compared with either intervention ...in alveolar epithelial ...the ...
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Human alveolar epithelial cells type II are capable of TGFβ-dependent epithelial-mesenchymal-transition and collagen-synthesis
... Cultivated hAECII expressed on a baseline level E-Cadherin, but also Vimentin and at a low level, Collagen I after 48 h of incubation (Fig. 4a). Addition of TGFβ resulted in a dramatic increase of Vimentin expression as ...
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Fibronectin mediates adherence of rat alveolar type II epithelial cells via the fibroblastic cell attachment domain
... mediated type II cell adherence, 10 micrograms/ml gave maximal adherence, and 4 micrograms/ml gave 50% maximal ...fibronectin cell-attachment domain blocked adherence ...
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Endothelial-monocyte activating polypeptide II disrupts alveolar epithelial type II to type I cell transdifferentiation
... total cell number was calcu- lated using DAPI (nuclear) counting in the same field and the positive TUNEL or Ki67 cells were reported as percent of cells ...
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Phenotypic alterations in type II alveolar epithelial cells in CD4+ T cell mediated lung inflammation
... AEC II in inflamma- tory pneumonitis involving the expression and secretion of soluble mediators that may affect other immune cells with regulatory features which may amplify, or interfere with, inflammatory ...
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Culture of human alveolar epithelial type II cells by sprouting
... lung alveolar epithelium comprises two types of specialized epithelial cells, the alveolar epithelial type I cells (AT1), that cover approximately 93% of the alveolar surface ...
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PlGF mediates neutrophil elastase-induced airway epithelial cell apoptosis and emphysema
... Apoptosis of LE cells results in the loss of lung paren- chyma and is a potential pathogenic mechanism for em- physema and COPD [21]. Placenta growth factor (PlGF) induces apoptosis of type II ...
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Clara cell adhesion and migration to extracellular matrix
... tial cell density by proliferation and redistribution of dif- ferentiated epithelial cells over the provisional matrix ...of epithelial cells to differ- ent matrix components is of interest, as the ...
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Original Article Hyperbaric oxygen treatment reduced the lung injury of type II decompression sickness
... that type II alveolar epithelial cells secreted more surfactants in order to compensate for and maintain the stability of the respiration mem- ...in type II alveo- lar ...
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Regeneration of the lung: Lung stem cells and the development of lung mimicking devices
... AT- II cells, indicating that other cell sources also contribute to re-alveolarization ...progenitor cell populations and activating the plasticity or fate of dif- ferentiated lung ...specific ...
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Mac-1 deficiency induces respiratory failure by affecting type I alveolar epithelial cells.
... I alveolar epithelial cells cover more than 95% of the alveolar surface, and are vulnerable to various ...from type II alveolar cells, the involvement of which in lung injury has ...
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Alveolar Type II Epithelial Cells Contribute to the Anti Influenza A Virus Response in the Lung by Integrating Pathogen and Microenvironment Derived Signals
... immune cell recruitment to the respiratory tract are induced by day 3 postinfection (19), and we analyzed transcriptional reg- ulation in AECII and lung tissue at this time ...
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Mechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP)
... adenocarcinoma epithelial cell line; AM: alveolar macrophages; AO: adverse outcome; AOP: adverse outcome pathway; ATII: primary human alveolar type-II epithelial cells; ...
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Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis
... in alveolar macrophages and lung tissue homogenate but not in type II alveolar epithelial cells both under baseline conditions and in response to bleomycin was noted, suggesting that ...
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Conditional overexpression of TGFβ1 promotes pulmonary inflammation, apoptosis and mortality via TGFβR2 in the developing mouse lung
... as cell death in A549 cells upon hyperoxia exposure in a dose-dependent manner ...primary alveolar epithelial Type II cells led to increased sensitivity to TGFβ-induced apoptosis ...
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Interleukin 10 Down Regulates Cathepsin B Expression in Fetal Rat Alveolar Type II Cells Exposed to Hyperoxia
... fetal type II cell death from the early stage of sublethal and lethal hyperoxia, and cathepsin B-de- pendent cell death may be prevented by IL-10 in fetal alveo- lar type II ...
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GABA receptor ameliorates ventilator induced lung injury in rats by improving alveolar fluid clearance
... causes epithelial damage, oxidative stress, surfactant inactivation, and pul- monary edema ...clear alveolar fluid in rats after injurious mechanical venti- lation ...angiotensin II, and silve- stat, ...
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Epithelial Sodium Channels in Pulmonary Epithelial Progenitor and Stem Cells
... (ENaC), a critical pathway for transapical salt and fluid transport, are expressed in lung epithelial progenitors, including club and ATII cells. Since ENaC activity and expression are development- and ...
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Case Report Primary pleomorphic adenoma of the lung with positive staining of TTF-1: a case report and review of literature
... and squamous cells. In the component of gl- andular or tubular structure, the tumor cells arranged as two layers. The inner layer was lined by cuboidal or low columnar epithelial cells with eosinophilic cytoplasm. ...
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