Aminopeptidase N
Phosphonic analogues of phenylglycine as inhibitors of aminopeptidases: Comparison of porcine aminopeptidase N, bovine leucine aminopeptidase and aminopeptidase from barley seeds
... Abstract: Inhibitory activity of 14 phosphonic analogues of phenylglycine, substituted in aromatic ring by fluorine and chlorine, was determined towards porcine aminopeptidase N. The obtained data served as ...
11
Molecular Determinants of Species Specificity in the Coronavirus Receptor Aminopeptidase N (CD13): Influence of N-Linked Glycosylation
... Aminopeptidase N (APN), a 150-kDa metalloprotease also called CD13, serves as a receptor for serologically related coronaviruses of humans (human coronavirus 229E [HCoV-229E]), pigs, and ...an ...
12
Dipeptidyl peptidase IV, aminopeptidase N and DPIV/APN-like proteases in cerebral ischemia
... and aminopeptidase N were up-regulated ipsilaterally from 6 h to 7 days post ischemia, whereas dipeptidyl peptidase 9 and cytosolic alanyl-aminopeptidase were transiently down-regulated at day ...and ...
15
Original Article Relation between the expression of aminopeptidase N(APN)/CD13 and the clinical significance in osteosarcomas
... Received May 10, 2016; Accepted July 26, 2016; Epub November 15, 2016; Published November 30, 2016 Abstract: Aminopeptidase N(APN)/CD13 is highly expressed in many malignant cells. This study aimed to ...
7
Binding determinants in the interplay between porcine aminopeptidase N and enterotoxigenic Escherichia coli F4 fimbriae
... Porcine aminopeptidase N is a receptor for TGEV, the protein interacted with viral spike (S) glycoprotein and AAs 717–813 are essential for TGEV infectivity ...an N-glycosylation sequon between AAs ...
11
Feline aminopeptidase N serves as a receptor for feline, canine, porcine, and human coronaviruses in serogroup I.
... Two members of coronavirus serogroup I, human respiratory coronavirus HCV-229E and porcine trans- missible gastroenteritis virus (TGEV), use aminopeptidase N (APN) as their cellular receptors. These viruses ...
6
In Vitro Evidence Supports Membrane Alanyl Aminopeptidase N as a Receptor for a Plant Virus in the Pea Aphid Vector
... alanyl aminopeptidase N (APN) as a receptor for pea enation mosaic virus (PEMV) coat protein (CP) in the gut of the pea aphid, Acyrthosiphon pisum, using a far-Western blot ...
10
Porcine Deltacoronavirus Engages the Transmissible Gastroenteritis Virus Functional Receptor Porcine Aminopeptidase N for Infectious Cellular Entry
... porcine aminopeptidase N (pAPN) acts as a cross-genus CoV func- tional receptor for both enteropathogenic porcine deltacoronovirus (PDCoV) and alphacoronovirus (AlphaCoV) (transmissible gastroenteritis ...
13
Original Article Luteolin inhibit the cell growth by influencing aminopeptidase N in HepG2
... [1]; Aminopeptidase N (APN) plays an essential part in physiological regulation and signal transmission between tissues and cells in the body, with its function and effects varying depending on its ...
7
Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N
... hydrophobic segment near the amino terminus. Amino-terminal protein sequence analysis of CD13 molecules indicated that the hydrophobic segment is not cleaved, but rather serves as both a signal for membrane insertion and ...
10
Mutational Analysis of Aminopeptidase N, a Receptor for Several Group 1 Coronaviruses, Identifies Key Determinants of Viral Host Range
... use aminopeptidase N (APN) of their natural host and feline APN (fAPN) as ...an N-glycosylation sequon present between aa 288 to 290 in murine ...
13
Involvement of Aminopeptidase N (CD13) in Infection of Human Neural Cells by Human Coronavirus 229E
... Attachment to a cell surface receptor can be a major determinant of virus tropism. Previous studies have shown that human respiratory coronavirus HCV-229E uses human aminopeptidase N (hAPN [CD13]) as its ...
9
Feline aminopeptidase N is not a functional receptor for avian infectious bronchitis virus
... canine aminopeptidase N (APN) as functional receptors during virus entry ...recognize N-acetyl-9-O- acetylneuraminic acid as a functional receptor ...
10
Research of inhibition mechanism of morin on tumor cells aminopeptidase N
... Aminopeptidase N catalytic substrate (L-leucine-p-nitroanilide phthalate) produce Para- nitroaniline which has UV absorption at 405 nm,and concentration of Para- nitroaniline is positively correlated with ...
7
peptide induces a caspase-independent, Ca 2+ -dependent death in human leukemic myeloid cells by targeting surface aminopeptidase N/CD13
... Anti-actin (C4, mIgG1) was from ICN Biomedicals (Aurora, OH, USA). The secondary, horseradish peroxidase (HRP)-conjugated antibodies were bought from Dako Cytomation (Glostrup, Denmark). ZVAD-fmk (a general caspase ...
23
Determinants essential for the transmissible gastroenteritis virus-receptor interaction reside within a domain of aminopeptidase-N that is distinct from the enzymatic site.
... 5216-5224 0022-538X/94/$04.00+0 Copyright © 1994, American Society for Microbiology Determinants Essential for the Transmissible Gastroenteritis Virus-Receptor Interaction Reside within [r] ...
9
CD13 (human aminopeptidase N) mediates human cytomegalovirus infection.
... To further characterize the kinetics of HCMV antigen expression and to determine whether infected mouse cells expressing human CD13 could produce and release infectious virus, AD169- or [r] ...
10
Porcine aminopeptidase N binds to F4+ enterotoxigenic Escherichia coli fimbriae
... The addition of both APN polyclonal anti- serum and an anti-F4 fimbriae monoclonal antibody to IPEC-J2 cells also reduced ETEC adhesion (Figure 3 B).. Discussion.[r] ...
7
Interspecies differences in membrane-associated protease activities of thyrocytes and their relevance for thyroid cancer studies
... Interspecies differences in the regulation of protease ac- tivities are of particular importance because several lyso- somal and membrane-associated proteases promote tumor development and progression. The lysosomal ...
7
Binding of Transmissible Gastroenteritis Coronavirus to Cell Surface Sialoglycoproteins
... cells. Aminopeptidase N is a crucial receptor for the infection of cultured cells, whereas the sialic acid binding activity is dispensable for virus growth in cell ...with aminopeptidase N or ...
7