AMPK and mTOR
FK866-induced NAMPT inhibition activates AMPK and downregulates mTOR signaling in hepatocarcinoma cells
... Here, we investigated the effects of NAMPT inhibition by its specific inhibitor FK866 on the viability of hepatocarcinoma cells and analyzed the effects of FK866 on the nutrient sensor AMPK and mTOR complex1 ...
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Strategies of eradicating glioma cells : a multi scale mathematical model with miR 451 AMPK mTOR control
... * [email protected] Abstract The cellular dispersion and therapeutic control of glioblastoma, the most aggressive type of primary brain cancer, depends critically on the migration patterns after surgery and ...
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4-Nonylphenol induces autophagy and attenuates mTOR-p70S6K/4EBP1 signaling by modulating AMPK activation in Sertoli cells
... Whether AMPK is the critical upstream signaling that regulates mTOR and autophagy in NP-treated ...between AMPK and mTOR underlying NP-triggered ...that AMPK activation is crucial for ...
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The role of AMPK/mTOR/S6K1 signaling axis in mediating the physiological process of exercise-induced insulin sensitization in skeletal muscle of C57BL/6 mice
... Moreover, AMPK also mediates the suppression of expression of lipogenic genes, including fatty acid synthase (FAS) and acetyl- CoA carboxylase (ACC), via reduction of SREBP-1c activity [14] ...and AMPK may ...
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mir-144/451 represses the LKB1/AMPK/mTOR pathway to promote red cell precursor survival during recovery from acute anemia
... the AMPK/mTOR pathway, leading to increased ery- throid ...both AMPK and mTOR activities altered the apoptotic rate in miR-144/451 −/− ery- ...poiesis, mTOR activity is relatively high, ...
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Berberine induces autophagy in glioblastoma by targeting the AMPK/mTOR/ULK1-pathway
... There is an urgent need for new therapeutic strategies for patients with glioblastoma multiforme (GBM). Previous studies have shown that berberine (BBR), a natural plant alkaloid, has potent anti-tumor activity. However, ...
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Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: a mechanistic insight
... of AMPK. The link between AMPK activation and mTOR inhibition was shown in the OLE-fed animal model in which we found that decreased phospho-mTOR immunoreactivity and phosphorylated ...
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Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy
... that AMPK can inhibit NLRP3 by activating ...the AMPK/mTOR pathway in ...an AMPK inhibitor compound ...of mTOR, NLRP3, caspase-1, IL-1β and GSDMD-N were decreased in the diabetic model ...
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Original Article On the in vitro anti-myeloma effect and mechanism of Andrographolide through PI3K/AKT/mTOR and AMPK/mTOR dual signaling pathways
... Western blot and flow cytometry were used to detect the apoptosis-related proteins and cyclin-associated proteins in both monotherapy and combination therapy. Western blot method was employed to measure the changes of ...
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HKDC1 promotes the tumorigenesis and glycolysis in lung adenocarcinoma via regulating AMPK/mTOR signaling pathway
... regulates AMPK/mTOR signaling pathway To gain further insight into the molecular mechanism by which HKDC1 mediated oncogenic roles in LUAD, we attempted to identify the potential signaling path- way of ...
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Autophagy facilitates lung adenocarcinoma resistance to cisplatin treatment by activation of AMPK/mTOR signaling pathway
... cells. mTOR is an evolutionarily conserved serine/threonine kinase that regulates ...24 AMPK is one of the main stress-sensing enzymes and can actively regu- late metabolism and cell ...Notably, AMPK ...
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CSC-3436 switched tamoxifen-induced autophagy to apoptosis through the inhibition of AMPK/mTOR pathway
... Tamoxifen is one of highly successful adjuvant endo- crine drug for over 30 year due to its abundant, mature safety data in clinical [5] and function as an antagonist via competition with estradiol to bind to ERα and ...
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Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6 K1 signaling
... G polymorphism may influence the levels of adenosine after methotrexate treatment, which may affect the histologic response of osteosarcoma [21]. Despite these elegant observations, the significance of ATIC in human ...
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Effects of dietary tributyrin on intestinal mucosa development, mitochondrial function and AMPK-mTOR pathway in weaned pigs
... pigs. AMPK, a key energy sensor, functions in the regula- tion of cellular energy ...of AMPK significantly modulates oxidative stress and mitochondrial function [55, ...Furthermore, AMPK activation ...
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Estrogen prevents articular cartilage destruction in a mouse model of AMPK deficiency via ERK mTOR pathway
... decades, AMPK has emerged as a key mediator that regulates cellular energy metabolism in response to stress, cytokines and nutrients, which has been linked with many physiological and pathological processes ...
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Propofol inhibited autophagy through Ca2+/CaMKKβ/AMPK/mTOR pathway in OGD/R-induced neuron injury
... Methods: Cultured primary rat cerebral cortical neurons were treated with oxygen-glucose deprivation and re-oxygenation (OGD/R) to mimic cerebral I/R injury in vitro. Results: Compared with the control neurons, OGD/R ...
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<p>SLC5A1 promotes growth and proliferation of pancreatic carcinoma via glucose-dependent AMPK/mTOR signaling</p>
... an AMPK-dependent mTOR suppression. As the mTOR pathway controls several critical energy-requir- ing biological processes involving cell proliferation and survival, 31 our fi ndings have depicted an ...
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<p>Metformin Induces Autophagy via the AMPK-mTOR Signaling Pathway in Human Hepatocellular Carcinoma Cells</p>
... and AMPK can promote the initiation of autophagy. 12 Activation of AMPK can result in the inhibi- tion of mTOR, which is commonly activated in malignant ...the AMPK- mTOR signaling ...
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Ozone induces autophagy in rat chondrocytes stimulated with IL-1β through the AMPK/mTOR signaling pathway
... of AMPK inhibits inflammation by aggravating ...the AMPK/mTOR signaling pathway, ozone-induced autophagy regulating cartilaginous metabolism also acts upon other signaling pathways, such as NF- κ ...
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Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain.
... Dipti V Tillu 1 † , Ohannes K Melemedjian 1 † , Marina N Asiedu 1 , Ning Qu 1 , Milena De Felice 1 , Gregory Dussor 1,2 and Theodore J Price 1,2,3* Abstract Background: Despite advances in our understanding of basic ...
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