Amyloid and disease
Amyloid Heart Disease
... the amyloid infiltration or whether there is another ...artery disease is also an occasional feature of cardiac ...typical amyloid cardiomy- opathy, but a very small percentage of patients may have ...
15
Ubiquitination and SUMOylation of Amyloid and Amyloid-like Proteins in Health and Disease
... Overall, we can draw numerous conclusions. First, and most importantly, there is no generic function for SUMOylation or ubiquitination of amyloids. Each protein is distinct and will be impacted by PTMs differently; this ...
36
Protein chemistry of amyloid fibrils and chaperones: implications for amyloid formation and disease
... which amyloid fibrils are formed, both in vivo and in vitro, is vital for developing methods to treat and prevent debilitating deposition diseases such as Alzheimer's disease, Parkinson's disease, ...
28
Mitochondrial β amyloid in Alzheimer's disease
... c Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, United Kingdom Abstract: It is well established that the intracellular accumulation of beta-amyloid ...
11
A new era for understanding amyloid structures and disease
... onset disease and shorter disease duration (Figure 6, lower left) 101,240-243 ...of disease onset, but has also been shown to induce pyramidal signs and epilepsy 244 ...by amyloid load. This ...
54
The amyloid hypothesis of Alzheimer's disease at 25 years
... efficacious amyloid therapeutic takes noth- ing away from the need for alternative agents that target other early features of this complex and devastating ...after disease initiation, the complexity of the ...
15
Serotonin, β‐amyloid, and cognition in Parkinson disease
... stage disease feature that also shows substantial heteroge- neity in cortical plaque ...striatal amyloid burden has been described more commonly in PD with advanced cognitive impairment as opposed to early ...
9
Amyloid β-protein oligomers and Alzheimer’s disease
... brain amyloid plaques, but did have oligomers present, displayed disease symptoms ...with disease symptoms than did the number of amyloid plaques ...to disease onset ...
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The amyloid hypothesis of Alzheimer's disease at 25 years
... the amyloid b-protein (or Ab hypothesis, new lines of evidence from laboratories and clinics worldwide support the concept that an imbalance between production and clearance of A b42 and related Ab peptides is a ...
15
Alzheimer disease therapy: Can the amyloid cascade be halted?
... Monitoring disease progression using biomarkers and imaging Any disease-modifying therapy must show clinical effi- cacy in order to be approved for the treatment or pre- vention of ...on amyloid load ...
9
Florbetaben Amyloid Imaging for cognitive impairment in Parkinson’s disease
... the amyloid-negative group. This suggests that amyloid accumulation may contribute to cognitive impairment but only after a thresh- old is ...of amyloid plaques begin to accumulate, this could start ...
109
Amyloid-ß-directed immunotherapy for Alzheimer s disease
... Because amyloid deposition in the form of diffuse plaques begins as long as two decades prior to the onset of dementia symptoms, several pharmaceu- tical companies are turning their attention to prevention trials ...
12
The pathogenesis of Alzheimer's disease: a reevaluation of the "amyloid cascade hypothesis"
... to disease pathogenesis? These questions are examined in relation to studies of the morphology and molecular determinants of SPs and NFTs, the effects of gene mutation, degeneration induced by head injury, the ...
6
Inconsistencies and Controversies Surrounding the Amyloid Hypothesis of Alzheimer's Disease
... the amyloid hypothesis of AD [192], as well as up-regulating its cleavage to form Aβ ...in disease has now been acknowledged [195] and there is much evidence, from genetics and measuring indica- tory of ...
21
Evidence for impaired amyloid β clearance in Alzheimer's disease
... 1. Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, Hall K, Hasegawa K, Hendrie H, Huang Y, Jorm A, Mathers C, Men ezes PR, Rimmer E, Scazufca M; Alzheimer’s Disease International: Global ...
6
Cerebral amyloid angiopathy in the aetiology and immunotherapy of Alzheimer disease
... familial amyloid peripheral neuropathy [12], and in some families, there is deposition of mutant transthyretin in the walls of leptomenin- geal arteries and in brain parenchyma ...the amyloid in the vessel ...
13
Amyloid PET imaging: applications beyond Alzheimer’s disease
... insoluble amyloid fibrils in different organs, leading to progressive organ ...The disease is life- threatening and of insidious nature, thus diagnosis is fre- quently ...of amyloid can infiltrate ...
17
Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease
... References 1. Bard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Lieberburg I, Motter R, Nguyen M, Soriano F, Vasquez N, Weiss K, Welch B, ...
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The Alzheimer's Disease-Associated Amyloid \(\beta\)-Protein Is an Antimicrobial Peptide
... other disease has been shown to involve deposition of an AMP as amyloid, corneal ...vesicle amyloid [60] in a common sub-clinical pathology found in elderly men ...
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The Alzheimer’s Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide
... other disease has been shown to involve deposition of an AMP as amyloid, corneal ...vesicle amyloid [60] in a common sub-clinical pathology found in elderly men ...
11