Amyloid Beta
The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation?
... 3. Amyloid beta peptide is (synapto)toxic over a wide range of ...Lipid-derived amyloid beta peptide (Aβ) oligomers cause learning and memory impairments in ...
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Truncated and modified amyloid-beta species
... plaques, amyloid-beta (Aβ) peptide has been considered to play a central role in the pathology of Alzheimer’s disease (AD) ...characteristic amyloid plaques in specific brain ...of amyloid ...
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Effective screen for amyloid β aggregation inhibitor using amyloid β-conjugated gold nanoparticles
... Figure 6 TeM analysis of AuNP–Aβ42 incubated with blood-derived serum from normal and AD patients. sera from normal individuals (n = 4) and AD patients (n = 4) were incubated with AuNP–Aβ42 during aggregation. AuNP–Aβ42 ...
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Immunogenic properties of amyloid beta oligomers
... Background: The central molecule in the pathogenesis of Alzheimer ’ s disease (AD) is believed to be a small-sized polypeptide – beta amyloid (A β ) which has an ability to assemble spontaneously into ...
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Impairment of fragile X mental retardation protein-metabotropic glutamate receptor 5 signaling and its downstream cognates ras-related C3 botulinum toxin substrate 1, amyloid beta A4 precursor protein, striatal-enriched protein tyrosine phosphatase, and homer 1, in autism: a postmortem study in cerebellar vermis and superior frontal cortex
... Studies have demonstrated significantly elevated levels of secreted APP and its cleavage products, including beta amyloid (Aβ), in individuals with autism [55-57]. Our current results, particularly the ...
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Removal of blood amyloid-β with hemodialysis reduced brain amyloid-β, confirmed by brain imaging: a case report
... of amyloid-β protein (Aβ) in the brain signifies a major pathological change of Alzheimer’s disease ...Keywords: amyloid-β, Aβ, PiB/PET, blood purification, blood Aβ removal, Alzheimer’s disease, E-BARS, ...
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Pyroglutamate and Isoaspartate modified Amyloid-Beta in ageing and Alzheimer’s disease
... Interestingly, our assessment of different features of A β deposits shows that the differences between AD and controls are not only quantitative, but also related to the specific compartments of brain parenchyma and ...
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Small cisterno-lumbar gradient of phosphorylated Tau protein in geriatric patients with suspected normal pressure hydrocephalus
... [9]. Amyloid beta 1–42 (Aβ1–42, molecular mass 4514 Da), Amyloid beta 1–40 (Aβ1–40, molecular mass 4330 Da), Tau protein (Tau) and Tau protein phospho- rylated at position 181 (pTau) ...
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Passive anti-amyloid immunotherapy in Alzheimer's disease: What are the most promising targets?
... with Amyloid-beta (A β ) protein aggregation, which results in extracellular plaques in the brain, and according to the amyloid cascade hypothesis appeared to be a promising target for the ...
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The Alzheimer’s disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway
... : Amyloid-beta; A β PP: Amyloid-beta precursor protein; BSA: Bovine serum albumin; CPRG: Chlorophenol-red β -D-galactopyranoside; CSF: Cerebrospinal fluid; DAP12: DNAX activating protein of 12 ...
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The immunotherapy of Alzheimer's disease
... neurotoxic amyloid beta peptide from the brain that directly or indirectly leads to cognitive decline in patients with Alzheimer's ...the amyloid beta peptide provided suggestive evidence of a ...
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Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease
... : amyloid beta-peptide; AD: Alzheimer ’ s disease; APP: amyloid precursor protein; APPsw: Swedish familial Alzheimer ’ s disease mutant isoform of APP: BACE: beta-APP cleaving enzyme; ...
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Addition of the Aβ42/40 ratio to the cerebrospinal fluid biomarker profile increases the predictive value for underlying Alzheimer’s disease dementia in mild cognitive impairment
... : Amyloid beta; A β 40: 40-aminoacid isoform of amyloid beta; A β 42: 42-aminoacid isoform of amyloid beta; BLAD: Bateria de Lisboa para Avaliação de Demência (Lisbon Battery for ...
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Cerebrospinal fluid soluble TREM2 in aging and Alzheimer’s disease
... : amyloid beta; A β 42: amyloid beta 1 – 42; A β PP: A β precursor protein; CHO: Chinese hamster ovary; CSF: cerebrospinal fluid; CT: computed tomography; DAP12: DNAX activating protein 12; ...
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Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease - A consensus report
... Results: This review identifies a large number of biochemical markers derived from CSF and blood. There is a considerable overlap of VCI-SSVD clinical symptoms with those of Alzheimer ’ s disease (AD). Although most of ...
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Microglial pathology
... the amyloid cascade/neuroinflammation hy- pothesis, deposits of amyloid-beta (Aβ) protein incite chronic microglial activation and with it a detrimental neuroinflammatory reaction characterized by ...
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Adjusting the compass: new insights into the role of angiogenesis in Alzheimer’s disease
... the amyloid beta (A β ) pla- ques, the dominant hypothesis regarding AD (the ‘amyloid cascade hypothesis ’ ) is that this 39- to 43-amino acid A β peptide is the neurotoxic cause of brain dysfunction ...
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Prophylactic melatonin significantly reduces Alzheimer’s neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPPswe/PS1 mice
... : Amyloid-beta; A β PP swe : Amyloid-beta precursor protein, human Swedish mutation; AD: Alzheimer ’ s disease; C3B6: Mice with a combination C3H/He and C57BL/6 background; CAT: Catalase; ...
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The biochemical aftermath of anti-amyloid immunotherapy
... APP: amyloid-beta precursor protein; BBB: blood brain barrier; BSHRI: Banner Sun Health Research Institute; CAA: cerebral amyloid angiopathy; CERAD: Consortium to Establish a Registry for Alzheimer ’ ...
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Mitochondrial β amyloid in Alzheimer's disease
... Aβ, amyloid-beta peptide; ABAD, amyloid-binding alcohol dehydrogenase; AD, Alzheimer’s disease; ANT, adenine nucleotide translocase; Cdk5, cyclin-dependent kinase 5; CHANA, cyclohexenyl amine ...
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