amyloid beta protein precursor
Circulating biomarkers that predict incident dementia
... as beta-site amyloid precursor protein-cleaving enzyme 1, transthyretin, butyrylcholinesterase and choline acetyl- transferase); markers of neuronal injury (such as neuron-specific enolase), ...
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Role of Phosphoinositides in the biology of the amyloid precursor protein
... brain, amyloid plaques and neurofibrillary ...of amyloid plaques is an aggregating protein termed the beta- amyloid protein ...larger precursor protein, known as ...
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Prophylactic melatonin significantly reduces Alzheimer’s neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPPswe/PS1 mice
... : Amyloid-beta; A β PP swe : Amyloid-beta precursor protein, human Swedish mutation; AD: Alzheimer ’ s disease; C3B6: Mice with a combination C3H/He and C57BL/6 background; CAT: ...
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Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
... The APP family members are highly conserved, but despite structural similarities, APP and APLP2 have frequently been observed to have divergent and unique functions. However, both APP and APLP2 are typically upregulated ...
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The biochemical aftermath of anti-amyloid immunotherapy
... APP: amyloid-beta precursor protein; BBB: blood brain barrier; BSHRI: Banner Sun Health Research Institute; CAA: cerebral amyloid angiopathy; CERAD: Consortium to Establish a Registry ...
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Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease
... : amyloid beta-peptide; AD: Alzheimer ’ s disease; APP: amyloid precursor protein; APPsw: Swedish familial Alzheimer ’ s disease mutant isoform of APP: BACE: beta-APP cleaving ...
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The Alzheimer’s disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway
... : Amyloid-beta; A β PP: Amyloid-beta precursor protein; BSA: Bovine serum albumin; CPRG: Chlorophenol-red β -D-galactopyranoside; CSF: Cerebrospinal fluid; DAP12: DNAX activating ...
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Intracellular Trafficking Governs the Processing of the Amyloid Precursor Protein and the Secretion of Beta-Amyloid
... examine the effect of the Swedish mutation on intracellular APP trafficking, we transiently transfected SN56 cells with βAPPsw-paGFP along with plasmids expressing compartment markers for the Golgi apparatus and ...
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The Functions of the Amyloid Precursor Protein Gene and Its Derivative Peptides: I Molecular Biology and Metabolic Processing
... the amyloid precursor protein and its enzymatic ...APP beta (sAPPβ) which contains the undisrupted sequence of Aβ and serves as an intermedi- ate in the production of free Aβ through the ...
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The genetics of Alzheimer's disease
... EOAD: amyloid precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (PSEN2; Figure ...loid beta (Abeta) production (both Abeta 40 and Abeta 42), leading to apoptosis of the neurons ...
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Important advances in Alzheimer’s disease from the use of induced pluripotent stem cells
... APP: Amyloid precursor protein; ASM: Acid sphingomyelinase; A β : Amyloid-beta; BFCNs: Basal forebrain cholinergic neurons; Cdk5: Cyclin-dependent kinase 5; CNS: Central Nervous System; ...
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Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease
... vascular amyloid or senile plaques from AD and Down’s syndrome patients, the identifi cation of APP was a logical step forward ...vascular amyloid - the chromo somal location of APP also strongly argued in ...
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SORL1 gene, plasma biomarkers, and the risk of Alzheimer’s disease for the Han Chinese population in Taiwan
... (APP, PSEN1, and PSEN2) and the strongest genetic contributor to LOAD (APOE) are all involved in the pro- duction, transport, and clearance of Aβ [2, 8]. The pro- tein encoded by sortilin-related receptor 1 gene (SORL1) ...
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Neuroinflammation and related neuropathologies in APPSL mice: further value of this in vivomodel of Alzheimer’s disease
... that amyloid plaque load serves only as a general marker of AD even under condi- tions when its total concentration is very high ...mortem amyloid plaque analysis in humans is widely performed ...
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Cerebral amyloid angiopathy-related inflammation: a case report presenting with a rare variant in SORL1 gene
... Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rare clinical entity, characterized by headaches, seizures, rapidly progressive cognitive decline, behavioral changes and magnetic resonance imaging ...
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Deciphering the genesis and fate of amyloid β protein yields novel therapies for Alzheimer disease
... In an attempt to discern which species of Aβ may be synaptotoxic in vivo, we have recently taken advantage of the production by certain cultured cells of low levels (<1 nM) of highly stable oligomers (dimers, trimers, ...
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The amyloid precursor protein: beyond amyloid
... The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD) pathogenesis: APP processing generates the β-amyloid (Aβ) peptides, which are deposited as the ...
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Genetic variation in neurodegenerative diseases and its accessibility in the model organism Caenorhabditis elegans
... increase protein synthesis and extends lifespan by both activating the ribosomal subunit S6 kinase (S6K) and inhibiting 4E-BP1 (a negative regulator of translation) [81, ...aging, protein synthesis and ...
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The effect of traumatic brain injury in experimental models of Alzheimer’s disease
... brain amyloid levels compared to MCI with no history of head injury, although this association was not found in cognitively normal people with a history of head injury (Mielke et ...
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Pathological correlations between traumatic brain injury and chronic neurodegenerative diseases
... SOD1 mutant mouse models have demonstrated for- mation of SOD1 aggregates [64]. Given the role of SOD1 in detoxification of the superoxide radical [130], it was previously suggested that loss of function could cause ...
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