amyloid pathology
Myo-inositol changes precede amyloid pathology and relate to APOE genotype in Alzheimer disease
... AD pathology is responsible for MRS metabolite ...of amyloid pathology, healthy controls with abnormal levels of CSF Ab42, patients with subjective cognitive decline (SCD) with abnormal Ab42 levels, ...
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The age of onset and evolution of Braak tangle stage and Thal amyloid pathology of Alzheimer’s disease in individuals with Down syndrome
... tau pathology in subcor- tical nuclei might predate that within entorhinal/transen- torhinal areas, and that there might be stages in the tau pathological process before these latter cerebral cortical regions ...
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Ultrastructural evidence of microglial heterogeneity in Alzheimer’s disease amyloid pathology
... to amyloid pathology, some of which being specific to areas containing fAβ plaques ...of pathology (increased contacts with synaptic ...of amyloid pathology, the local environment ...
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Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology
... AD-like amyloid pathology, we tested the therapeutic effect of minocycline, a tetracyclic derivative with anti-inflammatory properties, in young, pre-plaque McGill-Thy1-APP Tg ...the amyloid ...
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Entorhinal Cortex: Antemortem Cortical Thickness and Postmortem Neurofibrillary Tangles and Amyloid Pathology
... -associated pathology within both the entorhinal cor- tex and ...neocortical amyloid- load but not entorhinal amyloid pathology, compatible with the hypothe- sis that amyloid ...
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Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer’s disease
... retinal amyloid plaque imaging as a surrogate biomarker of ...that amyloid pathology was ...Aβ pathology in the superior quadrant, along with severe thinning of the NFL and loss of mRGCs, also ...
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Reduction of β-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease
... Ab peptides are derived from the sequential proteolysis of the b-amyloid precursor protein (APP) by b- and g- secretases. The major b-secretase is an aspartyl protease termed BACE-1 (b-site APP cleaving enzyme) ...
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Effects of human intravenous immunoglobulin on amyloid pathology and neuroinflammation in a mouse model of Alzheimer’s disease
... of amyloid plaques and likely represent activated microglia around Aβ deposits ...from amyloid deposits were with comparatively longer and highly ramified processes than those seen in saline treated ...
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Peters, Finn (2018): Pharmacological BACE1 inhibitor treatment during early progression of β-amyloid pathology maximizes therapeutic efficacy. Dissertation, LMU München: Fakultät für Biologie
... the amyloid precursor protein (APP) ...of amyloid plaques can be ...of amyloid fibrils with characteristic parallel beta-pleated sheet conformation ...
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Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline
... Baseline cognitive performance and cognitive decline In the total sample, MMSE scores did not differ between the Aβ/WMH groups at baseline (Table 3, Fig. 1). Base- line MMSE scores of the individuals with MCI were lower ...
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Amyloid pathology and axonal injury after brain trauma
... PiB-PET amyloid imaging in a typical case of Alzheimer’s ...al. Amyloid imaging with carbon 11–labeled Pittsburgh compound B for trau- matic brain ...
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<p>CSF VEGF Was Positively Associated with Neurogranin Independent of β-Amyloid Pathology</p>
... Patients and Methods: In the present study, we included a total of 291 older individuals, including 83 individuals with normal cognition (NC), 143 individuals with mild cognitive impairment (MCI) and 65 patients with AD. ...
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Modulation of inflammation in transgenic models of Alzheimer’s disease
... Aβ pathology shown in PDAPP J20 [48], suppression of inflammation by overexpressing the complement inhibitory factor sCrry in P301L tau Tg mice resulted in reduced tau pathology ...tau pathology and ...
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Autophagic/lysosomal dysfunction in Alzheimer’s disease
... Whereas mTOR negatively regulates initial autopha- gosome formation, Beclin-1 regulates multiple steps of autophagy. Patients with AD express lower levels of Beclin-1 than age-matched controls and patients with other ...
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Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer’s disease
... We crossed the PolgA D257A mice with a well- established transgenic AD mouse model carrying the APP familial London mutation (APPV717I; APP/Ld). APP/Ld mice do not exhibit neuron loss but develop amyloid plaques ...
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Amyloid-independent atrophy patterns predict time to progression to dementia in mild cognitive impairment
... of amyloid pathology as measured in cerebro- spinal fluid (CSF) or on amyloid ...Since amyloid reaches a plateau relatively early in the disease course [4–6], it has limited prognostic value ...
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Alzheimer's Disease Amyloid-\(\beta\) Links Lens and Brain Pathology in Down Syndrome
... lens pathology in a 37-year-old subject with clinical features consistent with Down syndrome ...[23]. Amyloid histochemical analysis of DS lenses in the present study demonstrated Congo red staining ...as ...
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Modeling Alzheimer’s disease in transgenic rats
... the amyloid pathology including inflammation and the presence of dystrophic neurites, remain incomplete models as it does not develop “bona fide” human-like neurofibrillary ...the pathology, the ...
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High plasticity of axonal pathology in Alzheimer’s disease mouse models
... and a new AxD could be generated after a variable period of time; iii) Axonal sprouting was a common event: prom- inent morphological changes occurred in larger AxDs over time and interestingly the re-growth of long ...
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Chronic cerebral hypoperfusion induces post-stroke dementia following acute ischemic stroke in rats
... that amyloid deposit along with neu- roinflammation was significantly enhanced in the ipsilat- eral cortex of M + B rats compared to that in M + S ...and amyloid pathology leading to the ...
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