Amyloid plaques
Atypical Creutzfeldt-Jakob disease with PrP-amyloid plaques in white matter: molecular characterization and transmission to bank voles show the M1 strain signature
... All 5 p-CJDMM1 cases had a disease duration longer than one year. Three cases were classified as sporadic CJDMM1, one as sporadic CJDMM1 + 2C and one as genetic CJDE200K-MM1. Molecular mass, protease sensitivity and ...
12
A Reduced Astrocyte Response to β-Amyloid Plaques in the Ageing Brain Associates with Cognitive Impairment
... around amyloid plaques, demarcating the area for Aβ degradation, phagocytosis and a local inflammatory reac- ...that plaques that are not insulated by astrocytes have a greater toxic ef- fect on ...
15
Microglia limit the expansion of β-amyloid plaques in a mouse model of Alzheimer’s disease
... Aβ plaques [5, 7–9, ...through plaques when compared with proximal segments in the PSAPP mouse model of AD ...through plaques and were 30 μm away from Aβ plaques (Fig ...Aβ plaques ...
11
\(A\beta\) alters the connectivity of olfactory neurons in the absence of amyloid plaques in vivo
... into amyloid plaques at presymptomatic stages of Alzheimer's disease, but the temporal relationship between plaque formation and neuronal dysfunction is poorly ...
20
In vivo imaging reveals sigmoidal growth kinetic of β-amyloid plaques
... of amyloid plaques in the brains of affected individuals. Amyloid plaques mainly consist of fibrillar β -amyloid, which is a cleavage product of the amyloid precursor ...The ...
11
Strategy to enhance transgene expression in proximity of amyloid plaques in a mouse model of Alzheimer's disease
... where amyloid-beta peptides (Aβ) are present, astrocytes in proximity to plaques and throughout the neuropil contribute to the observed increase in endogenous GFAP immunoreactivity ...
11
Neuroinflammation and tumor necrosis factor signaling in the pathophysiology of Alzheimer’s disease
... senile plaques, but a 3-fold decrease in the number of acti- vated microglia in the brains of NSAID users (Mackenzie and Munoz 1998), pointing at a microglial mode of action for the protection afforded by chronic ...
12
Does statin use decrease the amount of Alzheimer disease pathology in the brain?
... WHAT IS THE RELATIONSHIP BETWEEN CHO- LESTEROL AND AD? At this time, no one knows for sure what role cholesterol plays in AD. All of us need some cholesterol in our diet in order to keep the cells in our body healthy. ...
5
Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations
... detectable NICD. A direct role for PSEN mutations in the apparent reduction of NICD expression has yet to be established. However, given the large number of genes that are activated by the NICD/CSL transcription factor, ...
18
Structural analysis and modeling comparison of primates’ amyloid ßa4 protein
... of amyloid and amyloid beta or (Aβ) is one of significant ones that is the most important portion of amyloid plaques which detected in the brain of patients with AD, in addition same ...
29
Stem cells as a promising therapeutic approach for Alzheimer’s disease: a review
... Alzheimer ’ s disease (AD) is a neurodegenerative disorder that impairs memory formation and disrupts neurocognitive function. This neuropathy is characterized by neural loss, neurodegeneration, and formation of ...
20
Elevated Aβ and Apolipoprotein E in AβPP Transgenic Mice and Its Relationship to Amyloid Accumulation in Alzheimer’s Disease
... increased amyloid burden in brain and cerebral ...of amyloid plaques in brain parenchyma, as well as more abundant CAA ...and amyloid deposi- tion also was seen after traumatic brain injury ...
10
Pathogenesis of Alzheimer's Disease: Role of Amyloid-beta and Hyperphosphorylated Tau Protein
... are amyloid-β (Aβ) peptide and hyperphosphorylated tau (p-tau) ...neuritic/amyloid plaques and is approximately a 4 kDa polypeptide, formed because of inappropriate cleavage of amyloid ...
11
Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease
... for amyloid low densities of amyloid plaques are only found in the temporal cortex and other parts of the isocortex ...neuritic plaques not with diffuse A β plaques ...
5
Modeling Alzheimer’s disease in transgenic rats
... of amyloid pathology with mature plaques The first model to develop amyloid plaques was achieved in homozygous double transgenic rats Tg478/Tg1116 expressing hAPP695 carrying the Swedish and ...
11
The effect of prolonged formalin fixation on the staining characteristics of archival human brain tissue
... for amyloid plaques, and IHC was performed to assess the expression of common molecular markers for neurodegenerative diseases using antibodies against CD 68 for microglial cells, tenascin-C (large ...
7
Clearance of Amyloid Beta Plaques from Brain of Alzheimeric Rats by Lavandula angustifolia
... Lavender family is generally known for their multi- ple pharmacological effects such as anticonvulsant, seda- tive, antispasmodic, analgesic, antioxidant and local an- esthetic activity [26]. Lavandula angustifolia ...
6
Current advances in the treatment of Alzheimer's disease: focused on considerations targeting Aβ and tau
... Non-steroidal anti-inflammatory drugs (NSAIDs) Microglial cells, closely related to the macrophage series of cells in the periphery, increase in size and number in the brain with AD. From this observation and the pres- ...
12
A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome
... both amyloid plaques and neurofibrillary tangles (NFT), typical characteristics of AD brain pathology, by age 40 and approximately two-thirds of individuals with DS develop dementia by age 60 6, 7 ...
36
Impact of amyloid β aggregate maturation on antibody treatment in APP23 mice
... single plaques in some of the mice were observed whereas in 11-month-old APP23 mice moderate numbers of plaques were ...fewer plaques stained with β1 indicating epitope masking ...B10AP-positive ...
17