amyloid Precursor
Heteromers of amyloid precursor protein in cerebrospinal fluid
... CSF: Cerebrospinal fluid; sAPP: Soluble amyloid precursor protein; sAPP α : sAPP fragment generated after α -secretase cleavage; sAPP β : sAPP fragment generated after β -secretase cleav[r] ...
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The Functions of the Amyloid Precursor Protein Gene and Its Derivative Peptides: I Molecular Biology and Metabolic Processing
... The amyloid precursor protein gene (APP) and its derivative peptides have important functions in the central nervous system. APP and A fulfil criteria as neuractive peptides: presence, release and identity ...
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Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
... Amyloid precursor protein (APP) is an evolutionarily conserved protein with two homologues in mammals: amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein ...
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Role of Phosphoinositides in the biology of the amyloid precursor protein
... brain, amyloid plaques and neurofibrillary ...of amyloid plaques is an aggregating protein termed the beta- amyloid protein ...larger precursor protein, known as the beta-amyloid ...
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The amyloid precursor protein: beyond amyloid
... The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD) pathogenesis: APP processing generates the β-amyloid (Aβ) peptides, which are deposited as the amyloid ...
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Biology and pathophysiology of the amyloid precursor protein
... of amyloid b-protein (Ab), which is a 40-42 amino acid long peptide derived by proteolytic cleavages of the amyloid precursor protein (APP), with surrounding neuritic alterations and reactive glial ...
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Intracellular Trafficking Governs the Processing of the Amyloid Precursor Protein and the Secretion of Beta-Amyloid
... the amyloid plaques, which are the other prominent feature found in ...β- amyloid (Aβ) ...the amyloid precursor protein ...of amyloid plaques [20,21] (Figure ...
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Influence of chlorpyrifos oxon on the development and progression of Alzheimer’s disease in amyloid precursor protein transgenic mice
... Figure 4: Treatment of amyloid precursor protein (APP) mice with chlorpyrifos oxon (CPO) results in diminished memory retention. The day after the last training session, the submerged platform was removed ...
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Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease
... It is important to note that not all mutations in the central region of Aβ cause CAA, as highlighted by the E693G Arctic and the E693Δ FAD mutations [26,27]. Despite changing the sequence at exactly the same posi- tion ...
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Modulation of β-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family
... Amyloid- β peptide (A β ) accumulation in the brain is an early, toxic event in the pathogenesis of Alzheimer's disease (AD). A β is produced by proteolytic processing of a transmembrane protein, β -amyloid ...
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Role of Phosphoinositides in the biology of the amyloid precursor protein
... of amyloid plaques in AD appears to follow a temporal ...A, amyloid deposits are found in the isocortex, particularly in the basal portions of the frontal, temporal and occipital ...of amyloid, ...
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Processing of Alzheimer's amyloid precursor protein in cultured cells
... than 20% of cells are SSEA-3 positive. Among the differentiated cells is a population which exhibit a neurone-like morphology. Treatment with RA for as few as 7 days is enough to induce the presence of these cells, ...
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Amyloid precursor protein modulates β-catenin degradation
... However, β -catenin accumulation in CA1 pyramidal neurons from APP knockout animals does appear to affect transcriptional activity, judging from the increases found in cyclin D1 protein[r] ...
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Studies on the amyloid precursor protein: Implications for Alzheimer's disease
... Indirect evidence supporting a role for B/A4 in the aetiology of AD came following the discovery that the gene for the B/A4 precursor protein APP, is localised to chromosome 21 (Kang et a i , 1987) and is ...
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The Functions of the Amyloid Precursor Protein Gene and Its Derivative Peptides: III Pharmacological Studies
... of amyloid plaques in AD by reducing the levels of amyloidogenic APP holoprotein as observed in cultured neurons or as- trocytes and promote neuronal regeneration ...
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Cerebral amyloid angiopathy-related inflammation: a case report presenting with a rare variant in SORL1 gene
... APP: amyloid precursor protein.; ARIA: Amyloid-related imaging abnormalities; A β : β -amyloid; A β PP: β -amyloid protein precursor; CAA: cerebral amyloid angiopathy,; ...
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Modeling Alzheimer's disease with non-transgenic rat models
... Animal models of disease are a cornerstone of the drug development process. Th eir function is to closely mimic the disease or an aspect of the disease in humans and translate the results obtained in vitro to clinical ...
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Proteomics of protein post translational modifications implicated in neurodegeneration
... [59,107-109]. Amyloid precursor protein is itself phosphorylated at T654, which is critical for subsequent cleavage into amyloid beta in a cellular neuronal AD model [110]; other PTMs occur on ...
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The genetics of Alzheimer's disease
... the Mendelian inheritance pattern; however, EOAD patients have also been reported without any family history (termed “sporadic EOAD”). Three genes are considered the main risk factors for EOAD: amyloid ...
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The autophagy related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice
... human amyloid precursor protein (APP), a model for AD, genetic reduction of Becn1 expression increased intraneuronal amyloid β (Aβ) accumulation, extracellular Aβ deposition, and neurodegeneration ...
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