amyloid precursor’s protein
Association between total-Tau and brain atrophy one year after first-ever stroke
... -42: Amyloid- β peptide-42; AD: Alzheimer ’ s disease; ApoE: Apolipoprotein E genotype; APP: Amyloid precursor protein; CSF: Cerebrospinal fluid; IQ- CODE: Informant Questionnaire on ...
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Important advances in Alzheimer’s disease from the use of induced pluripotent stem cells
... ’ s disease; ApoE4: Apolipoprotein-E4; APP: Amyloid precursor protein; ASM: Acid sphingomyelinase; A β : Amyloid-beta; BFCNs: Basal forebrain cholinergic neurons; Cdk5: Cyclin-dependent ...
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Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease
... enhanced amyloid pathology and cognitive defi cits, and Aβ43 appeared to induce the formation of Th iofl avin T-positive aggregates in vitro even more effi ciently than Aβ42 ...
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Stepping closer to treating Alzheimer’s disease patients with BACE1 inhibitor drugs
... ’ s disease (AD) is the most common age-dependent neurodegenerative disease which impairs cognitive function and gradually causes patients to be unable to lead normal daily ...of amyloid precursor ...
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Calcium/calmodulin-dependent kinase II and Alzheimer’s disease
... aggregated amyloid-β (Aβ) peptides [2–4] and hyperphosphorylated tau protein [5–8], ...the amyloid precursor protein (APP) by β- and γ-secretases, can aggregate into a toxic species, ...
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The amyloid precursor protein: beyond amyloid
... The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD) pathogenesis: APP processing generates the β-amyloid (Aβ) peptides, which are deposited as the ...
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Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease
... It is noteworthy that all substrate selective GSIs described to date are based on sulfonamide phar- macophore ([47,79,85-87], and this report). Indeed, a first generation aryl sulfonamide GSI, BMS299897 [10,11,88], was ...
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The role of APP in Alzheimer’s disease
... The amyloid precursor protein (APP) has been shown to play an important role in AD ...The amyloid β peptide (Aβ), which accumulates in senile plaques, a central etio- logical AD factor, is a ...
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The role of APP and BACE1 trafficking in APP processing and amyloid-β generation
... the amyloid-β protein (Aβ) was isolated from brains with amyloid depositon and it was subsequently identified as the core protein of neuritic plaques ...from amyloid-β precursor ...
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Biology and pathophysiology of the amyloid precursor protein
... of amyloid b-protein (Ab), which is a 40-42 amino acid long peptide derived by proteolytic cleavages of the amyloid precursor protein (APP), with surrounding neuritic alterations and ...
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Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta
... ’ s disease; AICD: Amyloid intracellular domain; APP: Amyloid precursor protein; A β : Amyloid β ; BACE1: β -secretase; CHO: Chinese hamster ovary cell line; CHX: Cycloheximide – ...
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Cerebral amyloid angiopathy-related inflammation: a case report presenting with a rare variant in SORL1 gene
... Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rare clinical entity, characterized by headaches, seizures, rapidly progressive cognitive decline, behavioral changes and magnetic resonance imaging ...
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Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer’s disease mouse model
... of amyloid β peptide (Aβ) formed and deposited in their ...β-site amyloid precursor protein cleaving enzyme 1 (BACE-1) or disintegrin and metalloproteinase domain-containing protein 10 ...
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Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
... Amyloid precursor protein (APP) and its family members amyloid precursor- like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are type 1 ...
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The immunology of traumatic brain injury: a prime target for Alzheimer’s disease prevention
... once activated – namely a phagocytic phenotype (innate activation) or the aforementioned antigen-presenting phenotype (adaptive activation) that is seen post TBI. When challenged with certain pathogen-associated mo- ...
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Zougman, Alexandre (2009): High accuracy mass spectrometric peptide identification as a discovery tool in proteomics. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... (Figure 2C). The insertion creates a new start codon and impairs the AluI-restriction site. Thus, amplification of the 200 bp sequence (Figure 2D) from AluI-treated DNA would allow identification of the modified ...
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Cognitive improvement of compound danshen in an Aβ25 35 peptide induced rat model of Alzheimer’s disease
... In the step-through passive avoidance task, all the rats took 12 s in average to enter the dark compartment, and the latency did not differ between groups (F(5,42) = 0.063, P > 0.05) (Fig. 3a) as analysed by ...
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Adult hippocampal neurogenesis and its role in Alzheimer's disease
... We have presented evidence that multiple molecular players known to contribute to AD pathogenesis, mainly ApoE, PS1, APP and its metabolites, can modulate adult hippocampal neurogenesis. The apparent discrepancies ...
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Cross-talk of membrane lipids and Alzheimer-related proteins
... A systematic analysis on the influence of membrane thickness revealed that C18 and C20 fatty acids in phos- phatidylcholine potently stimulated purified γ-secretase as compared to phosphatidylcholine with shorter C16 and ...
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Genetic variation in neurodegenerative diseases and its accessibility in the model organism Caenorhabditis elegans
... In an example of the first such class of variants, mul- tiple rare mutations in amyloid precursor protein (APP), or in the presenilin-1 and 2 genes (PSEN1 and PSEN2), can cause early-onset AD (Fig. ...
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