Amyloid-β
Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy
... both amyloid-β production in neural cells and parenchymal amyloid-β plaques, drugs need to pass through the BBB, composed of capil- lary endothelial cells, surrounded by pericytes, basal ...
16
The role of APP and BACE1 trafficking in APP processing and amyloid-β generation
... the amyloid-β protein (Aβ) was isolated from brains with amyloid depositon and it was subsequently identified as the core protein of neuritic plaques ...from amyloid-β precursor protein ...
8
The role of cerebral amyloid β accumulation in common forms of Alzheimer disease
... Alzheimer disease (AD) is the most common cause of dementia, a clinicopathological state whose name literally means “loss of the abil- ity to think.” There is much disagreement even among AD specialists about the basic ...
10
Crystal structure reveals conservation of amyloid-β conformation recognized by 3D6 following humanization to bapineuzumab
... unprocessed amyloid precursor protein (APP) (hypothesized to be a desirable attribute in a clinical candidate), and is pre- served in bapineuzumab (humanized 3D6, version 2), as reported ...compacted β- ...
13
Oligomeric forms of amyloid-β protein in plasma as a potential blood-based biomarker for Alzheimer’s disease
... A β oligomers have been analyzed using different ...A β oligomers detected using traditional ELISA were nega- tively associated with cognitive ...A β oligomers were consistently higher in both the ...
10
Decreased levels of soluble amyloid β protein precursor and β amyloid protein in cerebrospinal fluid of patients with systemic lupus erythematosus
... as β-amyloid protein (A β 42) have not been assessed at all in this ...CSF-A β 42 levels reflect either increased deposition of this molecule in senile plaques and cerebral blood vessels ...of ...
8
Deciphering the genesis and fate of amyloid β protein yields novel therapies for Alzheimer disease
... While controversy still swirls around the concept that AD is fundamentally a cerebral amyloidosis, the number of genetic, cell biological, neuropathological, and animal modeling studies that support an initiating role ...
8
RIG-1 receptor expression in the pathology of Alzheimer’s disease
... The amyloid hypothesis of AD proposes that neuronal damage results from the accumulation of insoluble, hydrophobic, fibril- lar peptides such as amyloid-β 1-42 ...
9
Cross-talk of membrane lipids and Alzheimer-related proteins
... extracellular β - amyloid plaques and intracellular neurofibrillary tangles in the ...the amyloid β -peptide (A β ), tangles are formed by fibrillar forms of the microtubule associated ...
12
Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease
... the amyloid precursor protein (APP) and the presenilin (PSEN) genes cause familial Alzheimer’s disease (FAD) with autosomal dominant inheritance and early onset of ...of amyloid-β (Aβ) peptides that ...
14
Calcium/calmodulin-dependent kinase II and Alzheimer’s disease
... aggregated amyloid-β (Aβ) peptides [2–4] and hyperphosphorylated tau protein [5–8], ...the amyloid precursor protein (APP) by β- and γ-secretases, can aggregate into a toxic species, leading ...
7
β-amyloid deposition is shifted to the vasculature and memory impairment is exacerbated when hyperhomocysteinemia is induced in APP/PS1 transgenic mice
... In the present study, we hypothesized that cerebrovas- cular disease would significantly alter AD pathological progression. To test this possibility, we administered a diet to induce HHcy in APP/PS1 transgenic mice. We ...
11
Cell adhesion molecules in Alzheimer's disease
... Collectively, CAMs orchestrate important functions in many vital physiological processes. However, increasing evidence suggests that CAMs are involved in the pathophysiol- ogy of several neurological diseases. This ...
13
The Alzheimer’s disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway
... of amyloid-β (Aβ) in amyloid deposits in AD brain and trans- genic animal models of AD [16, 19, ...A β (mixture of different lengths and aggregation states) and ApoE (isoform and lipidation ...
13
Oligomeric amyloid-beta induces MAPK-mediated activation of brain cytosolic and calcium-independent phospholipase A2 in a spatial-specific manner
... The levels of Aβ oligomers were quantified by direct ELISA with anti-human amyloid-β E22P (11A1) mouse IgG monoclonal antibody (IBL, Japan) at 1 μg/ml as pre- viously described [13, 118]. Briefly, PBS ...
17
Induced pluripotent stem cells in Alzheimer’s disease: applications for disease modeling and cell-replacement therapy
... BSI: β -secretase inhibitor; aGSK-3 β : active glycogen synthase kinase-3 β ; AD: Alzheimer ’ s disease; A β : Amyloid- β (A β ); APP: Amyloid precursor protein; ...
11
Corticosteroid therapy in a patient with cerebral amyloid angiopathy-related inflammation
... anti-amyloid β (anti-A β ) antibody, amyloid β (A β ) protein, and interleukin 8 (IL-8) in cerebrospinal fluid (CSF) of a patient with cerebral amyloid angiopathy-related ...
9
Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta
... A β generation but not AICD ...to β actin ...A β 40 and A β 42 were determined by sandwich ELISA and normalized to the levels of PS1 CTF in the corresponding ...A β amyloid ...
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Association between total-Tau and brain atrophy one year after first-ever stroke
... A β -42: Amyloid- β peptide-42; AD: Alzheimer ’ s disease; ApoE: Apolipoprotein E genotype; APP: Amyloid precursor protein; CSF: Cerebrospinal fluid; IQ- CODE: Informant Questionnaire on ...
6
Three-dimensional analysis of synapses in the transentorhinal cortex of Alzheimer’s disease patients
... extracellular amyloid plaques, primarily consisting of amyloid-β (Aβ) peptide, and intracellular neurofibrillary tangles, which consist of filamentous aggregates of hyperphosphorylated tau pro- ...
15