amyloid-β precursor protein
Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer’s disease mouse model
... A β : amyloid β peptide; AD: Alzheimer ’ s disease; APH-1: anterior pharynx- defective 1; APP: amyloid β precursor protein; BACE-1: β -site amyloid ...
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The Alzheimer’s disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway
... of amyloid-β (Aβ) in amyloid deposits in AD brain and trans- genic animal models of AD [16, 19, ...A β (mixture of different lengths and aggregation states) and ApoE (isoform and lipidation ...
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The role of APP and BACE1 trafficking in APP processing and amyloid-β generation
... the amyloid-β protein (Aβ) was isolated from brains with amyloid depositon and it was subsequently identified as the core protein of neuritic plaques ...from amyloid-β ...
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Amyloid precursor protein modulates β-catenin degradation
... induces β-catenin phosphorylation at Ser 33 , Ser 37 , and Thr 41 (S33/37/T41) residues, which is a prerequisite for β- catenin ubiquitinylation and proteasomal ...of β-catenin resulted in the ...
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Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta
... AICD: Amyloid intracellular domain; APP: Amyloid precursor protein; A β : Amyloid β ; BACE1: β -secretase; CHO: Chinese hamster ovary cell line; CHX: Cycloheximide ...
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Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease
... the amyloid hypo the- sis of AD, which argues that accumulation and aggre- gation of amyloid-β (Aβ) peptides in the brain is causal in its ...the amyloid precursor protein (APP) ...
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Decreased levels of soluble amyloid β protein precursor and β amyloid protein in cerebrospinal fluid of patients with systemic lupus erythematosus
... elevated protein levels are found in some but not all patients with CNS lupus ...as β-amyloid protein (A β 42) have not been assessed at all in this ...condition. Protein tau is ...
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Prophylactic melatonin significantly reduces Alzheimer’s neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPPswe/PS1 mice
... A β : Amyloid-beta; A β PP swe : Amyloid-beta precursor protein, human Swedish mutation; AD: Alzheimer ’ s disease; C3B6: Mice with a combination C3H/He and C57BL/6 background; ...
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Calcium/calmodulin-dependent kinase II and Alzheimer’s disease
... aggregated amyloid-β (Aβ) peptides [2–4] and hyperphosphorylated tau protein [5–8], ...the amyloid precursor protein (APP) by β- and γ-secretases, can aggregate into a ...
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Stepping closer to treating Alzheimer’s disease patients with BACE1 inhibitor drugs
... of β -amyloid peptide (A β ) is widely believed to induce pathological changes and cause dementia in brains of AD ...of amyloid precursor protein (APP) at the β -secretase ...
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Cerebral amyloid angiopathy-related inflammation: a case report presenting with a rare variant in SORL1 gene
... precursor protein (APP) processing [13, 18]. A β levels are mainly determined by the kinetic of SorLA and APP interaction according to the mathematic model which supports the fact that APP sorting ...
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Phorbol Esters Affect Multiple Steps in β-Amyloid Precursor Protein Trafficking and Amyloid β-Protein Production
... Because endocytic processing of ,BPP from the cell surface is a major pathway of AP3 produc- tion, the effect of PKC activation by phorbol 12,1 3-dibu- tyrate (PDBu) on endocytic traffic[r] ...
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Modulation of β-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family
... interact with APP and regulate its trafficking and process- ing. In this review, we have discussed several possible mechanisms by which APP trafficking and processing are regulated by LRP, LRP1B, SorLA/LR11 and ApoER2 ...
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Association between total-Tau and brain atrophy one year after first-ever stroke
... of amyloid precursor protein (APP) metabolites ...upregulate β- secretase activity associated with amyloid deposition and neuritic plaque formation ...associated protein tau ...
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Axonal and synaptic pathology in Alzheimer’s disease
... of protein synthesis required for myelin assembly also stresses the endoplasmic reticulum of oligodendrocytes, where most post-translational modifications take ...
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Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
... Amyloid precursor protein (APP) is an evolutionarily conserved protein with two homologues in mammals: amyloid precursor-like protein 1 (APLP1) and amyloid ...
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Adjusting the compass: new insights into the role of angiogenesis in Alzheimer’s disease
... fluorescent protein in vascular endothelial cells corroborated these re- ...in β-3-integrin (a specific marker of activated endothe- lium) immunoreactivity, which was restricted to amyloid- positive ...
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Decreasing the expression of PICALM reduces endocytosis and the activity of β secretase: Implications for Alzheimer's disease
... CHC protein to ...the protein level but did differentially affect the expression of isoforms 1 and 2 of PICALM, resulting in a significant decrease in isoform 2 expression to ...
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Three-dimensional analysis of synapses in the transentorhinal cortex of Alzheimer’s disease patients
... extracellular amyloid plaques, primarily consisting of amyloid-β (Aβ) peptide, and intracellular neurofibrillary tangles, which consist of filamentous aggregates of hyperphosphorylated tau pro- ...
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CYP2C19 variant mitigates Alzheimer disease pathophysiology in vivo and postmortem
... Similarly, the cognitive composite scores from the 2 cohorts have some differences that should be considered. There are also some intrinsic characteristics of the samples that have to be taken into account: (1) the ...
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