amyloid-β protein precursor
Decreased levels of soluble amyloid β protein precursor and β amyloid protein in cerebrospinal fluid of patients with systemic lupus erythematosus
... elevated protein levels are found in some but not all patients with CNS lupus ...as β-amyloid protein (A β 42) have not been assessed at all in this ...condition. Protein tau is ...
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The role of APP and BACE1 trafficking in APP processing and amyloid-β generation
... the amyloid-β protein (Aβ) was isolated from brains with amyloid depositon and it was subsequently identified as the core protein of neuritic plaques ...from amyloid-β ...
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Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease
... In retrospect it is not surprising that almost all APP mutations causative of FAD cluster around the sites of proteolytic processing by the β-secretase and γ-secretase enzymes, releasing the Aβ peptides into the ...
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Translational evidence for two distinct patterns of neuroaxonal injury in sepsis: a longitudinal, prospective translational study
... of β-amyloid peptide (Aβ), a part of the β- amyloid precursor protein (βAPP), forms neurotoxic amyloid plaques in the septic brain [14, ...by β APP staining is now ...
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Association between total-Tau and brain atrophy one year after first-ever stroke
... A β -42: Amyloid- β peptide-42; AD: Alzheimer ’ s disease; ApoE: Apolipoprotein E genotype; APP: Amyloid precursor protein; CSF: Cerebrospinal fluid; IQ- CODE: Informant ...
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Stem cells as a promising therapeutic approach for Alzheimer’s disease: a review
... APP: Amyloid precursor protein; A β plaques: Amyloid- β plaques; BDNF: Brain neurotrophic factor; BFCNs: Basal forebrain cholinergic neurons; cAMP: Cyclic adenosine ...
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The autophagy related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice
... a protein with a key role in autophagy, was decreased in affected brain regions of patients with Alzheimer disease (AD) early in the disease ...human amyloid precursor protein (APP), a model ...
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The amyloid precursor protein: beyond amyloid
... The preceding sections have highlighted the positive or beneficial functions of APP. Interestingly, there is a rather lengthy history of cytotoxic properties of APP, especially when APP or the β-cleaved C-terminal ...
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Oligomeric amyloid-beta induces MAPK-mediated activation of brain cytosolic and calcium-independent phospholipase A2 in a spatial-specific manner
... fibrillar amyloid beta (A β ) in the form of amyloid plaques and the development of intraneuronal neurofibrillary tangles consisting of aggregated hyperphosphorylated ...Although amyloid ...
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Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta
... AICD: Amyloid intracellular domain; APP: Amyloid precursor protein; A β : Amyloid β ; BACE1: β -secretase; CHO: Chinese hamster ovary cell line; CHX: Cycloheximide ...
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Stepping closer to treating Alzheimer’s disease patients with BACE1 inhibitor drugs
... of β -amyloid peptide (A β ) is widely believed to induce pathological changes and cause dementia in brains of AD ...of amyloid precursor protein (APP) at the β -secretase ...
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Induced pluripotent stem cells in Alzheimer’s disease: applications for disease modeling and cell-replacement therapy
... BSI: β -secretase inhibitor; aGSK-3 β : active glycogen synthase kinase-3 β ; AD: Alzheimer ’ s disease; A β : Amyloid- β (A β ); APP: Amyloid precursor ...
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The Alzheimer’s disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway
... of amyloid-β (Aβ) in amyloid deposits in AD brain and trans- genic animal models of AD [16, 19, ...A β (mixture of different lengths and aggregation states) and ApoE (isoform and lipidation ...
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Cerebral amyloid angiopathy-related inflammation: a case report presenting with a rare variant in SORL1 gene
... precursor protein (APP) processing [13, 18]. A β levels are mainly determined by the kinetic of SorLA and APP interaction according to the mathematic model which supports the fact that APP sorting ...
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Modulation of β-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family
... FE65 specifically bind ψXNPXpY (where ψ is a hydropho- bic residue and pY is phosphotyrosine) motifs within receptor tails [73]. APP binding to FE65 is not dependent on phosphorylation, but can be abolished by mutation ...
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Amyloid precursor protein modulates β-catenin degradation
... induces β-catenin phosphorylation at Ser 33 , Ser 37 , and Thr 41 (S33/37/T41) residues, which is a prerequisite for β- catenin ubiquitinylation and proteasomal ...of β-catenin resulted in the ...
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Prophylactic melatonin significantly reduces Alzheimer’s neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPPswe/PS1 mice
... A β : Amyloid-beta; A β PP swe : Amyloid-beta precursor protein, human Swedish mutation; AD: Alzheimer ’ s disease; C3B6: Mice with a combination C3H/He and C57BL/6 background; ...
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Calcium/calmodulin-dependent kinase II and Alzheimer’s disease
... aggregated amyloid-β (Aβ) peptides [2–4] and hyperphosphorylated tau protein [5–8], ...the amyloid precursor protein (APP) by β- and γ-secretases, can aggregate into a ...
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Cerebrospinal fluid soluble TREM2 in aging and Alzheimer’s disease
... A β : amyloid beta; A β 42: amyloid beta 1 – 42; A β PP: A β precursor protein; CHO: Chinese hamster ovary; CSF: cerebrospinal fluid; CT: computed tomography; ...
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Phorbol Esters Affect Multiple Steps in β-Amyloid Precursor Protein Trafficking and Amyloid β-Protein Production
... Because endocytic processing of ,BPP from the cell surface is a major pathway of AP3 produc- tion, the effect of PKC activation by phorbol 12,1 3-dibu- tyrate (PDBu) on endocytic traffic[r] ...
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