Amyloid β1–42
Ginkgolide B inhibits the neurotoxicity of prions or amyloid-β1-42
... to amyloid-β 1-42 ...or amyloid-β 1-42 ...and amyloid-β 1-42 induced caspase-3, a marker of apoptosis that is increased in murine scrapie [21] and AD ...or amyloid-β ...
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Evaluation of the inhibitory effect of docosahexaenoic acid and arachidonic acid on the initial stage of amyloid β1 42 polymerization by fluorescence correlation spectroscopy
... membrane-bound amyloid precursor proteins [2], constitutes the foremost component of neuritic plaques and tangles of the affected brains [3] and plays an important role in neurobehavioral impairments in AD ...
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Crocetin Prevents Amyloid β1 42 Induced Cell Death in Murine Hippocampal Cells
... Crocetin is an aglycon of carotenoid extracted by saffron stigmas (Crocus sativus L.) and known to have a potent anti-oxidative effect. Amyliod β (Aβ), hallmark of Alzheimer’s disease, is reported to have neurotoxicity ...
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α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes
... : Amyloid β ; CARD: Caspase activation and recruitment domain; Casp1: Caspase 1; CNS: Central nervous system; Ctr: Control; DMSO: Dimethylsulfoxid; GAPDH: Glycerinaldehyd-3-phosphate-dehydrogenase; GFAP: Glial ...
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Requiring an amyloid-β1-42 biomarker may improve the efficiency of a study, and simulations may help in planning studies
... Four diff erent defi nitions of eff ect size will be com pared: one that is unstandardised (the absolute diff erence); and three that are standardised values, calculated through dividing [r] ...
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Ginkgolides protect against amyloid-β1–42-mediated synapse damage in vitro
... content of cortical neurons; 5 nM PAF reduced synapto- physin content by 50%. The effects of PAF are transmitted via a G-protein coupled receptor [29] and the addition of lyso-PAF, a non-acetylated structural analogue of ...
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Original Article Genistein protects against rat hippocampus amyloid-β1-42 neurotoxicity through p-mTOR-dependent autophagy
... phytoestrogen. Gen can be found in a number of plants, including soybeans, lupin, fava beans, kudzu, and psoralea in food sources, as well as in the medicinal plants, Flemingia vestita and F. macrophylla. In 2015, a ...
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Endothelial LRP1 transports amyloid β1–42 across the blood brain barrier
... Accumulation of amyloid-β (Aβ) in the brain is a key event in Alz- heimer’s disease (AD) pathogenesis. Recent evidence suggests that in the common sporadic or late-onset forms of AD and in some cases of familiar ...
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α-synuclein induced synapse damage is enhanced by amyloid-β1-42
... with amyloid-b (Ab) peptides that are thought to trigger synapse degeneration in Alzheimer’s ...of amyloid-b (Ab) 1-42 exacerbated the effects of aSN on synaptic vesicle recycling ...
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Interferon-γ increases neuronal death in response to amyloid-β1-42
... that amyloid-β peptides activate PLA 2 [15], that PLA 2 inhibitors protect against the amy- loid-β 1-42 induced neurotoxicity [16], and more specifi- cally, that the cPLA 2 isoform is required for induced ...
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Clinical validation of the Lumipulse G cerebrospinal fluid assays for routine diagnosis of Alzheimer’s disease
... the 42-aminoacid isoform of amyloid beta (Aβ42) and high levels of total tau (t-Tau) and phosphorylated tau (p-Tau) is thought to reflect the two widely accepted pathophysiological hallmarks of AD: ...
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Amyloid-beta 42 adsorption following serial tube transfer
... (CSF) amyloid beta 38 (A β 38), amyl- oid beta 40 (Aβ40), amyloid beta 42 (Aβ42) and total tau (T-tau) are protein biomarkers used in the clinical diagno- sis and research analysis of, and drug ...
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Aβ43 in human Alzheimer’s disease: effects of active Aβ42 immunization
... Using immunoassays, we showed that the 21F12 anti- body, often used for its assumed Aβ42-specificity, also recognized Aβ43, albeit more weakly. This observation has been shared and acknowledged by many researchers ...
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Advantages and disadvantages of the use of the CSF Amyloid β (Aβ) 42/40 ratio in the diagnosis of Alzheimer’s Disease
... β amyloid precursor protein pathways with a general decline in the production of ...between amyloid alterations reflected in the CSF with those in Aβ-PET in a cohort of 199 ...Aβ 42/40 ratio ...
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The role of the LRRK2 gene in Parkinsonism
... However, to date, most genetic screens have been limited to PD clinic populations, with only a few studies referring to other neurodegenerative diseases. LRRK2 mutation has been assumed to play an upstream influence on ...
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Conflicting cerebrospinal fluid biomarkers and progression to dementia due to Alzheimer’s disease
... The study sample encompassed data from all phases of the AD Neuroimaging Initiative (ADNI) (ADNI 1, Go and 2), a collaborative project of academic institutions and pri- vate corporations across the USA and Canada which ...
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For debate: substituting placebo controls in long-term Alzheimer's prevention trials
... A β 42: amyloid β 42; AD: Alzheimer ’ s disease; ADAScog: Alzheimer Disease Assessment Scale - cognitive subscale; ADNI: Alzheimer Disease Neuroimaging Initiative; FAQ: Functional Assess[r] ...
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Identification of novel CSF biomarkers for neurodegeneration and their validation by a high-throughput multiplexed targeted proteomic assay
... β amyloid 1 – 42 (A β 42), total tau protein (h-tau), and phosphory- lated tau 181 (p-tau) assays; these are now well estab- lished as diagnostic biomarkers of AD and have entered routine clinical ...
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The protective effect of crocin on the amyloid fibril formation of aβ42 peptide in vitro
... monomers includes the formation of pentamer/hexamer units that are called paranuclei. Paranuclei are the most basic and smallest structures that can be oligomerized into larger forms involving large oligomers, ...
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Conjugated Quantum Dots Inhibit the Amyloid β (1 42) Fibrillation Process
... 3.1.1. Estimation of Aβ/QDs Ratio. To characterize the QDs conjugated to Aβ (1–42), it is important to estimate the number of Aβ monomers bound to QDs after conjugation. Firstly, characterization of samples of ...
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