AN ALTERNATIVE SPLICING NETWORK LINKS CELL-CYCLE
Alternative splicing links histone modifications to stem cell fate decision
... of alternative splicing events upon hESC ...for cell differentiation, whereas other alternatively spliced genes are enriched in the G1 phase and pathways for ...of alternative splicing ...
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The landscape of alternative splicing in cervical squamous cell carcinoma
... Dovepress guo et al The carcinogenesis due to HPV depends on the activities of viral oncoproteins E5, E6, and E7, which inhibit various cellular targets, including the tumor suppressor proteins p53, pRb, p21, and p27, as ...
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The effect of hypoxia on alternative splicing in prostate cancer cell lines
... the splicing of the APC and LRP8 genes in the ...on alternative splicing in both non-cancerous and cancerous cell lines have identified various changes to splicing patterns in genes ...
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Classification of clear cell renal cell carcinoma based on PKM alternative splicing
... pre-mRNA splicing and could interact with well-known oncogene PIM-1 ( Maita et ...tumor cell apoptosis ( Chen et ...suppress cell cycle progression in HCT116 cells ( Yan et ...suppressed ...
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Computational extraction of a neural molecular network through alternative splicing
... its alternative splicing to repress gene ...glial cell stage of P19 ...tive splicing have been observed in other genes during differentiation ...neuronal cell stage of P19 cells (Figure ...
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SRSF10 Connects DNA Damage to the Alternative Splicing of Transcripts Encoding Apoptosis, Cell-Cycle Control, and DNA Repair Factors
... and cell-cycle control, and hence are associated with the DNA damage ...controls cell-cycle G2/M checkpoints and that interacts with BRCA1 to regulate the acti- vation of ...induce ...
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The splicing inhibitor isoginkgetin leads to defects in multiple phases of the cell cycle
... the splicing of an intron even after the splice site ...the alternative splicing of first apoptosis signal (Fas) cell surface death receptor exon 6 (Bonnal et al, ...
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Alternative polyadenylation factors link cell cycle to migration.
... Results: RNA sequencing of fibroblasts induced into quiescence by contact inhibition reveals downregulation of genes involved in mRNA processing, including splicing and cleavage and polyadenylation factors. These ...
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Alternative polyadenylation factors link cell cycle to migration
... Results: RNA sequencing of fibroblasts induced into quiescence by contact inhibition reveals downregulation of genes involved in mRNA processing, including splicing and cleavage and polyadenylation factors. These ...
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Prognostic role of alternative splicing events in head and neck squamous cell carcinoma
... et al. carried out a systemic bioinformatic analysis on the genome-wide AS events of clinical HNSCC sam- ples from the TCGA database [31]. However, this study failed to identify AS events as independent prognostic ...
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Transcription Factors in Cancer: When Alternative Splicing Determines Opposite Cell Fates
... of cell proliferation, cell death and key metabolic genes [ 22 ...supports cell proliferation, in opposition to NF-YAl, which correlates with induced differentiation [ 24 , 25 ...of cell ...
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Alternative splicing and single-cell RNA-sequencing: a feasibility assessment
... or cell type specific expression of isoforms, are a potential confounder when studying splicing using ...for cell type specific expression of isoforms, thus are not comprehensive models of all ...
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Alternative splicing of the neural cell adhesion molecule and the differential diagnosis of neuroblastoma
... The fact that MoAb UJ13A consistently yields a stronger fluorescence signal suggests that it either binds with greater avidity than MoAb ERIC-1, or alternatively, that the epitope of MoAb ERIC-1 is partially m asked (see ...
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BRANCHLESS TRICHOMES links cell shape and cell cycle control in Arabidopsis trichomes
... increases trichome nuclear DNA content (Fig. 4C), whereas STI overexpression has no effect on DNA content (Ilgenfritz et al., 2003). Our data suggest that, in addition to its role in promoting branch formation, BLT ...
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The Alternative Splicing Mutation Database: a hub for investigations of alternative splicing using mutational evidence
... observed alternative splicing events for a gene or exon of interest, a researcher using ASMD can expect to find a curated list of small mutations that are correlated with alternative splicing ...
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A study of alternative splicing in the pig
... candidate alternative isoforms were identified in the EST data with high ...tissue-specific alternative splice events was generated from the list of ...of alternative spliced ...
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Pharmacology of Modulators of Alternative Splicing
... splicing is the ...For alternative splic- ing, the key point is whether the alternative splicing is modulated, and the target may not be identified ...affect splicing of the specific ...
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Alternative Splicing in Apicomplexan Parasites
... ABSTRACT Alternative splicing is a widespread, essential, and complex component of gene ...of alternative splicing; some indicate that alternative splicing is less widespread ...
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Alternative splicing in plant defence
... 82 When performing RNA-Seq a small proportion of partially processed transcripts that have not had their introns spliced out can be sequenced. To prevent these transcripts being counted as RI events Cooke (2013) ...
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Pharmacology of modulators of alternative splicing
... target alternative splicing in disease states, and some of these have now reached the clinical trial stage, with surprising, sometimes promisingly efficacious, ...target splicing raises a number of ...
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