Anaplastic Thyroid Cancer
<p>miR-19a Is Involved In Progression And Malignancy Of Anaplastic Thyroid Cancer Cells</p>
... Although miR-17-92 members all belong to the same family, they may act both as part of the same pattern or independently. Speci fi cally, miR-17-5p is a key regulator of the G1/S phase cell cycle transition and target ...
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Diagnosis and Management of an Anaplastic Thyroid Cancer: Case Report
... of anaplastic thyroid cancers can develop rapidly by invading surrounding local tissues and metastases into distant ...Locally, anaplastic thyroid cancer shows rapid anterior neck ...
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Treatment Outcome of Patients with Anaplastic Thyroid Cancer: A Single Center Experience
... Purpose: Anaplastic thyroid cancer is known to have a poor prognosis due to its aggressive and rapid metastasis with median survival of less than 6 ...13 anaplastic thy- roid cancer ...
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Efficacy of lenvatinib in a patient with anaplastic thyroid cancer
... diffuse thyroid neoplasms causing significant tracheal stenosis with tumors, particularly of the superior mediastinum, which were associated with an embolism of the brachiocephalic vein and suspected invasion to ...
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Clinical Response with Sunitinib Therapy in the Treatment of Anaplastic Thyroid Cancer
... Anaplastic thyroid cancer (ATC) is the least common thyroid malignancy, but carries an extremely poor pro- gnosis. The female to male ratio is 5:1 and peak inci- dence is in the sixth and ...
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Biochemical effects of combined action of γ-irradiation and paclitaxel on anaplastic thyroid cancer cells
... P aclitaxel (Ptx) is one of the most effective anticancer drugs, which has been used to treat certain types of malignant tumors, including cancer of lung, breast, bladder, ovary, head and neck, and melanoma [1, ...
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Torin2 targets dysregulated pathways in anaplastic thyroid cancer and inhibits tumor growth and metastasis
... Anaplastic thyroid cancer (ATC) is one of the most deadly solid human ...all thyroid cancers, has an annual incidence of 1-2 cases per million population per year but accounts for nearly ...
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Anaplastic Thyroid Cancer: Ultrasonographic Findings and the Role of Ultrasonography Guided Fine Needle Aspiration Biopsy
... Purpose: To investigate the ultrasonographic (US) features of anaplastic thyroid cancer (ATC) and the diagnostic performance of US-guided fine needle aspiration biopsy (FNAB) therein. Materials and ...
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The role of chemotherapy and latest emerging target therapies in anaplastic thyroid cancer
... Abstract: Anaplastic thyroid cancer represents 1%–2% of thyroid ...with anaplastic thyroid cancer has changed little in the past 50 years, despite more aggressive systemic ...
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Carfilzomib potentiates CUDC-101-induced apoptosis in anaplastic thyroid cancer
... Anaplastic thyroid cancer (ATC) is one of the most aggressive human malignancies, with no effective treatment currently available. Previously, we identified agents active against ATC cells, both in ...
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Original Article Galunisertib, a TGF-β receptor (TβR)-I inhibitor, suppresses growth and invasion of an anaplastic thyroid cancer 8505C cell in vitro and in vivo
... Abstract: Background and objective: The transforming growth factor-beta (TGF-β) signaling pathway is known to play a critical role in promoting tumor growth and metastasis. Blocking this pathway has been found to inhibit ...
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Genetic mutations in the treatment of anaplastic thyroid cancer: a systematic review
... differentiated tumors in their early stages. Moreover, the application of molecular techniques to FNC has dramati- cally increased its sensitivity [3,4,6-9]. An effective FNC diagnosis avoids useless diagnostic surgery ...
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Role of tyrosine kinase inhibitor therapy in anaplastic thyroid cancer
... Anaplastic thyroid cancer (ATC) is a rare but deadly form of thyroid ...all thyroid cancer cases each year, the relative 5-year survival of patients diagnosed with this ...
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Molecular mechanisms of long non-coding RNAs in anaplastic thyroid cancer: a systematic review
... : anaplastic thyroid cancer; BANCR: BRAF‑activated non‑protein coding RNA; BCL2: BCL2 apoptosis regulator; BCYRN1: brain cytoplasmic RNA 1; BRAF: B‑raf proto‑oncogene; CASC2: cancer ...
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A Large Nonmetastatic Anaplastic Thyroid Cancer with Complete Thyroidal Confinement
... cited. Anaplastic thyroid cancer (ATC) is rare but extremely aggressive, which accounts for about 2% of all thyroid cancers yet nearly 50% of thyroid-cancer-associated deaths in ...
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Overcoming the lack of expression of the sodium iodide symporter protein in anaplastic thyroid cancer stem cells by targeting the phosphatidyl inositol 3 kinase signaling pathway
... expression. Several previous studies demonstrated that PI3K gene mutation has a notable role in promoting ATC (García- Rostán et al. 2005; Charles et al. 2014). Therefore, our results suggest that CD133 pos CSCs may have ...
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Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis
... We exploited Obatoclax autofluorescence to determine its subcellular localization in thyroid cells. Confocal imaging of live cells within a few minutes of treatment showed a cytoplasmic punctate pattern in both ...
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Original Article PUMA enhances sensitivity of anaplastic thyroid carcinoma cells to cisplatin
... Anaplastic thyroid cancer (ATC) represents 1%- 2% of all thyroid tumors and is characterized by aggressive, local invasion and common distant ...on Cancer (AJCC) defines all of its ...
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Novel leptin OB3 peptide-induced signaling and progression in thyroid cancers: Comparison with leptin
... different thyroid cancer cells for gene expression, proliferation and ...in anaplastic thyroid cancer ...on thyroid cancer ...
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Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy
... ATC: Anaplastic thyroid cancer; BPI: Brief Pain Inventory; CBR: Clinical benefit rate; cHL: Classical Hodgkin lymphoma; CNS: Central nervous system; CRC: Colorectal cancer; CSF1: ...
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