and 5 disubstituted 2
BIOLOGICAL SCREENING (IN VITRO) OF SOME 2, 5 DISUBSTITUTED OXADIAZOLE DERIVATIVES
... A series of novel 2,5-disubstituted 1,3,4-oxadiazole derivativeswere synthesized by convergent synthesis using various aromatic aldehydes. The structures of synthesized compounds have been elucidated by spectral ...
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Synthesis and biological screening of 5-{[(4,6-disubstituted pyrimidine-2-yl)thio]methyl}-N-phenyl-1,3,4-thiadiazol-2-amines
... afforded 2-[(4,6-disubstitutedpyrimidine- 2-yl) thio] acetohydrazides (4a-c), which on condensation with phenyl isothiocyanate in ethanol gave 2-{[(4,6-disubstituted pyrimidine-2-yl) ...
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SYNTHESIS AND IN VITRO ANTIOXIDANT ACTIVITY OF SOME NEW 2, 5 DISUBSTITUTED 1, 3, 4 OXADIAZOLES CONTAINING FURAN MOIETY
... 1, 3, 4-oxadiazoles [DM (1-6)], and was tested for their antioxidant activity. The synthesized compounds were characterized by IR, 1 HNMR and Mass Spectroscopy. All the compounds were screened for in vitro antioxidant ...
5
MICROWAVE-ASSISTED, SOLVENT FREE AND PARALLEL SYNTHESIS OF SOME NEWER 2, 4-DISUBSTITUTED 1, 5- BENZODIAZEPINES OF BIOLOGICAL INTEREST
... 1, 2-diamine under smooth condensation with chalcones in presence of glacial acetic acid afforded a new class of 1, 5-benzodiazepines in good ...yield. 2, 4-disubstituted 1, ...
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SYNTHESIS, ANTICONVULSANT AND NEUROTOXICITY SCREENING OF SOME NOVEL 2, 5-DISUBSTITUTED - 1, 3, 4 – OXADIAZOLE DERIVATIVES
... An equimolar quantity of 4-carbomethoxy-2- aminophenol (0.01mol) and hydrazine hydrate (99%, 0.01mol) was taken in absolute ethanol (30 ml) and refluxed for 20 hours. After this reaction mixture was poured to ...
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Synthesis and Characterization of 2, 5-Disubstituted-1, 3, 4-oxadiazoles as Potential Anti-inß ammatory Agents
... To the product (II) (0.01 mol), various aromatic acids (0.01 mol) were added and reß uxed in the presence of phosphorous oxychloride for 6 h. The reaction mixture was cooled and poured into crushed ice. The resulting ...
5
SYNTHESIS & PREDICTING THE POSSIBILITY OF 2, 5 DISUBSTITUTED 1, 3, 4 OXADIAZOLE DERIVATIVES AS GSK 3β INHIBITORS
... the 2 nd & 4 th position of 1, 3, 4-oxadiazole when compared with the standard GSK-3beta ...these 2, 5- disubstituted-1, 3, 4-oxadiazoles are good GSK-3beta ...
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Synthesis and characterization of some new 3, 5 disubstituted pyrimidine and thiopyrimidine derivatives
... A mixture of 1-(1-(5-chloro-2-hydroxyphenyl)-3-(4-methoxyphenyl)-prop-2-en-1-one (2a-e) (0.01 mol) and urea (0.01 mole) in ethanol (30 ml) containing alcoholic KOH (1mL) were refluxed for 12 hours. ...
5
“A Facile Green Synthesis of 1, 3-Disubstituted-(1h,3h)-6-Methylpyrimidine-2,4-Diones through Chapman Rearrangement of 2, 4-Diaryloxy-6-Methylpyrimidines” by M. M. V. Ramana, Sanjay C. Pawar, India.
... slowly refluxed for 5-6 hours under dry conditions. After completion of the reaction (TLC), the acetone was recovered by flash distillation. The reaction mass was cooled to room temperature and quenched in water ...
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Synthesis and antitubercular activity of some new 2, 3 disubstituted quinazolinones
... Heterocyclic compounds are abundant in nature and are of great significance to life because their structural subunits exist in many natural products such as vitamins, hormones, antibiotics etc. A practical method for the ...
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Phospho Sulfonic Acid Catalyzed Synthesis of Benzimidazole, Benzoxazole and Quinoxaline Derivatives under Green Solvent at Ambient Temperature
... benzimidazole and benzoxazole derivatives are found in a variety of natural products and wide range of biologically active compound, especially including anti ulcerative, antihypertensive, antiviral, antimicrobial, ...
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Vol 3, No 8 (2014)
... Continuing the ongoing interest in the study of the reactivity of benzotiazolated derivatives and its application for the synthesis of heterocycles, an easy preparation of C- benzotriazolated nitrones 3 and the ...
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Montmorillonite K-10 Supported La(OTf)3: An Efficient Catalyst for the Synthesis of 1,2-Disubstituted Benzimidazoles
... Catalyst reusability has been checked with the synthesis of 4a operated under optimized conditions for articulating the cost-effectiveness of this protocol. The catalyst after the reaction was filtered off and thoroughly ...
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Synthesis and characterization of some new 3, 5 disubstituted pyrazoline and isoxazoline derivatives
... The development of simple, facile and efficient synthetic methods for the synthesis of five member heterocycles from readily available reagents is one of the major challenges in organic synthesis. Among five member ...
5
Synthesis and antidiabetic activity of 2, 4 disubstituted furan derivatives
... [11] 4- (a) Kazlauskas, R.; Murphy, P. T.; Wells, R. J.; Daly, J. J.; Schoenholzer, P. Tetrahedron Lett. 1978, 19, 4951-4954. (b) Richou,O.; Vaillancourt, V.; Faulkner, D. J.; Albizati, K. F. J. Org. Chem. 1989,54, ...
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SELECTIVE SYNTHESIS OF 2-CHLORO-N-ALKYL-7- NITROQUINAZOLIN-4-AMINES DERIVATIVES FROM 2, 4 DICHLORO 7 NITRO QUINAZOLINE BY CONTROL REACTION CONDITIONSDr. S. S. Thakare* Mr. S. P. KakadDOWNLOAD/VIEW
... to 5% disubstituted compounds also formed with desire product, it is concluded that disubstituted compound formed in high reaction temperature and low dilution, on the basis of bond dissociation ...
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Synthesis and Biological Activity of Novel 2, 5- Disubstituted Benzimidazole Derivatives.
... Benzimidazoles are five membered benzoheterocyclic compounds containing two hetero atoms. Both hetero atoms are nitrogen, which are present at non-adjacent position. Benzimidazole derivatives belong to a crucial ...
165
SYNTHESIS OF MONO-SUBSTITUTED AND SIMMETRICALLY 2, 5-DISUBSTITUTED 1, 3, 4-OXADIAZOLES
... Hereby, the various ways of synthesis for mono-substituted and symmetrically 2,5-disubstituted 1,3,4-oxadiazoles have been analyzed. The important structural characteristic of 2,5-disubstituted ...
7
Synthesis of 2, 5-disubstituted-1, 3, 4-oxadiazole derivatives
... separated and dried over anhydrous sodium sulphate. The solvent was evaporated under vaccum and the residue (liquid product) thus obtained was used for next step. Yield % : 96.56% (3a), 92.53% (3b), 90.97% (3c) TLC : ...
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Novel 3,4-methylenedioxybenzene scaffold incorporated 1,3,5-trisubstituted-2-pyrazolines: Synthesis, characterization and evaluation for chemotherapeutic activity
... 1-phenyl-3,5-disubstituted 2-pyrazolines 3a-g suggested that the activity did not increase in a dose dependant ...drug 5-fluorouracil exhibited cytotoxicity that was found to be linear with its ...
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