and hepatocyte nuclear factor-4
Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4
... receptor hepatocyte nuclear factor 4 (HNF-4), which binds to the NHRRE, dramatically stimulates apoAI gene expression in Caco-2 cells but not in HepG2 ...
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Mesenchymal stem cells overexpressing hepatocyte nuclear factor-4 alpha alleviate liver injury by modulating anti-inflammatory functions in mice
... Mesenchymal stem cells (MSCs) were isolated from the bone marrow of 6–8-week-old mice. After passaging three times, MSCs were identified by their ability to dif- ferentiate into adipocytes and osteoblasts (Add- itional ...
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Study of the expression levels of Hepatocyte nuclear factor 4 alpha and 3 beta in patients with different outcome of HBV infection
... Hepatocyte nuclear factors 4 alpha (HNF4a) and 3 beta (HNF3b) are members of a group of liver-enriched transcription factors (LETFs) that play important roles in regulating the replication of ...
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Mutations in the coding regions of the hepatocyte nuclear factor 4 alpha in Iranian families with maturity onset diabetes of the young
... Hepatocyte nuclear factor 4α (HNF4α) is a nuclear receptor involved in glucose homeostasis and is required for normal β cell ...predisposing factor for developing diabetes in ...
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Suppression of Hepatocyte Nuclear Factor 4 Alpha by Long-Term Infection of Hepatitis B Virus Contributes to Tumor Cell Proliferation
... HNF4α was identified as a nuclear factor which exists abundantly in the liver and controls the transcription of many genes involved in hepatocyte function [9, 11]. Different roles of HNF4α have been ...
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A missense mutation in hepatocyte nuclear factor 4 alpha, resulting in a reduced transactivation activity, in human late onset non insulin dependent diabetes mellitus
... HNF- 4 a 2 was generated from the wild-type human HNF-4 a 2 isoform (18) cloned in the expression vector pSG5 using the Stratagene ExSite™ PCR-based site-directed mutagenesis kit according to the manufac- ...
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Role of hepatocyte nuclear factor 4 alpha in cell proliferation and gemcitabine resistance in pancreatic adenocarcinoma
... that affecting the uptake of nucleoside analogs. A study has reported that although the mRNA level of hENT1 in chronic lymphocytic leukemia cells is increased with the presence of interleukin 4 (IL-4), the ...
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Retinoid X receptor alpha transactivates the hepatitis B virus enhancer 1 element by forming a heterodimeric complex with the peroxisome proliferator-activated receptor.
... Moreover, nuclear receptors exert diverse effects upon cell differentiation, morphogenesis, and carcinogenesis (2, 10, 12, ...(PPAR); hepatocyte nuclear factor-4 (HNF-4); chicken ...
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Association of sex hormone-binding globulin with nonalcoholic fatty liver disease in Chinese adults
... receptor hepatocyte nuclear factor 4-α (HNF4α) activates the promoters of multiple genes expressed in he- patocytes that play a role in lipoprotein metabolism ...transcription factor ...
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Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers
... Results: WGBS analyses in liver identified 969 hypermethylated and 871 hypomethylated differentially methyl‑ ated regions (DMRs) specifically identifying patients with WD, including 18 regions with genome‑wide ...
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Functional interaction of nuclear factors EF-C, HNF-4, and RXR alpha with hepatitis B virus enhancer I.
... The nucleotide sequence of the GB element is similar to the sequences of binding sites of liver-enriched nuclear proteins HNF-4 hepatocyte nuclear factor 4 42 and RXRot retinoid X recept[r] ...
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A review on hepatocyte nuclear factor-1beta and tumor
... peptidase 4 (DPP4), and osteopontin (SPP1) are most likely direct target genes, as they contain functional HNF1 binding sites in their promoter ...(Tissue factor pathway inhibitor 2) are proteases involved ...
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Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left right asymmetry
... nuclear factor/forkhead homologue (HFH)-4 is a 421–amino acid member of the winged helix family (16, 17). Expression of HFH-4 in mice and humans has been localized to the lung, spermatids, ...
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Hepatocyte Nuclear Factor 3β Inhibits Hepatitis B Virus Replication In Vivo
... studies, 4-week old HBV transgenic mice that lacked the rat HNF3 transgene were used as controls and compared with their rat HNF3-expressing HBV transgenic ...
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Mechanisms of Inhibition of Nuclear Hormone Receptor-Dependent Hepatitis B Virus Replication by Hepatocyte Nuclear Factor 3β
... vations that HNF3 recognition sequences are present in all the HBV promoters and transcription of the pregenomic RNA requires that RNA synthesis transverses these regulatory re- gions suggest HNF3 might inhibit ...
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The impact of hepatocyte nuclear factor-1α on liver malignancies and cell stemness with metabolic consequences
... Although HNF-1α impacts a wide range of organs, the hepatic responses are most pronounced due to its higher concentration and local production. For instance, it showed hints of effectiveness in NAFLD and hepatic fibro- ...
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Inhibition of Hepatitis B Virus Gene Expression and Replication by Hepatocyte Nuclear Factor 6
... HBV DNA analysis. HepG2 cells were cotransfected with pHBV1.3, pSV-  -gal, and HNF6 or its control vector pcDNA3.1 in the amounts as indicated in the related figures or legends. At 96 h posttransfection, the cells were ...
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Development of Simple Protocol for Generation of Functionally Active Hepatocyte-like Cells from Human Adipose Tissue-derived Stem Cells
... Based on the mentioned results clearly confirming the important role of FGF4 in liver development and regeneration, in this study we examined a new protocol to induce hASCs toward functional hepatocyte-like cells. ...
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A complex microdeletion 17q12 phenotype in a patient with recurrent de novo membranous nephropathy
... the hepatocyte nuclear factor 1β ( HNF1β) have recently been characterized as an important cause of prenatally hyperechogenic kidneys, renal aplasia and renal hypo- dysplasia, which represent an ...
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Original Article miR-107 promotes hepatocellular carcinoma cell proliferation by targeting Axin2
... Hepatocellular carcinoma (HCC), which acc- ounts for about 95% of all primary liver can- cers, has become the third most frequent cause of cancer-related mortality worldwide [1, 2]. Each year, more than 700,000 patients ...
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