and tissue-type plasminogen activator
Preventing graft restenosis after coronary artery bypass grafting with tissue-type plasminogen activator
... Objective: To explore the feasibility and safety of using tissue-type plasminogen activator (t-PA) to prevent graft restenosis after coronary artery bypass grafting (CABG).. Methods: [r] ...
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alpha Fucose mediated binding and degradation of tissue type plasminogen activator by HepG2 cells
... Binding and degradation of tissue-type plasminogen activator by the human hepatoma cell line HepG2.. Interactions between tissue-type plasminogen activator and extracellular matrix assoc[r] ...
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39 kD protein inhibits tissue type plasminogen activator clearance in vivo
... Tissue-type plasminogen activator (t-PA) is a plasma serine protease that catalyzes the initial and rate-limiting step in the fibrinolytic ...
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Recombinant plasminogen activator inhibitor 1 reverses the bleeding tendency associated with the combined administration of tissue type plasminogen activator and aspirin in rabbits
... The major side effect of thrombolytic therapy is bleeding; however, the pathogenesis of this potential complication is not well understood. Accordingly, we examined the effects of aspirin and recombinant human ...
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Influence of the fast acting inhibitor of plasminogen activator on in vivo thrombolysis induced by tissue type plasminogen activator in rabbits Interference of tissue derived components
... of plasminogen activator (PA-inhibitor) on thrombolysis was investigated in rabbits with a jugular vein ...human tissue-type plasminogen activator (t-PA) produced similar degrees ...
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Regulation of seizure spreading by neuroserpin and tissue type plasminogen activator is plasminogen independent
... Tissue-type plasminogen activator (tPA) is a highly specific serine proteinase expressed in the CNS during events that require neuronal ...contrast, plasminogen-deficient mice show a ...
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Tissue type plasminogen activator induces opening of the blood brain barrier via the LDL receptor–related protein
... endogenous tissue-type plasminogen activator (tPA) activity in the perivascular tissue following cerebral ischemia induces opening of the BBB via a mechanism that is independent of both ...
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Tissue-Type Plasminogen Activator, Plasminogen Activator Inhibitor, and Histidine-Rich Glycoproteins in Stressed Human Newborns
... Tissue-type plasminogen activator antigen was determined by an enzyme-linked immuno- sorbent assay (ELISA) method using a commercial kit (Imubind-5- tPA, American Diagnostica).4’9 Plasmi[r] ...
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Tissue type plasminogen activator is a neuroprotectant in the mouse hippocampus
... The best-known function of the serine protease tissue-type plasminogen activator (tPA) is as a thrombolytic enzyme. However, it is also found in structures of the brain that are highly ...
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Tissue type plasminogen activator increases the binding of glu plasminogen to clots
... Porcine tissue-type plasminogen activator (t-PA) increases the binding of 125I-glu- plasminogen to clots made from human plasma or purified fibrinogen in a time and t-PA concentration ...
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Localization of the binding site of tissue type plasminogen activator to fibrin
... of tissue-type plasminogen ...two-chain tissue-type plasminogen activator, however, destroyed both the binding and catalytic ...of tissue-type ...
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Fibrinolysis regulation by platelets retaining plasminogen and tissue-type plasminogen activator on their surface
... the plasminogen activation process on the surface of intact platelets and more than two times elevate the level of activation in the presence of thrombin-stimulated ...of plasminogen activation system ...
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Management of Plastic Bronchitis With Topical Tissue-type Plasminogen Activator
... Four months later, the patient pre- sented with respiratory distress, fever, cough, and chest pain. He was admitted to our hospital, where his chest radio- graph again revealed opaci fi cation of the left hemithorax. He ...
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Interaction between plasminogen activator inhibitor type 1 (PAI 1) bound to fibrin and either tissue type plasminogen activator (t PA) or urokinase type plasminogen activator (u PA) Binding of t PA/PAI 1 complexes to fibrin mediated by both the finger and the kringle 2 domain of t PA
... complexes of u-PA and PAI-1 dissociate from the fibrin matrix and are encountered in the fluid phase. In contrast, t-PA/PAI-1 complexes remain bound to fibrin. By employing recombinant t-PA deletion-mutant proteins, that ...
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Extracellular proteolysis in the adult murine brain
... the plasminogen activator/plasmin system in the adult murine central nervous ...system. Tissue-type plasminogen activator is synthesized by neurons of most brain regions, while ...
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Detection and partial characterization of an inhibitor of plasminogen activator in human platelets
... conclusion is supported by a number of observations. For example, extracts of washed, gel- filtered human platelets contain an inhibitor of similar activity and size, and physiological concentrations of thrombin induce ...
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Association of plasminogen activator inhibitor-1 and tissue plasminogen activator with type 2 diabetes and metabolic syndrome in Malaysian subjects
... Plasminogen activator inhibitor-1 (PAI-1) is the pri- mary physiological inhibitor of endogenous fibrinolysis that acts via inhibition of the tissue plasminogen activa- tor (tPA) and the ...
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Inhibition of angiogenesis by platelets in systemic sclerosis patients
... endothelin-1, tissue type plas- minogen activator, plasminogen activator inhibitor type 1, and platelet-derived growth factor in patients with Raynaud’s phenomenon associated ...
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High levels of tissue plasminogen activator (tPA) antigen precede the development of type 2 diabetes in a longitudinal population study. The Northern Sweden MONICA Study
... of type 2 ...of tissue plasminogen activator (tPA) or high activity of its inhibitor (PAI-1), as independent risk factors for CVD is unclear, as these variables seem to mirror most compo- ...
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Regulation of murine type 1 plasminogen activator inhibitor gene expression in vivo Tissue specificity and induction by lipopolysaccharide, tumor necrosis factor alpha, and transforming growth factor beta
... of type 1 plasminogen activator inhibitor (PAI-1) gene expression was studied in vivo employing a murine model ...adipose tissue, heart, and lungs of untreated CB6 (BalbC X C57B16) ...adipose ...
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